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Tom Kindlontomkindlon@disabled.social
2025-06-22

Employers’ Long Game for Long Covid

journals.sagepub.com/doi/full/

Image is from the latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

American Journal of Health Promotion Employers’ Long Game for Long Covid — Scott Conard et al. "Employers can play a role in retaining employees with Long COVID and supporting their health and well-being by acknowledging what they are going through, offering accommodations and flexibilities, and choosing health plans that meet the needs of people with Long COVID."
Tom Kindlontomkindlon@disabled.social
2025-06-21

"The results showed the significant productivity loss caused by missed workdays due to #longCOVID, providing an economic justification for policymakers and employers to provide support systems for long #COVID patients to return to work."

journals.plos.org/plosone/arti

Image from latest Science for ME weekly update

@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID_19 #COVIDー19 #SARSCoV2

PLOS ONE Long-COVID is associated with increased absenteeism from work — Jaewhan Kim et al. "This study used a national survey data to find that individuals with long-COVID experienced additional days missed from work compared to those without long-COVID. The results showed the significant productivity loss caused by missed workdays due to long-COVID, providing an economic justification for policymakers and employers to provide support systems for long-COVID patients to return to work."
Tom Kindlontomkindlon@disabled.social
2025-06-21

Postacute Sequelae of COVID-19 Across 12 Major Health Domains and 141 Diseases in Individuals With Mental Illness Among COVID-19 Survivors: A Population-Based Cohort Study in South Korea

doi.org/10.1002/jmv.70406

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

Journal of Medical Virology Postacute Sequelae of COVID-19 Across 12 Major Health Domains and 141 Diseases in Individuals With Mental Illness Among COVID-19 Survivors: A Population-Based Cohort Study in South Korea — Jiseung Kang et al. "Understanding whether individuals with mental illness, who face challenges related to healthcare barriers, are more vulnerable to postacute sequelae of COVID-19 is limited. Here, we investigated the potential association between pre-existing mental illness and postacute sequelae of COVID-19 across 12 major health domains and 141 specific diseases in COVID-19 survivors."
Tom Kindlontomkindlon@disabled.social
2025-06-20

Florida, USA

People who had COVID at anytime & recovered (no persistent symptoms that started with acute #COVID) are sought for $4m CDC-funded study. These ME/CFS-aware researchers want to compare #longCovid to ME/CFS but need controls

Survey link:
redcap.nova.edu/redcap/surveys.

Please share widely

#MEcfs @mecfs @longcovid #PASC #PwLC #postcovid #postcovid19 #LC #PostCovidSyndrome #COVIDBrain #NeuroPASC @covid19 #Coronavirus #COVID19 #COVID #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver

COVID-UPP Study We’re nearing the finish line on our important CDC study designed to compare Long COVID to ME/CFS — a vital step toward advancing our mission. But we still need healthy control participants! We are looking for anyone who had COVID at anytime and recovered (no persistent symptoms that started with acute COVID). We particularly need: males between 55-65 years old and females between 18-50 years old. The study involves filling out health related surveys and spending a half day at our clinic (Davie or Kendall) completing on-site tests. Our evaluation includes a physical exam, cognitive tests, spirometry etc. There is a financial compensation for your time. Thank you for considering this opportunity and helping spread the word! If you’re interested in participating, please complete our COVID-UPP survey: HERE If you have any questions please email our team at postcoviduppstudy@nova.edu.
Tom Kindlontomkindlon@disabled.social
2025-06-20

"Our data show #SARSCoV2 N protein exacerbates pathological pain in mouse models of bone cancer, chemotherapy, neuropathic, & inflammatory, & promotes the chronification of acute inflammatory pain"

journals.lww.com/pain/fulltext

Image from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

PAIN SARS-CoV-2 N protein interacts with Nav1.7 to promote pathological pain — Liu, Jin-Kun et al. "Our data show that SARS-CoV-2 N protein exacerbates pathological pain in mouse models of bone cancer, chemotherapy, neuropathic, and inflammatory, and promotes the chronification of acute inflammatory pain. We also identify a potential interaction between the N protein and Nav1.7 in dorsal root ganglion neurons from mice, monkeys, and humans."
Tom Kindlontomkindlon@disabled.social
2025-06-20

"the proportion of children in the survey who reported good or very good health reduced from 82.6% before NZ's two large Omicron waves to 66.9% after these waves"

onlinelibrary.wiley.com/doi/10

Image from @s4me update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19
#LongCovidKids #LCKids

Journal of Paediatrics and Child Health Post-Covid-19 Symptoms in Children: A Cross-Sectional Survey — Julie Bennett et al. "the proportion of children in the survey who reported good or very good health reduced from 82.6% before NZ's two large Omicron waves to 66.9% after these waves, with changes in health significantly more frequent in those who had a Covid-19 infection compared with those who had not."
Tom Kindlontomkindlon@disabled.social
2025-06-18

