'We discovered that the Neisseria gonorrhoeae transcriptional response to PMNs has features in common with the transcriptional response to nutrient metals and oxidative stress, which enhance Neisseria gonorrhoeae resistance to hydrogen peroxide & polymorphonuclear leukocytes.'
#Immunology #HostPathogen
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012369#sec010
New paper collab with WPI!
"A correlative study of the genomic underpinning of virulence traits and drug tolerance of Candida auris"
https://journals.asm.org/doi/10.1128/iai.00103-24
#bioinformatics #rnaseq #genomics #drugresistance #candida #PathogenGenomics #hostpathogen
This is a really great overview of innate immunity concepts across organisms. A really fantastic conceptual read and one that I may add to my "required reading" list for training new students/lab members in concepts of innate immunity.
https://www.cell.com/immunity/fulltext/S1074-7613(24)00128-6
#Drosophila #Celegans #HostPathogen #Immunology #InnateImmunity
'By employing a metabolic compartmentalization approach, we observed enhanced glycolysis and accumulation of the TCA-cycle derivative itaconate in splenic monocyte-derived dendritic cells from Plasmodium chabaudi (Pc)-infected mice.'
#Malaria #Plasmodium #HostPathogen #Metabolism #immunology
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00008-1
"Notably, infection and transmission of SARS-CoV-2 in mink resulted in adaptive mutations in the virus genome, and viruses with these mink-origin mutations were detected in humans, suggesting mink-to-human transmission of the virus"
#SarsCov2 #Covid19 #Covid #HostPathogen
Live long & prosper. And host pathogens.
"The white-footed deermouse Peromyscus leucopus, a long-lived rodent, is a key reservoir for agents of several zoonoses, including Lyme disease. While persistently infected, this deermouse is without apparent disability or diminished fitness"
#immunology #InfectiousDisease #HostPathogen #ResistanceTolerance
'Hence, a parasite protein known to bind two host cytokine receptor subunits has evolved a third receptor specificity, which serves to raise the avidity and cell type–specific potency of TGF-β signaling in mammalian cells.'
#immunology #Parasitology #HostPathogen
'Together, these results demonstrate that host cGAS–STING senses T. cruzi infection, enhancing parasite growth at the site of entry, and contributes to acute-phase parasite restriction in the heart, a major site of tissue damage in chronic T. cruzi infection.'
#immunology #InnateImmunity #HostPathogen
'Although infection and these translocated effector proteins are restricted to intestinal epithelial cells (IEC), type I dendritic cells (cDC1) were required to generate CD8+ T cell responses to these model antigens.'
'In conclusion, mitochondrial perturbation of the epithelium causes dysbiotic expansion of Bacteroides spp., supporting the concept that microbe-host cross-talk contributes to metabolic injury in intestinal inflammation.'
#Preprint #HostPathogen #metabolism #Immunology #MucosalImmunology
'Therefore, to understand the influence of Wolbachia on within-host ZIKV evolution, we characterized the genetic diversity of molecularly barcoded ZIKV virus populations replicating in Wolbachia-infected mosquitoes and found that within-host ZIKV evolution was subject to weak purifying selection and, unexpectedly, loose anatomical bottlenecks in the presence and absence of Wolbachia'
#Preprint #Wolbachia #HostPathogen #Virology #InnateImmunity
'To study regulators of bacterial pathogenicity that are the major drivers of infectious disease outcome, we developed scPAIR-seq, an approach to functionally analyze the effects of bacterial mutants on host immunity at single-cell resolution.'
"In this study, we provide a more comprehensive understanding of the relationship among these cellular subsets, uncover a novel homeostatic function in human NK cells, and illuminate how HIV-1 infection disrupts these cellular subsets and their functions"
#HIV #InfectiousDisease #HostPathogen #Immunology #virology
Wang et al @embojournal
'Tuberculosis (TB) is a heterogenous disease in humans with individuals exhibiting a wide range of susceptibility. This heterogeneity is not captured by standard laboratory mouse lines. We used a new collection of 19 wild-derived inbred mouse lines collected from diverse geographic sites to identify novel phenotypes during Mycobacterium tuberculosis (Mtb) infection.'
#Preprint #Tuberculosis #Immunology #HostPathogen #InfectiousDisease
Progress on understanding #endometriosis
"In a cohort of women, 64% of patients with endometriosis but <10% of controls were found to have Fusobacterium infiltration in the endometrium. Immunohistochemical and biochemical analyses revealed that activated transforming growth factor–β (TGF-β) signaling resulting from Fusobacterium infection of endometrial cells led to the transition from quiescent fibroblasts to transgelin (TAGLN)–positive myofibroblasts, which gained the ability to proliferate, adhere, and migrate in vitro."
#HostPathogen
'Here, we aimed to understand how closely related strains with overlapping metabolic capacities can co-bloom (i.e., both strains reaching high densities) in the mammalian gut and how this promotes the spread of antibiotic resistance plasmids.'
#HostPathogen #microbiology #mucosalimmunology
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00222-6
'Anomotaenia brevis, a cestode that uses Temnothorax nylanderi ants as intermediate hosts, extends the lifespan of these hosts several fold and changes their behaviour, morphology, and colouration. The mechanisms behind these changes are unknown, as is whether the increased longevity is achieved through manipulation of the parasite.'
'Flagella-driven motility is essential for the entry of H. pylori into the mucus layer and for maintaining a swimming reservoir in the mucus (Fig. 3). H. pylori has a unipolar bundle of rotating sheathed flagella, with filaments composed of two flagellin proteins that evade activating the innate immune system via TLR5 due to specific adaptation of their amino acid sequences'
'Studies herein with Salmonella demonstrate that the interactions of structurally related, but functionally unique, α-helical Gre factors with the secondary channel of RNA polymerase elicit the expression of metabolic signatures that are associated with resistance to oxidative killing.'
#Microbiology #HostPathogen
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002051
'Using fluorescence microscopy, we show that B. burgdorferi associates with mouse and human cells in culture, and we document that internalized spirochetes colocalize with the pattern recognition receptor cyclic GMP-AMP synthase (cGAS).'
