@celineh2ooo.bsky.social and @stevensalzberg.bsky.social compared 3,493 vertebrate genomes to identify 342 gains of introns in human genes, tracing their origins and identifying cases of intronization as a mechanism of intron emergence.
🔗 doi.org/10.1093/gbe/evaf091
Double-stranded DNA viruses may serve as vectors for horizontal transfer of intron-generating transposons.
#Transposons #Introners #Introns #dsDNAviruses #HorizontalGeneTransfer #Dinoflagellates #Preprint
https://www.biorxiv.org/content/10.1101/2025.03.18.643946v1
When your body turns your DNA into one of many alternate protein forms, it uses this finely tuned biomachinery for a rope dance with the mRNA strand to carry out very coordinated cuts and joins.
Absolutely incredible to see it animated with this level of detail :0
#RNA #spliceosome #structuralbiology #animation #exons #introns #alessoninthelariat
"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA
Scientists reveal how #RNA gets #spliced correctly.
https://phys.org/news/2023-11-scientists-reveal-rna-spliced.html
Heat stress? More like hot new #PlantScience !
💥🌡️🌱
Spend the weekend with #JIPB and find out how #spliceophilin CYP18‐2 is involved in the splicing of retained #introns under heat stress in #Arabidopsis.
https://jipb.net/EN/10.1111/jipb.13450
@wileyplantsci
#AbioticStress #thermotolerance
Pictures Considered #58: Visualizing Introns
by Christoph
By reading sequences we easily detect stretches that code for proteins. We detect promoters, transcription factor binding motifs, start/stop signals for transcription, signals where introns are removed by splicing from primary transcripts (pre‑mRNA) to yield mature messenger RNA (mRNA), and much more. It wasn't always so easy.
Read more → https://tinyurl.com/4s5zebxr
Researchers reveal structural mechanism of #Tetrahymena #ribozyme self-#splicing reaction.
https://phys.org/news/2023-04-reveal-mechanism-tetrahymena-ribozyme-self-splicing.html
A New Model Offers an Explanation For The Huge Variety of Sizes of DNA in Nature:
A new model offers a possible solution to the scientific question of why neutral sequences, sometimes referred to as 'junk DNA', are not eliminated from the genome of living creatures in nature and continue to exist within it even millions of years later
https://royalsocietypublishing.org/doi/10.1098/rsob.220223
#genetics #genetic #molecularbiology #cellbiology #introns #dna
🌡️When things get hot, we're not just splicin'...we're *#spliceophilin*🎤
Lee et al. report on the role of spliceophilin CYP18-2 in the splicing of retained #introns under #HeatStress in #Arabidopsis. https://doi.org/10.1111/jipb.13450
@wileyplantsci
#PlantScience #JIPB #GeneEditing
"Transposable elements drive intron gain in diverse eukaryotes" #PNAS #introns #transposons
"...Introners evolved convergently from many distinct genetic elements, most are consistent with DNA-based transposable elements, and they are disproportionately common in the genomes of aquatic organisms. We propose that horizontal transfer of transposons in aquatic taxa contributes to the biased and highly punctate evolution of intron gains across eukaryotes."
Long-standing #genomics mystery about the origins of #introns explained in new study
https://phys.org/news/2022-11-long-standing-genomic-mystery-introns.html
#TransposableElements drive #intron gain in diverse eukaryotes https://www.pnas.org/doi/10.1073/pnas.2209766119
The researchers believe that #introners (specialized #transposons) are the only likely explanation for intron burst events, in which thousands of introns show up in a #genome seemingly all at once, and they find evidence of this in species across the eukaryotic tree of life.
