Effect of Severe Acute Respiratory Syndrome Coronavirus 2 (#SARSCoV2) Reinfection on Long-Term Symptoms in the Innovative Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE)
> The timing of initial infection, reinfection, and the variants involved may play important roles in longer-term clinical outcomes. Repeated infection with Omicron variants may increase the risk of long-term symptoms.
> For individuals who experienced their first infections in either the pre-Delta or #Delta periods, the odds of having ≥3 symptoms 3–6 months after their most recent infection was lower in those reinfected than those with a single infection (weighted adjusted odds ratio, 0.45 [95% confidence interval, .21–.95] and 0.51 [.32–.79], respectively). However, in individuals reporting their first infection during the #Omicron wave, the odds of reporting ≥3 symptoms after the most recent infection was higher in those reinfected than in those with a single infection (weighted adjusted odds ratio, 1.54 [95% confidence interval, 1.02–2.34]).
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf225/8166544
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