#WikIPathways

2026-02-25

Important: WikiPathways Technical Transition - Action Required for Some Users

Dear WikiPathways Community,

Effective April 1st, 2026, we will begin taking major steps toward retiring the classic WikiPathways backend as we complete our migration to our GitHub-based infrastructure.

1/

#wikipathways #biology #openscience

Egon Willighagenegonw@social.edu.nl
2026-02-22

new blog post: "Where do the WikiPathways come from?" chem-bla-ics.linkedchemistry.i doi.org/10.59350/6smn2-ah530

"We can see who the 8 people are who contributed to this pathway [..], and many authors are member of the @wikipathways review team who focus more on technical quality and the biology. The first author, however, often is the person who contributed most of the biological knowledge in the pathway"

Replies to this post show up in the blog.

#wikipathways #biology #provenance

Screenshot from the blog post, showing the WikiPathways SPARQL interface with a SPARQL query in the text box in the top left, on the right hand side a folder structure with other examples SPARQL queries, and in the bottom a table with results from the text box SPARQL query. The table shows a list of eight authors of the pathways with identifier WP10. It shows their names, there profile pages, and for some of them, their ORCID identifiers.
Marvin MartensMarvin@social.edu.nl
2026-02-21

WikiPathways RDF IRIs are now dereferenceable! Every rdf.wikipathways.org/ identifier now resolves via HTTP with content negotiation: HTML for browsers, Turtle/JSON-LD/RDF-XML/N-Triples for machines.

Try it: click any IRI on the about page, or curl one with an Accept header.

rdf.wikipathways.org/about
github.com/wikipathways/wikipa

#LinkedData #FAIR #WikiPathways #RDF #Bioinformatics #SemanticWeb

Egon Willighagenegonw@social.edu.nl
2026-01-21

hi, if you are using the #WikiPathways (@wikipathways) RDF, please send me a ping. In the coming months, changes are going to happen. To fix and improve some old designs, to add new functionality (like in the January release with more direct IRI links to other knowledge graphs).

Some things may break. And I want to know your use case. I like to get a shortlist of people who I want to give a heads-up and possible even consult on changes in the design and shapes

2026-01-06

"QPX: Pathway analysis environment" doi.org/10.37044/osf.io/m37f2_

"Building on our work at DBCLS BioHackathon 2023 (BH23), where we introduced QPX and promoted pathway modeling with WikiPathways (Pico et al., 2008) using PathVisio (Kutmon etal., 2015), we now focused on creating new pathway diagrams for diverse species and registering them in WikiPathways with functional annotations. In parallel, we deployed WikiPathways node data into Elasticsearch to enable fast and flexible search and integration of pathway information." osf.io/m37f2_v1

#biohackathon #BH25JP #wikipathways

Screenshot of the linked BioHackrXiv preprint, showing the top half of a preprint PDF page, showing the BioHackrXiv logo from the template, a table at the top listing a Arabidopsis thaliana pathway, and below that part of Figure 1 showing a "[p]athway diagram for for Caffeine synthesis inCoffea arabica.  This diagram is already published in WikiPathways at https://www.wikipathways.org/pathways/WP5586.html".
Egon Willighagenegonw@social.edu.nl
2026-01-06

@jerven I had not answered your question yet, and no patch needed, but just to answer it:

1. the original (theseus) code is here: github.com/wikipathways/GPML2R which is used for sparql.wikipathways.org/

2. the new libGPML-based code is here: github.com/egonw/org.pathvisio which is used for plantmetwiki.bioinformatics.nl/

#plants #sparql #wikipathways

Egon Willigh☮gen 🟥egonw
2025-09-07
Screenshot of a section of the linked page, the metadata column on the right hand side, showing the Keywords panel (with Bioinformatics and WikiPathways), the Programming languages as horizontal bar plot (mostly HTML (95%) despite it being an R (5%) package), License (MIT), Source code (Codeberg), and Packages (BioConductor). The last two are with their logos.
Egon Willighagenegonw@social.edu.nl
2025-06-29

reflecting on my @biocurator Advanced Career Award nomination: "Curation is an essential part of doing research" chem-bla-ics.linkedchemistry.i

replies to this post become blog comments.

#biocuration #wikidata #wikipathways #citoOntology

The number of articles talking about biocuration is growing every year, as visible in this Scholia histogram showing the number of (mostly) journal articles per year.
Egon Willighagenegonw@social.edu.nl
2024-12-20

curation is continuing, and if you really want to see what we do, check this feed of #WikiPathways edits: classic.wikipathways.org/index

I am looking into various simpler fixes from this page: wikipathways.org/sr24-curation

Donations are still welcome! We are only at 820 euro now (the full SR24 is at 2.9 million euro for research into inherited metabolic disorders). Help us, help MetaKids, help the kids with metabolic disorders. npo3fm.nl/kominactie/acties/wi

#sr24 #metakids

Screenshot that I shared multiple times now, now saying we raised 820 of 1250 euro.
Egon Willigh☮gen 🟥egonw
2024-12-19

this is the fourth day of the Serious Request fundraising for of our action. The DJs locked themselves up in the glass house in the Overijssel city Zwolle yesterday afternoon, the our @wikipathways now raised 730 euro :)

Highlights yesterday include:

- mastodon.social/@egonw/1136749
- mastodon.social/@egonw/1136743

Today we have the "WikiPathways in actie voor MetaKids" community day, and now heading to University!

Egon Willigh☮gen 🟥egonw
2024-11-14

@egonw@social.edu.nl een tweede update. om het makkelijker te maken om prioriteiten te stellen, zijn de curatie testen nu niet meer rood of groen, maar ook geel en oranje, afhankelijk van hoeveel er aan het pathway te verbeteren valt :)

Egon Willighagenegonw@social.edu.nl
2024-11-08

een eerste update. De eerste donaties zijn binnen (dank!).

