Versoza et al. use WGS of pedigrees of aye-ayes to map crossover and noncrossover recombination events.

🔗 doi.org/10.1093/gbe/evaf072

#genome #primate #recombination #evolution

If you're interested in population genetics and cooperation, you might be interested in our latest theory paper on the topic! Check it out!

⬇️ ⬇️
https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpae147/7821382
⬆️ ⬆️

#evolution #popgen #cooperation #altruism #recombination

“Broadly stated, the imagination has five steps: mimicry; abstraction/decoupling; recombination; expression; and social feedback.“

#imagination #mimicry #abstraction #recombination #expression #feedback

#Recombination across distant #coronavirid #species and #genera is a rare #event with distinct #genomic features

Source: Journal of Virology, ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2; family Coronaviridae, genus Betacoronavirus, subgenus Sarbecovirus) has caused millions of deaths, prompting a need for better understanding of coronavirid emergence and spillover to humans. As an evaluation of how some features of SARS-CoV-2, unique among…

https://etidioh.wordpress.com/2024/11/19/recombination-across-distant-coronavirid-species-and-genera-is-a-rare-event-with-distinct-genomic-features/

#VideoTitle "Top Four Recent Human Evolution Discoveries", by https://youtube.com/@gutsickgibbon at https://youtu.be/ZJLm5ag7bRw

#VideoDescription
"""[…]

[1] Vocal labeling of others by nonhuman primates
https://www.science.org/doi/10.1126/science.adp3757

[2] Early evolution of small body size in Homo floresiensis
https://www.nature.com/articles/s41467-024-50649-7

[3] A 4.3-million-year-old Australopithecus anamensis mandible from Ileret, East Turkana, Kenya, and its paleoenvironmental context
https://www.sciencedirect.com/science/article/abs/pii/S0047248424000873

[4] Long genetic and social isolation in Neanderthals before their extinction
https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00177-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666979X24001770%3Fshowall%3Dtrue

[5] Spatial sampling bias influences our understanding of early hominin evolution in eastern Africa
https://www.nature.com/articles/s41559-024-02522-5

[6] Darwin's fear was unjustified: Study suggests fossil record gaps not a major issue
https://phys.org/news/2024-08-darwin-unjustified-fossil-gaps-major.html

[7] Annelid Comparative Genomics and the Evolution of Massive Lineage-Specific Genome Rearrangement in Bilaterians
https://academic.oup.com/mbe/article/41/9/msae172/7733614?login=false
"""

TAGS:
[1] #Cognition #cognitiveFunction #Vocalization #vocalCall #Marmoset #Language #Communication #socialCommunication

[2] #HomoGenus #H_floresiensis #H_luzonensis #MataMenge #FloresIsland #Indonesia #middlePleistocene #Pleistocene #homininFossil #Java #H_erectus #60ka #700ka

[3] #homininMandible #EastTurkana #Kenya #4_3Ma #Australopithecus #Au_anamensis #Au_afarensis #Ardipithecus #Ar_ramidus #Anagenesis #Cladogenesis

[4] #Neanderthal #Thorin #Eurasia #Gibraltar #GrotteMandrin #France #50ka #42ka #105ka

[5] #EasternAfricanRiftSystem #EARS #cercopithecinePrimate

[6] #FossilRecord #Simulation #Projection #Resolution

[7] #Genome #Genomics #Recombination #geneticRecombination #Adaptation #Speciation #bilateralSymmetry #Annelida #Clitellata #Leech #Earthworm

[Correspondence] #Recombination as an evolutionary #driver of #MERS-related #coronavirus emergence https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00461-4/fulltext?rss=yes

The emergence of MERS-CoV in #camels and humans was preceded by an important recombination event, in which the ancestral #receptor binding domain was replaced with that of a different merbecovirus lineage, thereby altering receptor usage.

🧬 New recombination review 🧬
Genetic variation is essential for evolution. So what do we know about genetic variation underlying recombination rates & distribution? I've written a perspective for MBE on why its important, what we have learned, & open questions for the future.

https://academic.oup.com/mbe/article/41/7/msae112/7705493?login=false

#recombination #meiosis #meiosis4eva

Hi everybody,

I am pleased to share with you my latest work in collaboration with Augustin Cléssin and Nicolas Lartillot:

https://www.biorxiv.org/content/10.1101/2024.06.21.600052v1

GC-biased gene conversion (gBGC) is a process that distorts the segregation of heterozygous AT:GC polymorphisms during meiotic #recombination. This genome-wide non-Mendelian segregation has been shown to be a major source of #genetic load, earning the nickname of “Achille’s heel” of #genomes. (1/2)

