Comparative #pathogenicity of three A(#H5N1) clade 2.3.4.4b HPAI viruses in blue-winged #teal and #transmission to domestic #poultry, https://etidiohnew.blogspot.com/2025/05/comparative-pathogenicity-of-three.html

#Pathogenicity and #transmissibility of bovine-derived HPAI #H5N1 B3.13 virus in #pigs, https://etidiohnew.blogspot.com/2025/05/pathogenicity-and-transmissibility-of.html

🛡️Understanding #plant-#pathogen interactions will help us protect crucial #food #crops

🌾Shu et al. characterize a #MAPK signaling cascade that contributes to #wheat stripe rust resistance, providing new insights into crop immunity and the #pathogenicity of an obligate biotrophic #fungus.

https://doi.org/10.1111/jipb.13888
@wileyplantsci
#PlantSci #JIPB #botany

Superior #replication, #pathogenicity, and immune #evasion of a #Texas dairy #cattle #H5N1 virus compared to a historical avian isolate, https://etidiohnew.blogspot.com/2025/03/superior-replication-pathogenicity-and.html

#Pathogenicity and #transmissibility of #bovine-derived HPAI #H5N1 #B3.13 virus in #pigs, https://etidiohnew.blogspot.com/2025/03/pathogenicity-and-transmissibility-of.html

Identification of Aminoacid #Residues Responsible for Differential #Replication & #Pathogenicity of Avian #Influenza Virus #H5N1 Isolated from #Human & #Cattle in #Texas, https://etidiohnew.blogspot.com/2025/03/identification-of-aminoacid-residues.html

#Pathogenicity of Novel #H3 Avian #Influenza Viruses in #Chickens and Development of a Promising #Vaccine, https://etidiohnew.blogspot.com/2025/02/pathogenicity-of-novel-h3-avian.html

Deglycosylation and #truncation in the #neuraminidase #stalk are functionally equivalent in enhancing the #pathogenicity of a HPAI virus in #chickens, https://etidiohnew.blogspot.com/2025/02/deglycosylation-and-truncation-in.html

#Replication kinetics, #pathogenicity and virus-induced cellular responses of #cattle-origin #influenza A(#H5N1) isolates from #Texas, #USA, https://etidiohnew.blogspot.com/2025/01/replication-kinetics-pathogenicity-and.html

A low pathogenic avian #influenza A/Mallard/South Korea/KNU2019-34/2019 (#H1N1) virus has the potential to increase the #mammalian #pathogenicity, https://etidiohnew.blogspot.com/2024/12/a-low-pathogenic-avian-influenza.html

The #evolution of #hemagglutinin-158 and #neuraminidase-88 #glycosylation sites modulates antigenicity and #pathogenicity of clade 2.3.2.1 #H5N1 avian #influenza viruses, https://etidiohnew.blogspot.com/2024/12/the-evolution-of-hemagglutinin-158-and.html

#Origin, #pathogenicity, and #transmissibility of a #human isolated #influenza A(#H10N3) virus from #China, Emerg Microbes Infect.: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2432364

Human isolated H10N3 also showed respiratory #droplet #transmissibility in #ferrets. Considering continuous circulation in avian populations and repeated transmission to humans, strengthened #surveillance of H10 subtype viruses in poultry should be put into effect.

#SARS-CoV-2 #JN1 reveals attenuated #pathogenicity and #airborne #transmission

Source: BioRxIV, AbstractJN.1 is a subvariant of SARS-CoV-2 Omicron BA.2.86 lineage that was predominant worldwide in early 2024, of which the in vivo characteristics are largely unknown. Our results demonstrated that the replication of JN.1 was more efficient than that of the parental BA.2 in Vero cells, which demonstrated low dependence on TMPRSS2. Compared to Omicron variants BA.2 and XBB…

https://etidioh.wordpress.com/2024/11/09/sars-cov-2-jn1-reveals-attenuated-pathogenicity-and-airborne-transmission/

#Replication #Kinetics, #Pathogenicity and Virus-induced Cellular Responses of #Cattle-origin #Influenza A(#H5N1) Isolates from #Texas, United States

Source: BioRxIV, AbstractThe host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States. Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the cattle-origin influenza…

https://etidioh.wordpress.com/2024/10/30/replication-kinetics-pathogenicity-and-virus-induced-cellular-responses-of-cattle-origin-influenza-ah5n1-isolates-from-texas-united-states/

#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

#Hemagglutinin and #neuraminidase of a non-pathogenic #H7N7 avian #influenza virus coevolved during acquisition of intranasal #pathogenicity in #chickens, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06118-z

This study demonstrates that viruses that are highly pathogenic when administered intranasally require additional adaptations for increased pathogenicity to be highly lethal to intranasally infected chickens.

#Pathogenicity of HPAI #H5N1 Viruses Isolated from #Cats in Mice & #Ferrets, S #Korea, 2023, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/10/24-0583_article

H5N1 clade 2.3.4.4b viruses isolated from 2 cats harbored mutations in the PB2 gene encoding single amino acid substitutions E627K or D701N, which are associated with virus adaptation in mammals. We analyzed pathogenicity & transmission of cat-derived viruses in other mammals. Both isolates caused fatal infections in mice & ferrets.

#Molecular basis of #pathogenicity of recently emerged #FCoV23 #coronavirus, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.25.607996v1

FCoV-23 is a recently emerged, highly pathogenic #recombinant coronavirus responsible for a widespread #outbreak of #feline infectious #peritonitis (FIP) likely linked to in-host viral evolution. Here, we report cryoEM structures of two FCoV-23 spike (S) isoforms explaining that the in-host loss of domain 0 observed in clinical samples enhances entry into cells ...

Effective management of #Salmonella infections requires understanding its dynamic evolution. @simrankushwaha @NobregaFL &co reveal how specific genomic regions influence the distribution of #pathogenicity factors in Salmonella #PLOSBiology https://plos.io/3WAHZdT

Evaluating #epizootic & #zoonotic #threat of an #H7N9 #LPAIV #variant associated with enhanced #pathogenicity in #turkeys. J Gen Virol.: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.002008

H7N9 infection in turkeys can generate novel variants with increased #risk through altered pathogenicity and potential HA antigenic #escape. These findings emphasize the requirement for enhanced #surveillance and understanding of A/Anhui/1/13-lineage viruses and their risk to different species.