#Reprogramming

Kirill Bereznevktoznet
2025-06-05

I Don’t React. I Reprogram.
Reaction burns energy. Reprogramming builds it.

I track where I leak. Where I collapse. I don’t blame — I design better. My nervous system is my architecture.


bereznev.gumroad.com/l/insider
P.S. Made by a madman — Kirill Bereznev

bereznev.gumroad.com/l/insider

Giuseppe MichieliGMIK69@mstdn.science
2025-04-25
2025-03-28

4.) Is there currently any evidence of efficacy of any of the proposed "#anti-aging drugs" and interventions in human aging? E.g. #rapamycin, #metformin #resveratrol but also #reprogramming, #rejuvenation, #caloric restriction and others? In other words, is there a shortcut to health and eternal life? Spoiler: you might not like the answer... Moreover, some of these might even have negative effects on other health-beneficial interventions, e.g. the potential dampening of exercise training adaptation by metformin, resveratrol or rapamycin.

5.) We discuss all of the known factors for which solid data and proof for an impact on human health, the aging process, #morbidity (risk for a disease), #mortality (risk of premature death) and life expectancy exist. The good news: only around 20% (or even as low as 10%) of our aging trajectory is determined by our genes – this means that to a large majority, we can influence this ourselves! Some can be done on the individual level, first and foremost by physical activity, but also #sleep, #nutrition, #stress, social interactions and more. Others will have to be addressed on the societal/political level, e.g. #socioeconomic disparities or access to quality (and affordable) health care. Lastly, there are factors such as anthropogenic #climatechange or #pollution (e.g. air pollution or #microplastics) that we have to solve on a global scale.

2/4

2024-11-06

Ascl1 modified at 6 sites to be phosphorylation-resistant leads to in vivo reprogramming of Astrocytes into PV+ fast-spiking neurons. (Also this is enhanced by co-expressing Bcl2).

Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site–deficient Ascl1
Marichal et al., Science Advances 2024
doi.org/10.1126/sciadv.adl5935

#neuroscience #interneurons #reprogramming

Fig. 4. Induced neurons generated by coexpression of Ascl1SA6 and Bcl2 acquired functional properties of fast-spiking interneurons.
(A) Example of recorded Ascl1/Bcl2 cotransduced cell visualized in an acute brain slice. Insets show DsRed expression depicting the morphology of the cell (top inset) and colocalization of DsRed and GFP in the soma (bottom insets). (B) Ascl1/Bcl2 cell showing a single small spike in response to depolarizing current injection (12 of 13 recorded cells, n = 5 mice). The single spike was sensitive to tetrodotoxin (TTX) (three of three cells), indicating that it was mediated by voltage-gated Na+ channels. (C) Recorded Ascl1SA6/Bcl2 cotransduced cell visualized in an acute brain slice. Insets similar as in (A). (D) Ascl1SA6/Bcl2 iN showing repetitive action potential with an instantaneous firing frequency (IFF) in the range of 50 Hz in response to depolarizing current injection (6 of 14 recorded cells, n = 8 mice). (E) Ascl1SA6/Bcl2 iN showing sustained high IFF (>100 Hz, 8 of 14 recorded cells, n = 8 mice). (F) Maximum firing frequency values in recorded Ascl1/Bcl2 and Ascl1SA6/Bcl2 iNs. Each dot represents one cell. Data are shown with box and whisker plots, which give the mean (+), median, 25th and 75th percentiles, and range. (G) iNs expressing mRNA of the voltage-gated K+ channel Kv3.1 (Kcnc1).
Simon Tesla 🏳️‍🌈🐭SimonTesla@chitter.xyz
2024-06-11
Simon Tesla 🏳️‍🌈🐭SimonTesla@chitter.xyz
2024-05-11
HARD–WARE–HUNTER | AUIDO-VIDEOhw_hunter92@mastodon.ml
2024-05-10

