No te pierdas la Videoteca de Cáncer de Pulmón en en Español 2025, donde oncólogos discuten las opciones de tratamiento y información más emergentes en cáncer de pulmón.
En este video, el Dr.
@LuisRaezMD
analiza la forma en que se desarrollaron las opciones de tratamiento para pacientes con #cáncerdepulmón de células no pequeñas #EGFR.
Mira el video completo aquí: https://youtube.com/watch?v=l7YtTKdPl-0
Our amazing Brittany recording with Dr. Jinyong Kim (김진영) from Samsung Medical Center (삼성서울병원) in Korea.
She discussed updates on patients with NSCLC harboring EGFR mutations.
Stay tune for the complete Video Library coming soon!
The Texas State Plan for #CKD #Chronic #Kidney #Disease Treatment, is 🔥 💪
www.hhs.texas.gov/sites/defaul...
Key points:
1) Expands early screening
2) Acknowledges socioeconomic factors in CKD
3) Integrates #proteinuria #EGFR & #genetics
4) School screening for proteinuria & #hypertension
hhs.texas.gov/sites/default/...
The Texas State Plan for #CKD #Chronic #Kidney #Disease Treatment, is 🔥 💪
https://www.hhs.texas.gov/sites/default/files/documents/state-plan-ckd-treatment-jan-2025.pdf
Key points:
1) Expands early screening
2) Acknowledges socioeconomic factors in CKD
3) Integrates #proteinuria #EGFR & #genetics
4) School screening for proteinuria & #hypertension
🫁 🦀 Aujourd'hui dans le rendez-vous mensuel des Mardis du GOLF (Groupe Oncologie Langue française ) de la SPLF Actualités dans la prise en charge des cancers broncho-pulmonaires mutés EGFR par Jacques Cadranel
⚡ 👉À 13h : https://splf-live.org/
mais aussi en 👀 👉replay et podcast : https://lnkd.in/duX86JX
et 👂version audio : 👉 https://lnkd.in/eVsWWrVm
#EGFR#mutations #oncologie #thoracique #respiratoire #cancer #poumons #thérapeutique #tumeur#traitements
#Phoenix_Fluor#555: Ultra-photostable fluorescent molecule reveals hidden dynamics of #intracellular #proteins.
https://phys.org/news/2025-02-phoenix-fluor-ultra-photostable-fluorescent.html
Nel DNA la predisposizione per la dieta vegetariana. La dieta vegetariana è più salutare? Dipende dai tuoi geni. Abbiamo scoperto che alcune varianti genetiche influiscono sul modo in cui assorbiamo i nutrienti, capovolgendo gli effetti della dieta vegetariana sull'organismo.
#eGFR #geneMMAA #genetica #nutrigenetica #testosterone #vegetariani
https://scienzamagia.eu/sociale-collettivita/nel-dna-la-predisposizione-per-la-dieta-vegetariana/
A stealth #fungus has decimated North American #bats, but scientists may be a step closer to treating #white_nose syndrome.
#epizootic #Pseudogymnoascus #infection #keratinocytes #EGFR
https://phys.org/news/2024-07-stealth-fungus-decimated-north-american.html
Antibody Drug Conjugates: What Are Antibodies? - OncTalk Lung 2023 https://youtu.be/T3oJcRdGoWo?si=48eXvKTbEQLXPXBC via @YouTube
In this video, Dr. Lyudmila Bazhenova gives a quick overview of what antibodies are, and how they kill cancer cells.
For more, please visit http://cancerGRACE.org/.
To join the conversation, visit https://cancergrace.org/forum. #lungcancer #nsclc #EGFR
Lung Resection in Early Stage NSCLC: An Overview - OncTalk Lung 2023 https://youtu.be/s37tMBHZVnY?si=hsSGgkymLKYX18DF via @YouTube
In this video, Dr. Jeff Yang gives a brief overview of the treatability of early-stage NSCLC, the use of lung resection, and basic lung anatomy.
For more, please visit http://cancerGRACE.org/.
