#microenvironment

Matt Willemsenmattotcha
2024-08-24
2024-01-28

@cyrilpedia Thank you for sharing! David's work is beautiful and another important piece in the big puzzle of #NKcells in #cancer ...with the other big question: how does the #tumor keep NK cells out of it's #microenvironment ...? @gpollara @chfloudas

2023-11-19

@cyrilpedia Also bringing up the problems with organ-specific microenvironments that have the power to be highly immunosuppressive: liver and brain. #Immunotherapy #organs #microenvironment

2023-11-05

New #mechanobiology paper on #cancer #microenvironment. The authors show that cancer-associated #fibroblasts (CAFs) compress tumors with actomyosin supracellular contractility supported by #fibronectin deposition. This induces #YAP nuclear exit in cancer cells, limits cancer growth, and induces tumor reorganization.

nature.com/articles/s41467-023

David Basanta Gutierrezdavid@fediscience.org
2023-11-01

Excellent seminar at #Moffitt by Prof. Johanna Joyce from The University of Lausanne talking about the importance of the #tumor #microenvironment in cancer

Title slide plus photo of Prof. JoyceSlide about the tumor microenvironment in metastasis
Arjan Boltjestinyspheresof
2023-07-20

Come and work with us - job opening at the Molenaar research group in the Princess Máxima Center for pediatric oncology, looking for a / .

Together with my colleagues and me you will research , with a focus on and the compartment using a range of data and other high-throughput data.


For further information, see the vacancy below:
werkenbijprinsesmaximacentrum.

Arjan Boltjestinyspheresof
2023-05-15

An impressive keynote lecture by Chris Marine on and the role of the , and MES-like cells in and .

Gonzalogcordova
2023-05-01

Just Published!

Pleural Mesothelioma: The Importance of Working Together

link.springer.com/chapter/10.1

2023-03-30

14° outdoors but in the sun the wild marjoram is as warm as dog fur.

The rock is not accidental. Mostly, flies use it to perch. To us it is small but to them it is huge.

Its surfaces are variously dryer, wetter, colder and hotter than its surroundings. On top of that, the heat it captures from the sun warms the immediate area, well into the night.

For plants and insects those marginal differences may be just what they need to thrive.

#gardeningclub #microenvironment #ecology #wildlife

Herbs, grass and a small boulder
2023-03-16

#macrophages are an integral part of the solid tumor #microenvironment and have complex roles in #Immunology , #inflammation and #tissue homeostasis. Here is an elegant review on the topic of #innateimmunity in #cancer
cell.com/cell/fulltext/S0092-8

2023-03-15

Highlighted in issue 6: #Phytosulfokine balancing growth and defense in #plants

Reviews on HIF regulation of #metabolic crosstalk in tumor #microenvironment, and #evolutionary origins of #auxin responses

Further:
Phase separation of #Hippo signalling complexes
#Mitochondrial oxidative stress checkpoint via DNA-PKcs and ATM

Cover by @tatsuofukagawa1 and colleagues

embopress.org/toc/14602075/202

This cover highlights the article The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2 by Honghui Jiang, Mariko Ariyoshi, Tatsuo Fukugawa and colleagues. The CENP‐A nucleosome is the fundamental architecture of the centromere responsible for chromosome segregation. KNL2 is one of key factors for new CENP‐A deposition into the centromeres. Here, using cryo‐EM, biochemical and cell biology experiments, we show that chicken KNL2, instead of CENP‐C, binds to the CENP‐A (green) nucleosome via the conserved CENP‐C like motif (orange) in interphase to maintain the CENP‐A nucleosome in centromeres. In mitosis, phosphorylated CENP‐C dominantly binds to the CENP‐A nucleosome. Our findings provide a new insight into dynamic regulation of structural change of the centromere during the cell cycle progression.(Scientific image by the authors)
David Basanta Gutierrezdavid@fediscience.org
2023-02-22

Join us tomorrow Thursday 2/23 (noon EST). Adam MacLean
from USC
describes his #mathonco work on #cancer in the tumor #microenvironment

t.co/EQXPaGheoo

2023-01-27

🧬MCBG Seminar🧬
Thursday, February 2, 10 AM

Dr. Neta Erez
Professor and Chair
Department of Pathology, Tel Aviv University

Student host: Emily Esquea @drexelmcbg

Stromal and immune plasticity shape the metastatic microenvironment

#cancerbiology #graduateschool #molecularbiology #cellbiology #cancer #microenvironment

Leica Microsystemsleicamicrosystems
2023-01-18

Imaging is a powerful tool in cancer research. Join our latest masterclass and discover the latest imaging techniques, get expert tips, and see how leading researchers are using them to drive new insights into cancer.
☑️ Register now!
bitesizebio.com/cancer-imaging

Gonzalogcordova
2022-12-30

Recently Published!

More than the Genes: The Tumor Microenvironment in Adrenal Gland Carcinoma

link.springer.com/chapter/10.1

Gonzalogcordova
2022-12-29
Gonzalogcordova
2022-12-29

Recently Published!

The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy

link.springer.com/chapter/10.1

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