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#complextraits

PLOS BiologyPLOSBiology@fediscience.org
2025-10-23

Genetic architectures of #ComplexTraits vary widely. @yuvalsim @jkpritch &co show these diffs arise from mutational target size & heritability per site; when controlled for, all tested traits have similar architectures
@PLOSBiology plos.io/47mZXqT

Heritability and target size underlie differences between trait architectures: examples for three traits. Top: Height (blue) and platelet crit (red) have the same heritability per site h2/L, but height has a much higher mutational target size L. This results in many more hits for height (1533) than for platelet crit (648) (2 left panels). However, the marginal distributions of effect sizes, MAFs, and z-scores of hits are nearly identical for the two traits (3 right panels). Middle: Height (blue) and FEV1 (gold) differ in h2/L, but have similar L. Consequently, the joint distribution of z-scores and MAFs of their hits are markedly different (2 left panels), as are the marginal distributions of hit effect sizes, MAFs and z-scores (right). Bottom: After scaling by their respective , and imposing the more stringent scaled significance threshold (corresponding to FEV1) for both traits, the joint distribution of z-scores and MAFs of their hits (2 left panels) and the corresponding marginal distributions (3 right panels) are highly similar.
Ana ViñuelaAnaVinuela@mas.to
2025-01-06

Casey Brown was a great scientist and an amazing person. He could always make time to catch up with junior people, give encouragement or just joke about pretty much everything.

Now in his honour some of the leading scientist in #genomics and #complextraits have joint to record the Casey Brown #lectures.

From the basics of human #genetics, to #transcriptomics #epigenetics or #machinelearning for genomics. All free to watch.

m.youtube.com/playlist?list=PL

PLOS BiologyPLOSBiology@fediscience.org
2024-09-27

Could changes in levels of circulating #lipid species be predictive of disease? @TabRubina @samrip &co reveal that #PolygenicScores for a range of #ComplexTraits are associated with changes in concentration of circulating lipid species #PLOSBiology plos.io/4eE76E9

Fred Guillaumefredguillaume@ecoevo.social
2022-12-19

#introduction
hei,
finally found my way :)
great to see the #evolution and #ecology community here!
hope to share some of our research taking place at the #UniversityOfHelsinki on #EcoEvolutionaryModelling, #ExperimentalEvolution, #genetics of #adaptation, and #ComputerModelling in #EvolutionaryBiology, with a focus on genetics of #ComplexTraits, #QuantitativeGenetics, and #PopulationGenetics, not forgetting #EcoEvolutionaryDynamics.

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