What could be more exciting right now than listening to Dario Alessi share stories about his work unraveling the mysteries of how the LRRK2 gene contributes to Parkinson's disease? Nothing. Absolutely nothing. (At least in my opinion.)

https://open.spotify.com/episode/2x474VHmqJ7dfakk2fspcd

#neuroscience #scicomm #brain #parkinsonsdisease #parkinsons #genetics #research #science #podcast #podcasts #LRRK2

α⧸ω ST phosphorylation diagrams for human and mouse leucine rich repeat kinase 2 (#LRRK2:p). The AF model for the human sequence shown has the prominent, complex phospho-IDR illustrated as a stringy region at the top of the structure between an ankyrin-like solenoid (left) & a leucine-rich repeat solenoid (right). As usual, the shape & orientation of the phospho-IDR in this model is not to be taken too seriously. #proteomics

Regulation of #LRRK2 mRNA stability by ATIC and its substrate #AICAR through ARE-mediated mRNA decay in #Parkinson's disease
Yulan Xiong and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022113410

‘Game-changing’ technique could identify Parkinson’s before symptoms show | The Independent
#Parkinsons
#ParkinsonsDiagnosis
#AlphaSyn
#AlphaSynSAA
#GBA
#LRRK2
#LossOfSmell
https://www.independent.co.uk/news/health/parkison-s-diagnosis-protein-study-symptoms-b2318504.html

We found that the #Parkinson's disease related kinase #LRRK2 interacts with vesicular #SNAREs #VAMP4 and #VAMP7. #VAMP4 and #VAMP7 are required for proper processing and release of #Parkinson's disease #biomarkers #VGF as we found using #secretomics. We found late endosomal #secretion of #VGF together with #exosome markers like #CD63. We also developed a #rushassay to study #VGF #trafficking.

#Secretion of #VGF relies on the interplay between #LRRK2 and post-Golgi v-SNAREs #VAMP4 #VAMP7.
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00232-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723002322%3Fshowall%3Dtrue

New preprint from my colleagues at Denali: https://www.biorxiv.org/content/10.1101/2022.12.19.521070v1 They describe how the LRRK2 kinase, a risk factor for Parkinson's Disease regulates secretion of BMP, an endolysosomal lipid involved in glycosphingolipid (GSL) catabolism, from kidney into urine and modulates BMP and GSL levels in the brain. #neurodegeneration #lrrk2 #parkinsons #lipids #omics