#TissueEngineering

Geekoogeekoo
2025-03-19

Cells battle for survival by exerting force! A groundbreaking study reveals why mechanical strength—not size—determines which cells live or die.

geekoo.news/cell-showdowns-how

2024-09-01

🔬🦴🩻🧪 Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow 🔍

doi.org/10.1016/j.biomaterials

#biomaterials #tissueengineering #regenerativemedicine #biology #implants #inflammation #immunomodulation #fibrosis #medicine #healthcare #engineering #magnesium #science

Orthopedic implants made of biodegradable magnesium (Mg) provide an alternative to nondegradable implants for fracture repair. Widely reported to be pro-osteogenic, Mg implants are also believed to be anti-inflammatory and anti-osteoclastic, but this is difficult to reconcile with the early clinical inflammation observed around these implants. Here, by surveying implant healing in a rat bone model, we determined the cellular responses and structural assembly of bone correlated with the surface changes of Mg implants inherent in degradation. We show that, compared to titanium, both high-purity (99.998%) and clinical-grade, rare earth-alloyed (MgYREZr) Mg implants create an initial, transient proinflammatory environment that facilitates inducible nitric oxide synthase-mediated macrophage polarization, osteoclastogenesis, and neoangiogenesis programs. While this immunomodulation subsequently reinforces reparative osteogenesis at the surface of both Mg implants, the faster degradation of high-purity Mg implants, but not MgYREZr implants, elicits a compositional alteration in the interfacial bone and a previously unknown proadipogenic response with persistent low-grade inflammation in the surrounding bone marrow. Beyond the need for rigorous tailoring of Mg implants, these data highlight the need to closely monitor osseointegration not only at the immediate implant surface but also in the peri-implant bone and adjacent bone marrow.
2024-08-30

🔬🦴🧪 Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues" 🔎

doi.org/10.1016/j.bioactmat.20

#biomaterials #tissueengineering #regenerativemedicine #biology #implants #inflammation #immunomodulation #fibrosis #medicine #healthcare #engineering #magnesium #science

Implants made of magnesium (Mg) are increasingly employed in patients to achieve osteosynthesis while degrading in situ. Since Mg implants and Mg2+ have been suggested to possess anti-inflammatory properties, the clinically observed soft tissue inflammation around Mg implants is enigmatic. Here, using a rat soft tissue model and a 1–28 d observation period, we determined the temporo-spatial cell distribution and behavior in relation to sequential changes of pure Mg implant surface properties and Mg2+ release. Compared to nondegradable titanium (Ti) implants, Mg degradation exacerbated initial inflammation. Release of Mg degradation products at the tissue-implant interface, culminating at 3 d, actively initiated chemotaxis and upregulated mRNA and protein immunomodulatory markers, particularly inducible nitric oxide synthase and toll-like receptor-4 up to 6 d, yet without a cytotoxic effect. Increased vascularization was demonstrated morphologically, preceded by high expression of vascular endothelial growth factor. The transition to appropriate tissue repair coincided with implant surface enrichment of Ca and P and reduced peri-implant Mg2+ concentration. Mg implants revealed a thinner fibrous encapsulation compared with Ti. The detailed understanding of the relationship between Mg material properties and the spatial and time-resolved cellular processes provides a basis for the interpretation of clinical observations and future tailoring of Mg implants.
2024-08-08

📢 Submission is still possible until 📅 August 31, 2024:
Thematic issue “#Nanomaterials for #BiomedicalApplications” edited by Muhammad Anwaar Nazeer, Seda Kizilel and Filippo Pierini in the #BJNANO 💎🔓:
➡️ beilstein-journals.org/bjnano/
#DrugDelivery #GeneDelivery #Biosensing #Nanofibers #TissueEngineering
#DiamondOpenAccess 💎🔓

Bose-Einstein-KondensatMWNautilus@mstdn.social
2024-07-26
2024-02-07

3D Bioprinting Assembles Functional Human Brain Tissue for The First Time  
Scientists have developed a 3D bioprinting platform that assembles functional human neural tissues............
#3Dbioprinting #Bioprinting #brain #neurons #TissueEngineering
Umesh Prasad

scientificeuropean.co.uk/techn

Lab HorizonsLab_Horizons
2024-01-15

Researchers have developed new 4D hydrogels -- 3D materials that have the ability to change shape over time in response to stimuli -- that can morph multiple times in a preprogrammed or on-demand manner in response to external trigger signals.

Dr. Marie McNeelyPhDMarie@qoto.org
2024-01-08

This week's new PBtS podcast episode features Dr. Claire Higgins! She discussed her research on tissue engineering and regenerative medicine, her passion for pottery, memorable trips to Kyoto, exciting recent research successes, and more! peoplebehindthescience.com/dr-

#podcast #podcasts #scicomm #biology #hair #skin #science #STEM #regenerativemedicine #tissueengineering

On the right side of the image, our podcast cover art is displayed. The text reads "People Behind the Science with Dr. Marie McNeely". On the left side, there is a headshot photo of Dr. Claire Higgins. She has long blonde hair, she is wearing a dark green top, and she is standing in front of a tan marbled background. She is looking at the camera and smiling.
2023-09-29

A company with a process to generate new thymus tissue for immune system functions is receiving a $37 million award from the government's health breakthrough agency.

sciencebusiness.technewslit.co

#News #Press #Science #Business #Thymus #ImmuneSystem #TCells #ARPAH #Biotechnology #StemCells #TissueEngineering #MachineLearning #ArtificialIntelligence #Algorithms

Gonzalogcordova
2023-08-24

Just Published!

"Recellularization of Acellular Xeno Kidney Scaffold: An In Vivo Method to Generate Bioartificial Kidney"

link.springer.com/chapter/10.1

University of LimerickUL@mastodon.ie
2023-04-17

5 advances in tissue engineering you need to know about

Tissue engineering has potential to provide personalised healthcare, grow tissues & organs in the lab & reduce organ donor waiting lists, as UL's Dr Aleksandra Serafin explains:
rte.ie/brainstorm/2023/0414/13

#StudyatUL #Healthcare #Engineering #TissueEngineering #Research #HigherEducationResearch #Learning #Education #University

A photograph of a pipette filling glass beakers with a clear liquid in a research lab. The shot is taken from above showing only the tip of the pipette and the beakers below, which are lit with blue and pink lights
2023-04-03

Thanks for the warm welcome @Readily3D looking forward to more advances in the field!
---
RT @Readily3D
We are excited to have Prof. @RicLevato join Readily3D’s scientific advisory board!

Welcome on board, Riccardo! 🥳
linkedin.com/feed/update/urn:l

#tissueengineering #biofabrication #3dprinting
twitter.com/Readily3D/status/1

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