"In this paper, it is hypothesized that reduced oxygen tension in skeletal muscle is indicative of COVID-19 disease severity and predictive of subsequent progression in severity of illness"

sciencedirect.com/science/arti

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

Medical Hypotheses Skeletal muscle oxygen tension as a measure of COVID-19 disease severity and predictor of disease progression — Stacey et al. "In this paper, it is hypothesized that reduced oxygen tension in skeletal muscle is indicative of COVID-19 disease severity and predictive of subsequent progression in severity of illness."
Tom Kindlontomkindlon@disabled.social
2025-06-18

From India:

Executive Function Decline and Its Association With TNF-α in the Later Stages of Post-Acute Sequelae of COVID

onlinelibrary.wiley.com/doi/ab

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Journal of Neuroscience Research Executive Function Decline and Its Association With TNF-α in the Later Stages of Post-Acute Sequelae of COVID — Aditi Varenya et al. "EF decline in PASC also showed a significant, moderate, inverse relationship with serum TNF- α levels. No such correlations were observed in the HC group. Furthermore, serum TNF- α levels were significantly predictive of the variance in EF decline, after controlling for the impact of age and education" "Notably, serum TNF- α concentrations were significantly higher in females, relative to males, in the PASC group."
Tom Kindlontomkindlon@disabled.social
2025-06-18

From Italy:

Post-COVID-19 exaggerated exertional tachycardia: Relationship with pulmonary and cardiac sequelae

heartandlung.org/article/S0147

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19 #auscovid19

Heart & Lung: The Journal of Cardiopulmonary and Acute Care Post-COVID-19 exaggerated exertional tachycardia: Relationship with pulmonary and cardiac sequelae — Giovanna Pelà et al. "We found a significant reduction in lung diffusion capacity and in mean oxygen saturation during the 6MWT in [Exaggerated Exertional Tachycardia] patients compared to [Normal Exertional Tachycardia] ones."
Tom Kindlontomkindlon@disabled.social
2025-06-18

Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes

pubs.acs.org/doi/full/10.1021/

Image is from the latest Science for ME weekly update

#LongCovidKids #MIS_C #LCKids @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Journal of Proteome Research Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes — Nathan G. Lawler et al. "We provide comprehensive metabolic profiles of children with acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C) resulting from acute COVID-19 infection, revealing both have significant metabolic perturbations similar to those seen in adults." "The persistence of inflammatory and cardiovascular markers postinfection raises concerns about long-term health impacts, underscoring the need for vigilant monitoring, potential interventions, and further studies to understand the lasting effects of SARS-CoV-2 infection on pediatric health."
Tom Kindlontomkindlon@disabled.social
2025-06-18

COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID

Image is from the latest Science for ME weekly update

biorxiv.org/content/10.1101/20

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19 #auscovid19

Preprint: BioRxiv COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID — Soneida DeLine-Caballero et al. "our results revealed no evidence of persistent viral RNA in [subcutaneous adipose tissue] samples from either subacute or LC cohorts." "Transcriptome analysis of SAT samples did not distinguish participants with significant LC symptoms from indeterminant subjects. These findings suggest that SAT remodeling does not play a major role in driving Long COVID sequelae."
Tom Kindlontomkindlon@disabled.social
2025-06-18

New US research

SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19

biorxiv.org/content/10.1101/20

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver @auscovid19 #auscovid19

Preprint: BioRxiv SARS-CoV-2-induced dysregulation in ADAR editing patterns persists post viral clearance in individuals with mild COVID-19 — Aiswarya Mukundan Nair and Helen Piontkivska "Our results suggest that SARSCoV-2 infection can lead to persistent changes in ADAR editing patterns even after viral clearance." "we propose persistent dysregulation in ADAR editing of host transcripts, including in genes involved in the neutrophil degranulation pathway, as one potential contributor to some of the symptoms observed in post-SARS-CoV-2 infection sequelae in a subset of individuals."
Tom Kindlontomkindlon@disabled.social
2025-06-16

The Bethesda Declaration:
"Based on political preferences and without input from NIH scientific staff or Congress, NIH is censoring critical research and programs addressing: #COVID19, #longCOVID, and immunization"

standupforscience.net/bethesda

s4me.info/threads/impacts-of-t

Image from Science for ME update

#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver

Stand Up For Science The Bethesda Declaration: A Call for NIH and HHS Leadership to Deliver on Promises of Academic Freedom and Scientific Excellence A group of NIH employees have written an open letter addressed Dr. Bhattacharya, director of the National Institutes of Health. The letter includes this section: "Based on political preferences and without input from NIH scientific staff or Congress, NIH is censoring critical research and programs addressing: - COVID-19, long COVID, and immunization. We still have much to learn about the health and social consequences of COVID-19 and our response. Such research is needed to reduce the risk of future pandemics, optimize pandemic response policies, and address the well-documented and debilitating consequences of long COVID." The forum thread includes links to multiple news outlets that have covered this story. Bethesda Declaration | Thread
Tom Kindlontomkindlon@disabled.social
2025-06-15

Creatine and Post-Viral Fatigue Syndrome: Can a Gym Supplement Support Brain Recovery?

propstmetabolichealth.substack

Comment: I've been taking 12 g/day of Creatine for many months now (with a break every 6 weeks).
This may be contributing to me feeling better.

