RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
Very much looking forward to the @led3hub.bsky.social@bsky.brid.gy Lecture by Christina Woo (@thewoolab.bsky.social@bsky.brid.gy)! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
#ChemSky #ChemBio #DrugDiscovery #degrader
RE: https://bsky.app/profile/did:plc:jnlt3o3km3ebst2vcigkwdch/post/3mdvh637p5s2c
Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12) #Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
Last paper post of the year!
Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders
Last paper post of the year!
Amazing @natchembio.nature.com@bsky.brid.gy paper by @thewoolab.bsky.social@bsky.brid.gy. PCMT1 installs cyclic imides at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
PCMT1 generates the C-terminal...
Exciting @biorxivpreprint.bsky.social@bsky.brid.gy by the group of Gunda Georg. They developed a tissue-specific PROTAC that recruits the E3 ligase scaffolding protein MAGEA11 that is highly expressed in many cancers and otherwise only in sperm and placenta. www.biorxiv.org/cont...
#TPD #ChemSky #ChemBio
Design of Tissue-Selective PRO...
Exciting bioRxiv preprint by the group of Gunda Georg. They developed a tissue-specific PROTAC that recruits the E3 ligase scaffolding protein MAGEA11 that is highly expressed in many cancers and otherwise only in sperm and placenta. https://www.biorxiv.org/content/10.1101/2025.11.03.686228v1
#TPD #Chemistry #ChemBio
Superannuation funds accused of delaying disability insurance claims
William Johns is deeply frustrated by the way some of Australia’s major superannuation funds are treating their members.…
#NewsBeep #News #Headlines #ASFA #AU #Australia #disbailityclaims #insurance #insuranceclaims #mentalhealthclaims #mentalheath #super #superconsumersaustralia #superfunds #superannuation #totalandpermanentdisability #tpd
https://www.newsbeep.com/310052/
Exciting study by the group of Alexander Adibekian in JACS. They used antibodies modified with reversible, lysine-directed ketoboronates to develop KB-TACs as lysosomal degraders of membrane and extracellular proteins.
https://doi.org/10.1021/jacs.5c16611
#Chemistry #ChemBio #ChemicalProteomics #DrugDiscovery #TPD
Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
https://pubs.acs.org/doi/full/10.1021/jacs.4c18083
#TPD #Chemistry #ChemBio #ChemicalProteomics
Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine. pubs.acs.org/doi/full/10.... #TPD #ChemSky #ChemBio #ChemicalProteomics
Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202308186
#TPD #Chemistry #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes
Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#TPD #ChemSky #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes
advanced.onlinelibrary.wiley.com/doi/10.1002/ad...
Exciting @biorxivpreprint.bsky.social@bsky.brid.gy by the groups of @pjcossar.bsky.social@bsky.brid.gy and @alessiociulli.bsky.social@bsky.brid.gy. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC recruiting VHL. doi.org/10.1101/2025...
#TPD #ChemSky #ChemBio
Induced ubiquitination of the ...
Interesting bioRxiv preprint by the groups of Peter Cossar and Alessio Ciulli. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC (MG-PROTAC) recruiting VHL. https://doi.org/10.1101/2025.11.17.688825
#DrugDiscovery #TPD #Chemistry #ChemBio
Inspiring #Havinga Medal award lecture by Craig @crews at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
https://www.nature.com/articles/s41573-021-00371-6
#Chemistry #ChemBio #TPD
Congratulations, Craig Crews, on being recognized with this award for your truly groundbreaking work.
Inspiring #Havinga Medal lecture by @craigmcrews.bsky.social at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery. www.nature.com/articles/s41... #ChemSky #ChemBio #TPD
Huge congratulations to Craig @crews from Yale on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#Chemistry #ChemBio #TPD
