Preplanned Studies: #Phylogenetic and #Molecular Characteristics of An #H3N8 Avian #Influenza Virus Detected in Wild #Birds — #Beijing, #China, September 2024, https://etidiohnew.blogspot.com/2025/11/preplanned-studies-phylogenetic-and.html

Fatal #Human #H3N8 #Influenza Virus has a Moderate #Pandemic #Risk, https://etidiohnew.blogspot.com/2025/10/fatal-human-h3n8-influenza-virus-has.html

Detection of a Novel #Gull-like Clade of Newcastle Disease Virus and #H3N8 Avian #Influenza Virus in the #Arctic Region of #Russia (Taimyr Peninsula), https://etidiohnew.blogspot.com/2025/07/detection-of-novel-gull-like-clade-of.html

#India - #Equine #influenza #H3N8 virus (Inf. with) - Immediate notification, https://etidiohnew.blogspot.com/2025/07/india-equine-influenza-h3n8-virus-inf.html

Structural basis of #receptor-binding #adaptation of #human-infecting #H3N8 #influenza A virus, https://etidiohnew.blogspot.com/2025/02/structural-basis-of-receptor-binding.html

Prior #infection with IBDV prolonged the shedding of a #mallard #H3N8 #influenza A virus (IAV) challenge from oropharyngeal cavity of some #chickens {...}, https://etidiohnew.blogspot.com/2025/01/prior-infection-with-ibdv-prolonged.html

Use of #equine #H3N8 #hemagglutinin as a broadly protective #influenza #vaccine immunogen, https://etidiohnew.blogspot.com/2024/12/use-of-equine-h3n8-hemagglutinin-as.html

Meta-Analysis of #Seroprevalence and #Prevalence of #Influenza A Viruses (Subtypes #H3N2, #H3N8, and #H1N1) in #Dogs, https://etidiohnew.blogspot.com/2024/12/meta-analysis-of-seroprevalence-and.html

First #detection of #influenza A virus subtypes #H1N1 and #H3N8 in the #Antarctic region: King George Island, 2023

Source: Vopr Virusol., AbstractRelevance. Influenza A virus is characterized by a segmented single-stranded RNA genome. Such organization of the virus genome determines the possibility of reassortment, which can lead to the emergence of new virus variants. The main natural reservoir of most influenza A virus subtypes are wild waterfowl. Seasonal migrations…

https://etidioh.wordpress.com/2024/10/04/first-detection-of-influenza-a-virus-subtypes-h1n1-and-h3n8-in-the-antarctic-region-king-george-island-2023/

An emerging #PB2-627 #polymorphism increases #pandemic #potential of avian #influenza virus by breaking through ANP32 host restriction in #mammalian & avian hosts, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.07.03.601996v4

by screening the global PB2 seq., we discovered a new independent cluster with PB2-627V emerged in the '10s, which is prevalent in various avian, mammalian, & human isolates of AIVs, including #H9N2, #H7N9, #H3N8, 2.3.4.4b #H5N1, and other subtypes.

Use of #equine #H3N8 #HA as a broadly protective #influenza #vaccine #immunogen, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.30.610504v1

Vaccinated ferrets exhibited similar broadly reactive serum #antibody responses that protected vaccinees from clinical signs of infection & viral-induced histopathology after challenge with H1N1pdm09 virus. These data suggest that vaccination with equine H3N8 vaccine induces broad protection vs flu without need for non-influenza viral vectors, ...

#Adaptation potential of #H3N8 canine #influenza virus in #human respiratory #cells, Sci Rep.: https://www.nature.com/articles/s41598-024-69509-x

We found that CIV acquired high growth properties in these cells mainly through #mutations in surface #glycoproteins, such as hemagglutinin (#HA) and neuraminidase (#NA). Our reverse genetics approach revealed that HA2-K82E, HA2-R163K, and NA-S18L mutations were responsible for the increased growth of CIV in human cells.

