Lmst

Estudo identifica moléculas “desreguladas” na diabetes e no câncer de mama
- cijnusp
https://jornal.usp.br/ciencias/estudo-identifica-moleculas-desreguladas-no-diabetes-e-no-cancer-de-mama/
#Cincias #CinciasdaSade #Biologiamolecular #Cncerdemama #Diabetestipo2 #Expressognica #MicroRNAs #Pesquisaembioqumica

#MicroRNAs play a crucial role in #plant communication within the #rhizosphere, shaping #growth, #development, and resilience to biotic and abiotic stresses. Learn more in a new #JIPB paper by Fahad et al.!
https://doi.org/10.1111/jipb.13860
@wileyplantsci
#PlantSci #roots #botany #OpenAccess 🔓

Diagram illustrating the role of miRNAs in the rhizosphere. Whole plants are shown growing in situ with annotations to indicate the role of miRNAs in pathogen resistance, nodule formation and abiotic stressors.

Researchers hit the target: they transport #microRNAs against #MuscularDystrophy to muscle stem cells using nanoparticles.

🎯 Treated mice showed improved muscle strength.

+info: https://nanociencia.imdea.org/home-en/news/item/researchers-hit-the-target-they-transport-micrornas-against-muscular-dystrophy-to-muscle-stem-cells-using-nanoparticles #IMDEAnanoPublications

Unraveling the #molecular basis of non-host resistance is crucial to improve #crop resilience.
In a new study, Mei et al. report that #rice-specific #microRNAs attack #Sclerotinia via cross-kingdom RNAi. https://doi.org/10.1111/jipb.13840
@wileyplantsci
#PlantSci #CropSci #rapeseed #botany

Diagram to illustrate that--when challenged by the fungal pathogen Sclerotinia sclerotiorum--rice secretes microRNAs like Os-miR169y which targets and suppresses the pathogen ribosomal protein gene SsRPL19, impairing protein synthesis in the pathogen and suppressing pathogen growth and pathogenicity.

Exploring #cadmium-induced alterations in the #expression profile of #microRNAs.

https://phys.org/news/2024-07-exploring-cadmium-profile-micrornas.html

Deregulation of miR‐1245b‐5p and miR‐92a‐3p and their potential target gene, GATA3, in epithelial–mesenchymal transition pathway in breast cancer. https://doi.org/10.1002/cnr2.1955 #BreastCancer #Epithelial‐MesenchymalTransition #Gata3 #Micrornas

#microRNAs slow translating #ribosomes to prevent protein #misfolding in eukaryotes
Hiroaki Sako, Tadashi Yamamoto and colleagues
The unusual presence of #miRNAs targeting protein-coding sequences is shown to influence ribosome speed, thereby allowing time for accurate #polypeptide folding during protein translation.
https://www.embopress.org/doi/full/10.15252/embj.2022112469

Small but mighty!

miRNA cluster miR-17-92 knock out results in complete testis to ovary #SexReversal.

#preLightsAmbassador Martin Estermann highlights work from Alicia Hurtado and team in which a novel role for #microRNAs is uncovered. #preprint

https://prelights.biologists.com/highlights/complete-male-to-female-sex-reversal-in-xy-mice-lacking-the-mir-17%e2%88%bc92-cluster/

Immunofluorescence for SRY (A, red) and SOX9 (B, green) in control or miR-17-92 KO XY differentiating gonads, from E11.0 to E12.5.

A fast and efficient method for #detecting #microRNAs.

#RCA #CRISPR

https://phys.org/news/2023-04-fast-efficient-method-micrornas.html

In a new large-scale #genetic analysis, #scientists have found a set of small #RNA molecules, called #microRNAs, in human #pancreatic cells that are strongly associated with type 2 #diabetes.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/02/bio02092306.html

The connection between #DarkMatter and #microRNA is very fascinating. It definitely shows just how amazing #octopuses are!

New research suggests that #microRNAs play a crucial role in the advanced development of the brain, including in humans. #Octopuses have fascinated scientists and the public with their remarkable #intelligence, from using tools to engaging in creative play, problem-solving, and even escaping from aqua

https://scitechdaily.com/new-research-could-link-evolution-of-complex-life-to-genetic-dark-matter/