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

1/

Creatine and Post-Viral Fatigue Syndrome: Can a Gym Supplement Support Brain Recovery? David Propst Jun 07, 2025 A month ago, I shared a post exploring the potential of creatine in managing post-viral fatigue. Just yesterday, an updated peer-reviewed study was published and it adds important new insights. Published in the Journal of the International Society of Sports Nutrition, the paper dives deeper into creatine’s role in energy metabolism, cognitive recovery, and long COVID–related fatigue. Let’s break down what’s new, what it confirms, and what it means for anyone navigating post-viral fatigue.
Tom Kindlontomkindlon@disabled.social
2025-06-13

"Emergency departments aren’t trained for Long COVID [& ME/CFS] — and patients are paying the price" by @thesicktimes

thesicktimes.org/2025/06/02/em

Among other things, recommends more medical education for healthcare staff in emergency rooms & elsewhere, plus better access to telehealth

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

1/

Emergency departments aren’t trained for Long COVID — and patients are paying the price Written by Lauren May – June 2, 2025 Graphic showing a red cross with a large crack running through its center, against a backdrop with small white coronavirus particles on an orange background Miles Griffis / The Sick Times
Tom Kindlontomkindlon@disabled.social
2025-06-13

🧵
I thought this was good (as I'd expect from Oonagh & #ThereForME team):

"The importance of understanding rest: How my experience of rest as an athlete clashed with my experience of rest as a patient"

thereforme.uk/p/the-importance

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@chronicillness
@spoonies

1/

The importance of understanding rest How my experience of rest as an athlete clashed with my experience of rest as a patient Oonagh Cousins Jun 10, 2025 Today’s post is from our very own Oonagh Cousins, a member of the #ThereForME HQ team. Oonagh is a former professional athlete with the British Rowing team and was pre-selected for the Tokyo Olympics before her career was cut short by Long Covid, which she contracted in March 2020. After nearly three years of attempting to recover and return to elite sport, she made the decision to retire at the end of 2022. Since then, she has focused her efforts in the Long Covid and ME space – working at the charity Long Covid Support, as part of a social science research team at the University of Oxford, and in the #ThereForME team.
Tom Kindlontomkindlon@disabled.social
2025-06-13

US research:

"our findings suggest that the persistence of #SARSCoV2 N-protein in peripheral blood promotes a chronic inflammatory milieu, even several months after active infection..."

biorxiv.org/content/10.1101/20

Image from Science for ME update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Preprint: BioRxiv The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction — Andreas Koenig et al. "our findings suggest that the persistence of SARS-CoV-2 N-protein in peripheral blood promotes a chronic inflammatory milieu, even several months after active infection via MAVS-mediated type I IFN production that could contribute, in susceptible individuals, to the development of autoimmunity."
Tom Kindlontomkindlon@disabled.social
2025-06-13

Perspective: host factors variants and the underlying causes of long COVID

frontiersin.org/journals/medic

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Frontiers in Medicine Perspective: host factors variants and the underlying causes of long COVID — Pasharawipas "The concept of host factor variants, including variations in cellular molecules and major histocompatibility complex (MHC) polymorphisms, has been proposed to explain the variable symptoms in SARS-CoV-2-positive individuals. This article expands on this concept to explain the causes of long COVID, particularly focusing on the roles of cytotoxic T cells (Tc), helper T cells (Th), and antigen presenting cells (APCs)"
Tom Kindlontomkindlon@disabled.social
2025-06-13

From Estonia:

Long COVID and Biomarker Dysregulation—A Shift Toward Immune Exhaustion?

mdpi.com/1648-9144/61/6/996

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19 #auscovid19

Medicina Long COVID and Biomarker Dysregulation—A Shift Toward Immune Exhaustion? — Kallaste et al. "Our findings suggest that inflammation-related biomarker dysregulation following acute SARS-CoV-2 infection evolves dynamically over a six-month period. By the sixth month, compared to the third month, the presence of LC is more accurately predicted by a combination of persistent biomarker alteration and the severity of the initial infection, as defined by WHO criteria."
Tom Kindlontomkindlon@disabled.social
2025-06-13

US research

IgA autoimmunity and coagulation among post-acute sequelae of SARS-CoV-2 infection (PASC) patients with persistent respiratory symptoms: a case-control study

frontiersin.org/journals/immun

Image is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver @auscovid19 #auscovid19

Frontiers in Immunology IgA autoimmunity and coagulation among post-acute sequelae of SARS-CoV-2 infection (PASC) patients with persistent respiratory symptoms: a case-control study — Gomes et al. "we found that IgA antibodies correlate inversely with clinical symptoms and directly with clotting parameters, suggesting a possible link between autoimmunity and coagulation, but in a unexpected direction as lower levels of IgA predicted more respiratory symptoms among PASC cases."

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