To join the conversation, visit https://cancergrace.org/forum. #lungcancer #nsclc #EGFR
A recently developed ⭐️#cancer #vaccine for dogs⭐️ is showing promising results in clinical trials, which have been running since 2016, and there's hope that some of the benefits of the vaccine could be translated into human cancer treatments.
More than 300 dogs have been treated with the vaccine to date, and the twelve--month survival rate for canines with certain cancers has been lifted from about 35 percent to 60 percent. Tumors in many of the animals have also shrunk.
Known officially as the #Canine #EGFR/#HER2 #Peptide #Cancer #Immunotherapeutic, the treatment grew out of studies of autoimmune diseases, where the immune system damages the body's own tissue rather than any invading threats.
The vaccine is designed to get the immune system to attack cancer instead.
In many ways tumors are like the targets of autoimmune diseases," says rheumatologist #Mark #Mamula, from the Yale University School of Medicine.
"Cancer cells are your own tissue and are attacked by the immune system. The difference is we want the immune system to attack a tumor."
As outlined in a 2021 study by Mamula and colleagues, the treatment gets the immune cells to produce antibody defenses, which attach themselves to tumors and interfere with their growth patterns.
Specifically, these antibodies hunt down two proteins: 🔸epidermal growth factor receptor 🔸( #EGFR ) and 🔸human epidermal growth factor receptor 2🔸 ( #HER2 ).
Mutations causing overexpression of these proteins drive uncontrolled cell division in some human and canine cancers.
Novel technology allows comprehensive analysis of #membrane #protein #extracellular interactions.
https://phys.org/news/2024-02-technology-comprehensive-analysis-membrane-protein.html
IS YOUR KIDNEY OK?🔥#egfr #kidney #kidneyhealth #kidneydisease
#EGFR signaling controls directionality of #epithelial multilayer formation upon loss of cell polarity in the #Drosophila follicular epithelium
Aiguo Tian, Wu-Min Deng et al
Next: large database study on age-related normal decline in #eGFR.
I’m sure Prof. Glassock would like this.
I forgot to ask if there will be a calculator!
New ChemRxiv preprint! “Pitfalls and considerations in determining the potency and mutant selectivity of covalent #EGFR inhibitors.” Collaboration between our group and AssayQuant Technologies, Inc. #MedicinalChemistry #oncology https://chemrxiv.org/engage/chemrxiv/article-details/64e50861dd1a73847f5020a1
The EGFR #phosphatase RPTPγ is a #redox-regulated suppressor of promigratory signaling
Maitreyi Joshi, Philippe Bastiaens et al show that #RPTPγ is coupled to autocatalytic, ligandless #EGFR #phosphorylation by a ROS-mediated toggle-switch, enabling ultrasensitive EGFR activation at the plasma membrane
https://www.embopress.org/doi/10.15252/embj.2022111806
Online today!
Lung cancer cells exposed to #PM2.5 for 90 days were used as a model of the effects of long-term exposure to PM2.5 on #LungCancer. In mice, tumor progression was enhanced by long-term exposure to PM2.5. The molecular mechanism identified may include (i) activation of #EGFR signaling & (ii) activation of AhR to upregulate TMPRSS2, which in turn upregulates its downstream targets, such as #IL18.
By PC Yang, CY Chen & colleagues, Taiwan
Modeling & experimental analyses of a Golgi-localized GTPase circuitry that allows cancer cells to achieve self-sufficiency in growth factor signaling ➡️ http://bit.ly/41DK7Dj
P Rangamani & P Ghosh, UCSD
#Gproteins #CellSignaling #EGFR #SystemsBiology
"Using novel humanized IBC mouse models, we discovered that EGFR-targeted therapy remodels the IBC TME by increasing cytotoxic T cells and reducing immunosuppressive regulatory T cells and M2 macrophages. These changes were due to diminishing immunosuppressive chemokine expression regulated by transcription factor EGR1. We also showed that induction of an immunoactive IBC TME by an anti-EGFR antibody improved the antitumor efficacy of an anti–PD-L1 antibody."
#Immunology #Immunotherapy #EGFR #DrugDevelopment #MonoclonalAntibody
