"APOE3ch binding to heparin sulfate proteoglycans. APOE3ch influences the #microglial response to Aβ plaques, which suppresses Aβ-induced tau seeding and spreading. The results reveal new possibilities to target Aβ-induced tauopathy."
#microglial
Learn more about the intriguing mouse strain-specific #microglial phenotype in #aging and join Marie Pietrowski 💪 at her poster T05-064C at the #gliameeting in #Berlin today 😊
@dzne #GLIA2023
Clearing Toxic Waste Linked to Alzheimer’s – Study Finds Game-Changing Way To Boost Brain Immune Cells
A recent discovery of an “energy switch” within immune cells in the brain holds promise for the creation of drugs to treat Alzheimer’s disease, which is the most widespread form of dementia.
by blocking and deactivating the aforementioned “switch”, microglial immune cells in the brain were able to remove toxic proteins that can build up and lead to Alzheimer’s disease.
https://scitechdaily.com/clearing-toxic-waste-linked-to-alzheimers-study-finds-game-changing-way-to-boost-brain-immune-cells/ #toxic #waste #alzheimers #BrainCells #microglial
Happy New Year 2023!
Our first issue brings:
#Calreticulin conformation changes in cold response
Mammalian #CDC14 #phosphatase controls #stemness exit in #pluripotent cells
#Exosomal #interleukin release via #IQGAP1-mediated #gasdermin-#ESCRT bridging
#Microglial TNFα and cortical protein #phosphorylation during #sleep
...and more:
https://www.embopress.org/toc/14602075/2023/42/1
They are big eaters that kill #viruses, #damaged #cells and #infectious agents they come across. It has long been known that #microglial cells can be activated in different ways in several #neurological #diseases such as #Alzheimer's and #Parkinson's diseases.
#Neuroscience #sflorg
https://www.sflorg.com/2022/11/ns11292201.html
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