Currently, #antibiotics are the only way to effectively treat #typhoid, which is caused by the bacterium Salmonella enterica serovar Typhi (S Typhi). Yet over the past three decades, the bacterium's resistance to oral antibiotics has been growing and spreading.
In their study, researchers sequenced the genomes of 3,489 S Typhi strains contracted from 2014 to 2019 in Nepal, Bangladesh, Pakistan, and India, and found a rise in extensively drug-resistant (XDR) Typhi.
https://www.sciencealert.com/ancient-killer-is-rapidly-becoming-resistant-to-antibiotics-study-warns