An emerging #PB2-627 #polymorphism increases the #pandemic #potential of avian #influenza virus by breaking through ANP32 #host #restriction in #mammalian and avian hosts, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.07.03.601996v3

...we discovered a new independent #cluster with PB2-627V emerged in the 2010s, which is prevalent in various avian, mammalian, and human isolates of AIVs, including #H9N2, #H7N9, #H3N8, 2.3.4.4b #H5N1, and other subtypes.

#Zoonotic #infections by avian #influenza virus: changing global #epidemiology, #investigation, and #control, Lancet Infect Dis.: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00234-2/abstract

Avian influenza virus continues to pose zoonotic, #epizootic, and #pandemic #threats worldwide, as exemplified by the 2020–23 epizootics of re-emerging #H5 #genotype avian influenza viruses among #birds and #mammals and the fatal jump to humans of emerging A(#H3N8) in early 2023.

Large-Scale #Serological #Survey of #Influenza A Virus in South #Korean Wild #Boar (Sus scrofa) https://pubmed.ncbi.nlm.nih.gov/38842623/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1fgJURi2yzLesFml6et0Bb6krzs_FrNIYgPYVFN50JPwVNFg9s&fc=None&ff=20240606155644&v=2.18.0.post9+e462414

Detected subtypes included 23 cases of pandemic 2009 #H1N1, six of human seasonal #H3N2, three of classical swine H1N1, 13 of triple-reassortant swine #H1N2, seven of triple-reassortant swine H3N2, and seven of swine-origin H3N2 variant. Notably, none of the serum samples tested positive for avian IAV subtypes #H3N8, #H5N3, #H7N7, and #H9N2 or canine IAV subtype H3N2.

Avian #Influenza Virus and Avian #Paramyxoviruses in Wild #Waterfowl of the Western Coast of the #Caspian Sea (2017–2020), Viruses: https://www.mdpi.com/1999-4915/16/4/598

The following subtypes were determined and whole-genome nucleotide sequences of the isolated strains were obtained: #H1N1 (n = 2), #H3N8 (n = 8), #H4N6 (n = 2), #H7N3 (n = 2), #H8N4 (n = 1), #H10N5 (n = 1), and #H12N5 (n = 1). No high pathogenicity influenza virus H5 subtype was detected.

#Molecular Characterization of Non- #H5 and Non- #H7 Avian #Influenza Viruses from Non-Mallard #Migratory #Waterbirds of the North #American #Flyways, 2006–2011, Pathogens: https://www.mdpi.com/2076-0817/13/4/333

The most common H and N combinations were #H3N8 (23.0%), #H4N6 (18.4%), and #H4N8 (18.4%). The HA gene between non-mallard and mallard MW isolates during the same time period shared 85.5–99.5% H3 identity and 89.3–99.7% H4 identity.

High-pathogenicity avian influenza in wildlife:
a changing disease dynamic that is expanding
in wild birds and having an increasing impact
on a growing number of mammals

#H1N1 #H3N8 #avian_influenza #IAV

https://avmajournals.avma.org/view/journals/javma/aop/javma.24.01.0053/javma.24.01.0053.xml

#Surveillance and #Genetic Analysis of LP Avian #Influenza Viruses Isolated from #Feces of Wild #Birds in #Mongolia, 2021 to 2023, Animals (Basel), https://www.mdpi.com/2076-2615/14/7/1105

Prevalence of AIVs in wildbirds was 1.01%, with a total of 77 AIVs isolated during these 3 years. These 77 AIVs included HA subtypes H1, H2, H3, H4, H6, H10 and H13 and neuraminidase (NA) subtypes N1, N2, N3, N6, N7 and N8. The most frequently detected subtype combinations were #H3N8 (39.0%) and #H4N6 (19.5%)...

Avian #Influenza Virus and Avian #Paramyxoviruses in Wild #Waterfowl of the Western Coast of the #Caspian Sea (2017–2020), Viruses: https://www.mdpi.com/1999-4915/16/4/598

The following subtypes were determined and whole-genome nucleotide sequences of the isolated strains were obtained: #H1N1 (n = 2), #H3N8 (n = 8), #H4N6 (n = 2), #H7N3 (n = 2), #H8N4 (n = 1), #H10N5 (n = 1), and #H12N5 (n = 1). No high pathogenicity influenza virus H5 subtype was detected.