🧬 Ubiquitin Precursor: A Key to Healthy Aging?
Researchers from the #UniCologne and the Heinrich-Heine-Universität Düsseldorf have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging. This discovery opens up potentially new perspectives for the treatment of cancer and age-related diseases.

Read more ▶️ https://uni.koeln/BLXJA

📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373

#uniköln #unicologne #Research #Ubiquitin #Cancer #Aging #Health #proteostasis

🧬 Ubiquitin-Vorläufer: Ein Schlüssel zum gesunden Altern?
Forscher*innen der #UniKöln und der @HHU haben eine neue Form des Proteins Ubiquitin identifiziert, die für die Proteostase und gesundes Altern verantwortlich ist. Diese Entdeckung eröffnet potenziell neue Perspektiven für die Behandlung von Krebs und altersbedingten Krankheiten.

Mehr dazu ▶️ https://uni.koeln/AALLM

📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373

#uniköln #unicologne #Forschung #Krebs #Altern #Gesundheit #Ubiquitin

The Level of Ubiquitin Conjugates in Murine Blood Serum: Relevance to Radioprotection and Age-Related Variability - #ubiquitin #ubiquitinconjugates #irradiation #responsetoradiation #agerelateddifferences #murinebloodserum #bloodserum #blood #Musmusculus #Mus - https://link.springer.com/article/10.3103/S0095452725010049

🦠🔬 Forschungsteam entdeckt Trick von Bakterien zum Überleben in der Wirtszelle
Ein Forschungsteam der Universität zu Köln und Leiden hat eine Strategie von Bakterien entdeckt, um sich langfristig in Wirtszellen einzunisten. Sie haben herausgefunden, dass spezielle Enzyme es ihnen ermöglichen, die Ubiquitin-Markierung, die sie für die Zerstörung markieren, dauerhaft zu entfernen.

Mehr dazu ➡️ https://uni.koeln/SVNDW

#UniKöln #UniCologne #Bakterien #Ubiquitin #Forschung #Mikrobiologie

Moving averages on the switch, small bins statistics on the router? I like the blinkenlights. #StreamingMedia #Ubiquitin #HomeNetworking

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=83899

Post doc

Lund university

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82914

#hematopoiesis #leukemia #protein_degradation #ubiquitin #ScienceJobs #hiring #research
https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82914

Post doc

Lund university

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82907

#hematopoiesis #leukemia #protein_degradation #ubiquitin #ScienceJobs #hiring #research
https://jobrxiv.org/job/lund-university-27778-post-doc/?feed_id=82907

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=81143

How can the #ubiquitin #ligase APC/C recognize and inactivate the major kinase, CDK1-Cyclin B1, as soon as the spindle checkpoint is switched off?
Luca Cirillo, Rose Young et al identify chromosome as the key platform, recruiting both Cyclin B1 and APC3 via arginine anchor motifs in their sequences
Jon Pines, Claudio Alfieri and coworkers
https://www.embopress.org/doi/full/10.1038/s44318-024-00194-2

#Introduction

I am a biochemist/structural biology researcher and professor at the MRC PPU, University of Dundee. My research group studies #ubiquitin biology protein and #signalling mechanisms. I think my posts will mainly be #science, ubiquitin and signalling related.

Thanks to a very helpful guide from @quantixed.org, I can move away from Twitter, start exploring Mastodon and be part of scientific discussions

Postdoctoral Fellow in Cell Biology, Biochemistry or Proteomics (New York).

Sloan Kettering Institute

Come join us as a Postdoctoral Fellow to study #Ubiquitin, #Autophagy, #Biochemistry, and #Proteomics at the Sloan Kettering Institute in New York.

See the full job description on jobRxiv: https://jobrxiv.org/job/sloan-kettering-institute-27778-pos...
https://jobrxiv.org/job/sloan-kettering-institute-27778-postdoctoral-fellow-in-cell-biology-biochemistry-or-proteomics-new-york/?feed_id=79736

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability

#Cancer #research: New Collaborative Research Centre #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE investigates the role of the protein #Ubiquitin in cancer. Funded with 18 million euros @dfg_public
https://nachrichten.idw-online.de/2024/05/31/new-collaborative-research-centre-seeks-innovative-therapies-against-cancer

#Cancer #research: New Collaborative Research Centre #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE investigates the role of the protein #Ubiquitin in cancer. Funded with 18 million euros @dfg_public
https://nachrichten.idw-online.de/2024/05/31/new-collaborative-research-centre-seeks-innovative-therapies-against-cancer

Krebsforschung: Neuer Sonderforschungsbereich #UbiQancer @TU_Muenchen @goetheuni @Uni_WUE erforscht die Rolle des Proteins #Ubiquitin bei Krebserkrankungen. Gefördert mit 18 Mio Euro @dfg_public
https://nachrichten.idw-online.de/2024/05/31/neuer-sonderforschungsbereich-sucht-innovative-therapien-gegen-krebs

Targeted protein degradation #PROTAC is a promising avenue for drug development. This study shows that alkenyl oxindole compounds act as novel #E3ligase ligands & recruit the CRL4-DCAF11 E3 #ubiquitin ligase complex for substrate degradation #PLOSBiology https://plos.io/3WV1U9q

How does E3 #ubiquitin ligase RFDW3 regulate #ReplicationFork progression & stability? This study reveals that RFWD3 ubiquitylates SMARCAL1, disengaging it from RPA, limiting its activity at stalled forks & preventing fork collapse #PLOSBiology https://plos.io/3TsE6q5

PEX5 transports new proteins from cytosol to #peroxisome, where it is reversibly mono-Ub'ed at Cys11 for return to the #cytosol; longer #ubiquitin chains attached to Cys11 are rapidly removed by the enzyme E2D3, ensuring correct function #PLOSBiology https://plos.io/4a9gWf4