The poster pitches at #NWOCHAINS were an absolute firework of great #science on #antivirals, #organocatalysis, #MolecularMotors, #EnzymeEngineering, #photocontrol, #odor, #bacteria, #recycling, #batteries, #QuantumDots, #vitrimers, #BoneRegeneration, native #MassSpectrometry and #biomaterials.

The poster pitches at #NWOCHAINS were an absolute firework of great science. We learned about #antivirals, #organocatalysis, #MolecularMotors, #EnzymeEngineering, #photocontrol, #odor detection, sensing of #bacteria, #recycling, #batteries, #QuantumDots, #vitrimers, #BoneRegeneration, native #MassSpectrometry and #biomaterials. Always one of my highlights of the conference.

#Chemistry #ChemBio #ECR #PosterPitch

🧪 Can ionic liquids fine-tune enzyme activity and chirality without genetic modification?

🔗 Influence of ionic liquids on enzymatic asymmetric carboligations. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.029

📚 CSBJ: https://www.csbj.org/

#Biocatalysis #EnzymeEngineering #GreenChemistry #IonicLiquids #EnzymeCatalysis #MolecularDynamics #StructuralBiology #ComputationalBiology #ProteinEngineering #AsymmetricSynthesis #Enzymology

⚙️ Is enzyme catalysis powered by thermal noise rather than chemical stability?

🔗 Dynamic energy conversion in protein catalysis: From brownian motion to enzymatic function. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.050

📚 CSBJ: https://www.csbj.org/

#ProteinDynamics #EnzymaticCatalysis #Biophysics #StructuralBiology #DrugDiscovery #EnzymeEngineering #Biochemistry

🧬 How does protein flexibility unlock enzyme promiscuity?

🔗 Protein flexibility drives sugar rotation and high substrate promiscuity in a GDP-sugar 4-epimerase. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.037

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #EnzymeEngineering #RareSugars #ProteinDynamics #Biotechnology

Engineering a Decarboxylative Aldolase for the Synthesis of Cyclic Imino Acids:
Divergent regioselectivity and diastereoselectivity compared to the wild-type enzyme achieved
https://www.chemistryviews.org/engineering-a-decarboxylative-aldolase-for-the-synthesis-of-cyclic-imino-acids/

#biocatalysis #enzymeengineering #chemistry #chemistryviews #chemviews

The era of #proteindesign really is coming along nicely.

#proteinengineering
#enzymeengineering

https://www.nature.com/articles/s41586-023-05696-3

Twitter thread from Institute for Protein Design
https://twitter.com/UWproteindesign/status/1628438074404507648?t=goy2swbeDBU7nux-nmG9jg&s=19

Excited to share my very first paper which was just published in #JACS:

https://pubs.acs.org/doi/10.1021/jacs.2c10673

In this work carried out during my PhD together with Jamie Klein, Tomasz Kaminski, and Pierre-Yves Colin in the Hollfelder Lab at #UniversityofCambridge we evolve a #phosphotriesterase with a new, metal-independent mechanism by using droplet #microfluidics.

Comments and feedback welcome! A thread: (1/6)

#EnzymeEngineering #ProteinEngineering #EnzymeMechanism #DirectedEvolution #Bioremediation

The innophore teams CavitOmiX for your #PyMol cavities
#StructuralBiology
@structbio
#proteinstructureandfunction
#enzymeengineering

https://pymolwiki.org/index.php/CavitOmiX

David Bakers talk
"The coming of age of de novo protein design" at the NIH from Dec. 14th

@strucbio

https://videocast.nih.gov/watch=46050

#proteindesign #enzymeengineering

@greenkidneybean

One for the @strucbio people perhaps 😀

#enzymeengineering
#proteindesign
#structuralbiology

#gptchat on #enzymeengineering

This is kind of fun.

But also there are some obvious limitations. Still shallow waters.

Generated by https://chat.openai.com
With the prompt:
"Write a poem on enzyme engineering"

#enzymes #ai #gpt3