My technical wish for 2025 is that experiments done over the years in slow-growing gene #deletion strains will be repeated under rapid depletion of the corresponding proteins (#degron).
Especially in the field of #mRNA degradation, it is an illusion that the results obtained in cells growing at different rates are not strongly influenced by the different metabolic levels of the studied cells.
1 Postdoc, 1 Postdoc/Lab manager & 2 PhD students in Immuno-epigenetics
IMol PAS
See the full job description on jobRxiv: https://jobrxiv.org/job/imol-pas-27778-1-postdoc-1-postdoc-lab-manager-2-phd-students-in-immuno-epigenetics/?feed_id=55238
#ScienceJobs #hiring #research #epigenetics #epigenomics #immunology #crispr #degron
Warsaw #Poland #Bioinformatician #Man...
https://jobrxiv.org/job/imol-pas-27778-1-postdoc-1-postdoc-lab-manager-2-phd-students-in-immuno-epigenetics/?feed_id=55238
EMBO Journal Issue 4/23:
- Commentary on #creativity needs in research
- #Degron recognition in orphan complex subunits by CLR4-DCAF12 E3 #ubiquitin #ligase
- #Plasmamembrane topography of #IgM #Bcell receptors
- #YAP roles and regulation in #tumorigenesis
- #Brassinosteroid interplay with #katanin #microtubule severing
Cover by Satarupa Bhaduri, Analine Aguayo, Sonya Neal et al
https://www.embopress.org/toc/14602075/2023/42/4
Protein complex assembly #qualitycontrol in action:
#cryoEM structures by Nico Thomä at FMI and colleagues show how #CRL4-#DCAF12 #ubiquitin E3 #ligase engages a C-terminal di-Glu #degron in CCT5 recognizable only when this subunit is not incorporated into the #TRiC/#CCT #chaperone complex
https://www.embopress.org/doi/10.15252/embj.2022112253
