6-Mar-2025
A new algorithm sheds light on ‘disordered’ #proteins
The #IntrinsicallyDisorderedProteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making #structurePrediction particularly challenging. These proteins although exhibit chaotic and ‘disordered’ structures, they still perform essential functions.
https://www.eurekalert.org/news-releases/1075837 #science
I use Alphafold (actually colabfold) and am happy to answer questions, but I'm just a user. There are people with more expertise than me here.
Hashtags might find the right people
#StructurePrediction #alphafold #alphafold2 #colabfold #ProteinStructure #StructuralBiology #ProteinPrediction #protein #bioinformatics
"The designs for all eight of the predicted novel αβ-folds with a four-stranded β-sheet, including a knot-forming one, folded into #structures close to the design models. Further, the rules predicted more than 10,000 novel αβ-folds with five- to eight-stranded β-sheets; this number far exceeds the number of αβ-folds observed in #nature so far."
https://www.nature.com/articles/s41594-023-01029-0
#protein #folding #proteinFolding #structuralBiology #structurePrediction
Research Topics of interest:
* Protein #structureprediction - #antibodies and TCRs
* #NLP and #languages in general. E.g., there are many Korean expressions that I wish I could say in English and vice-versa, and I wonder if LLMs will ever "know" the frustration! (Meta: thinking about this makes me 답답해)
* Few/zero shot learning, self supervision
* repertoire scale #NGS analyses
