Microbe Defies Key Rule in Genetic Code, Offering New Insights into Protein Production
π° Original title: Scientists discover microbe that breaks a fundamental rule of the genetic code
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![[ImageSource: Santiago-Rivera et al. 2025, Angewandte Chemie]
Regular vs gene-edited spider silk with a fluorescent gene added.
In the research paper in Angewandte Chemie the methods and results are detailed, with the knock-out approach of the sine oculis [C1] gene being tried first as a proof of concept. The CRISPR solution was injected into the ovaries of female spiders, whose offspring then carried the mutation. With clear deficiencies in eye development observable in this offspring, the researchers moved on to adding the red fluorescent protein gene with another CRISPR solution, which targets the major ampullate gland where the silk is produced.
<https://onlinelibrary.wiley.com/doi/10.1002/anie.202502068>](https://files.mastodon.social/cache/media_attachments/files/114/982/043/555/954/249/small/813a0c1c5b41b320.jpeg)


