Our recent Perspective on extrachromosomal circular DNA is the focus of December's GBE Highlight.

Highlight: Running Circles Around Genome Architecture
🔗 https:/doi.org/10.1093/gbe/evaf232

This is our first Highlight produced under the SMBE Fellows Program, written by Shady A. Kuster.

#genome #evolution #eccDNA

From 2022:

Extrachromosomal circular DNA: A neglected nucleic acid molecule in plants.

#ExtrachromosomalCircularDNA #eccDNA #Transposons #PlantScience

https://www.sciencedirect.com/science/article/pii/S1369526622000929

A comprehensive atlas of full-length Arabidopsis eccDNA populations identifies their genomic origins and epigenetic regulation.

#ExtrachromosomalCircularDNA #eccDNA #Transposons #Arabidopsis #MethylationMutants #LongReadSequencing

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003275

Previous studies of extrachromosomal circular DNA #eccDNA in #plants are based on short-read seq. @vanderschuren-lab.bsky.social uses long-read seq to obtain a map of full-length eccDNAs from #Arabidopsis, identifying their genomic origins & epigenetic regulation @PLOSBiology plos.io/44Mq3RI

#DNA element with a murky past is borrowing cell's #repair machinery.

#retrotransposon #parasite #alt_EJ #eccDNA

https://phys.org/news/2023-07-dna-element-murky-cell-machinery.html