#PopGen
#Evolution

New lab preprint: GWAS on crossover dynamics in pigs led by Cathrine Brekke. We explored individual variation in rate, positioning and interference and found a few significant loci in females🐷:

📈👯‍♀️ Rate & interference associated with RNF212 (+ small rate effects at CTCF & REC114/REC8/CCNB1IP1)

📌 Broad-scale positioning at MEI4, SYCP2, PRDM9 (+ small effects at ZCWPW1 & ZCWPW2)

#meiosis #pigs #GWAS #recombination #meiosis4eva

https://biologists.social/@biorxivpreprint/112673500288980099

Researchers study the intricacies of #homologous #recombination and abnormal #chromosome_bridges.

#DNA_repair #RAD51 #FIGNL1

https://phys.org/news/2024-05-intricacies-homologous-recombination-abnormal-chromosome.html

@knittingknots2 the dna fragments and pervasiveness show how widespread it is - yeah stay away from raw milk - it has been going on for 36 mos supposedly and is infecting dolphins - hopefully will not infect armadillos and combine with leprosy to form a potent new supervirus/bacteria #gordian knots #recombination

Exploring the Marvel of Genetic Variation: Nature’s Endless Symphony

#Adaptation, #DNARecombination, #Gene, #GeneFlow, #GeneticVariation, #Mutation, #Recombination #Genetics Genetics, the study of heredity and variation, unveils the intricacies of life's blueprint. At the heart of this intricate dance lies genetic variation, the driving force behind evolution, diversity, and the uniqueness of every living organism.…. Medical Microbiology & Recombinant DNA Technology…

https://micrordt.wordpress.com/2024/04/30/exploring-the-marvel-of-genetic-variation-natures-endless-symphony/

Hello everyone,

I'm glad to share this preprint:

https://www.biorxiv.org/content/10.1101/2024.03.06.583651v1

PRDM9 is a gene that determines the location of most meiotic #recombination events through local histone methylation in humans and mice. It is also one of the fastest evolving gene in mammals.

In this preprint, we show that its molecular function in #meiosis is the same in salmonids!

This suggests that PRDM9's rapid #evolution has been going on for hundreds of Mys.

#PopGen

`HCR3 encodes J3, a co-chaperone..which acts to target protein aggregates & biomolecular #condensates to the disassembly chaperone HSP70..promoting proteasomal degradation..a network of HCR3 & HSP70 chaperones facilitates #proteolysis of HEI10, thereby regulating interference & the #recombination landscape. These results reveal a new role for the HSP40/J3-HSP70 chaperones in regulating #chromosome-wide dynamics of recombination via control of HEI10 proteolysis`

https://www.nature.com/articles/s41477-024-01633-y

#meiosis

What are the dynamics of #recombination in natural bacterial populations? Zhiru Liu & @benjaminhgood use #metagenomics to quantify the recombination landscape in ~30 common species of human #GutBacteria, revealing widespread variation within and across species #PLOSBiology https://plos.io/3wbs5NP

Now available ahead of print! "A Numerical Model Supports the Evolutionary Advantage of Recombination Plasticity in Shifting Environments" by Rybnikov et al. https://www.journals.uchicago.edu/doi/10.1086/728405

#evolution #advantage #recombination #plasticity #numericalModel

Hello Mastodon people,

I wanted to mention that I have a new preprint out on bioRxiv:

https://www.biorxiv.org/content/10.1101/2024.01.16.575829v1

I think it could be really useful for people interested in the consequences of #Recombination on #Genome #Evolution, but more generally in interpreting DFEs, positive selection and dN/dS.

I will take the time to make a thread once the final paper is published (I hope it will).

For those who will take the time to read it, don't hesitate to give me feedback 😊

#Popgen

-- we identify three #recombination hotspots of #Delta – #Omicron BA.1 intra-host recombinants.

Systematic #detection of #coinfection and intra-host #recombination in more than 2 million #global #SARS-CoV-2 samples https://www.nature.com/articles/s41467-023-43391-z

In many euraryotes, #recombination events are not evenly distributed across the genome and tend to be concentrated in so-called recombination hotspots. In humans and mice, nearly all recombination hotspots are determined by the protein PRDM9. In species lacking PRDM9, recombiation tends to occur in promoter-like features such as CpG islands (default hotspots). In this study, we have shown that these default hotspots are also active in the presence of PRDM9 in many placental mammals. (2/8)