Никто не ждал, никто не просил, никто не хотел...
Но я всё равно вернулся с новым видиком про железо. Да и не просто с железом, а с самодостаточным девайсом времен Pentium 4.
478 сокет не только вечен, он ещё и вездесущ.

youtu.be/K7S_8W5iDCA?si=A9L-Ws

#pentium4 #retrocomputing #reprogramming #hwh

Simon Tesla 🏳️‍🌈🐭SimonTesla@chitter.xyz
2024-02-25
2023-12-20

#RegenerativeMedicine
Scientists @HelmholtzMunich discovered the role of #RNA polymerase in shaping the replication timing (RT) in embryonic cells & its impact on #cell #plasticity & cell identity.
Paving ways for therapies by #reprogramming.
nachrichten.idw-online.de/2023

Foto darf nur im Zusammenhang mit der Pressemitteilung verwendet werden.
2023-12-20

#RegenerativeMedicine
Scientists @HelmholtzMunich discovered the role of #RNA polymerase in shaping the replication timing (RT) in embryonic cells & its impact on #cell #plasticity & cell identity.
Paving ways for therapies by #reprogramming.
nachrichten.idw-online.de/2023

Foto darf nur im Zusammenhang mit der Pressemitteilung verwendet werden.
2023-12-06

Does #circadian gene expression affect #reprogramming of differentiated cells? Study shows that contaminating #macrophages in #fibroblast culture can inhibit reprogramming to #neurons & #iPSCs, controlled by the clock gene Per1 #PLOSBiology plos.io/47YBh6d

Aksiomaaksioma
2023-11-24

The last guest in series is . He is a founder of Forensic Architecture, where he helped develop a methodology – counter forensics – for 𝗮𝗻𝗮𝗹𝘆𝘀𝗶𝗻𝗴 𝗰𝗮𝘀𝗲𝘀 𝗼𝗳 𝗵𝘂𝗺𝗮𝗻 𝗿𝗶𝗴𝗵𝘁𝘀 𝘃𝗶𝗼𝗹𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗼𝘂𝗻𝗱 𝘁𝗵𝗲 𝘄𝗼𝗿𝗹𝗱 to provide new evidence against official narratives in international human rights courts.

Listen in to the conversation he had with at aksioma.org/podcast/reprogramm

2023-11-18

IGF2BP2-meidated m6A modification of CSF2 reprograms MSC to promote gastric cancer progression. doi.org/10.1038/s41419-023-061 #MesenchymalStemCells #Reprogramming

article figure
Aksiomaaksioma
2023-11-17

In a media landscape dominated by social media, we want everything to go viral, but small groups of well-organised people can have a larger impact than millions protesting in the streets or online.

In the 7th podcast we talk about . ’s guest is , an international filmmaker, writer and political organiser.

👂 Listen at: aksioma.org/podcast/reprogramm

Aksiomaaksioma
2023-11-10

What happens when we purchase an item on Amazon? Who owns the profile images posted on dating apps? How many trees are needed to absorb the amount of CO2 generated by the global visits to Google every second?

Through the artistic outputs of her findings, transforms these revelations into tangible concepts fostering awareness in the collective consciousness of the footprint caused by our use of the Cloud.

aksioma.org/podcast

Aksiomaaksioma
2023-11-03

Far from being immaterial, AI is made of flesh, sweat and fossil fuels, and is not neutral. Also, AI stands as one of the most concentrated industries of the world.

👂 Tune in to the new episode. Listen at: aksioma.org/podcast

hosts a leading scholar on the social implications of artificial intelligence ; and some special guests with questions related to the topic.

Aksiomaaksioma
2023-10-27

New podcast!

talks with , whose work transports people into the future.

aksioma.org/podcast

Jain is a designer, a filmmaker & co-founder of , a speculative design studio that explores the intersections of climate crisis, technology and more-than-human politics. In this episode she gives the listeners an emotional vade mecum to imagine and possibly shape the future [...]

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