De planning gaat goed door. Er is een extra persoon aangesloten, de websites zijn wat bijgewerkt, er is een lijst gemaakt met pathways uit een standaardwerk die we kunnen toevoegen, en ik heb de data curatie pijplijn opgezet: wikipathways.org/sr24-curation (die ook de pathways in #SBML vertaalt)

#WikiPathways #SR24

Screenshot van een data curatie pagina die laat zien dat dit pathway verbeterd kan worden door meer literatuurreferenties toe te voegen aan individuele stappen van de biologische processen.
2024-11-01

COVID-19 biological pathways from WikiPathways project

wikipathways.org/communities/c

#COVID #CoV #WikiPathways

COVID-19 adverse outcome pathway (WP4891).  Complex diagram showing biological pathways in many blocks.
2024-10-31

Post-COVID neuroinflammation (WP5485)

This is a WikiPathways biological pathways diagram. This pathway visualizes the direct and indirect route of SARS-CoV-2-mediated neuroinflammation, which may induce dysautonomia, a major post-COVID symptom. The direct and indirect route are subdivided in a neurological and hematological, and a neurological and humoral route, respectively.

wikipathways.org/pathways/WP54

#LongCOVID #WikiPathways #neuroinflammation #COVID

Biological pathway diagram of direct routes of neuroinflammation from COVID via neuronal route and a hematological route.
Egon Willighagenegonw@social.edu.nl
2024-08-07

new blog post: "CiTO updates: Wakefield and WikiPathways" chem-bla-ics.linkedchemistry.i

replies to this post become blog comments.

#wikipathways #CiTO #wikidata

Screenshot of GitHub showing the source YAML of the file listing which articles cite specific WikiPathways. We see four WP identifiers, each with one ore more citations to them, each with an PubMedCentral identifier, the article title, and the year in which it was published.  For example, WP10 was cited by a 2022 article with identifier PMC8917653 with the title "Transscriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes".
Egon Willighagenegonw@social.edu.nl
2024-07-13

your ideas about biological processes can be made FAIR in databases like @wikipathways and @reactome

People are using these pathways in their analyses of biological data, and some of those journal articles cite the specific pathways. #WikiPathways makes a reasonable attempt (particularly given the minimal funding) at tracking that.

I just added another three articles, citing some ~20~ish pathways

For example, wikipathways.org/instance/WP16 has been cited at least 4 times

Screenshot of GitHub showing three commits by me in the past hour with undescriptive commit messages "A(dded a)nother article".Screenshot of the https://github.com/wikipathways/wikipathways-database/blob/main/downstream/citedin_lookup.yml file where we collect the citations (almost 1300 now) for WP1601Screenshot of the online WikiPathways page for WP1601 (https://www.wikipathways.org/pathways/WP1601) showing the five papers that cite WP1601 (that we know of)
BiGCaT Bioinformaticsbigcat_UM@social.edu.nl
2024-06-17

next week, Denise Slenter will defend her PhD thesis, and in the morning we are organizing a mini symposium With @schymane, @susancoort, Justin van der Hooft, Rachel Cavill, and Laura Steinbusch

If you want to join, you can register here: forms.gle/MsfrRomsiHSk2JPAA #metabolomics #wikipathways #chemistry

Mini Sympoium info poster:

Symphonies of Metabolomics - 
Utilizing graphs as sheet music to orchestrate biochemical interactions relevant in health and disease

09:00 - 09:10      Registration and coffee
09:10 - 09:30	Dr Egon Willighagen, Maastricht University
09:30 - 10:00	Prof. dr Emma Schymanski
Environmental Cheminformatics and Metabolomics – Two Worlds Collide?
10:00 - 10:20	Dr Laura Steinbusch
10:20 - 10:40	tba

10:40 - 11:00	Break
11:00 - 11:20 	Dr Justin van der Hooft, Wageningen University
On the art of conducting mass spectral grouping to extract meaning from metabolomics profiles
11:20 - 11:40	Dr Rachel Cavill
Using multivariate models to find the metabolic harmony in multi-omics datasets
11:40 - 12:00	Dr Susan Coort
	Metabolomics in Nutrigenomics: A Path to Personalized Nutrition
12:00 - 12:20	tba

12:20 - 12:30      Close
Egon Willighagenegonw@social.edu.nl
2024-02-11

obligatory screenshot, and it's fast indeed #QLever #WikiPathways

WikiPathways RDF loaded into a local #QLever triple store with in the screenshot of the QLever UI with a SPARQL query that counts the number of metabolites in pathways by species, with 5899 unique metabolite identifiers for Homo sapiens, and 10 more metabolite counts for other species. All in 44ms.
Egon Willighagenegonw@social.edu.nl
2024-01-28

new preprint: "Community curation of kinetic data to support metabolic models through semantic web technology" doi.org/10.5281/zenodo.1041871 #wikipathways #rdf #disorders

Egon Willighagenegonw@social.edu.nl
2024-01-18

De inschrijving voor het VHP4Safety mini-symposium rondom de promotie van Marvin Martens op 29 januari is geopend! lnkd.in/dmgHTbUH (Beperkt aantal plaatsen) Met sprekers: Chris Evelo (Marvin's promotor), Holly Mortensen, Anne Kienhuis, Joost Beltman en Mathieu Vinken. #VHP4Safety #AOPWiki #wikipathways

@Marvin's PhD thesis is the result of work in the #OpenRiskNet and #EUToxRisk projects

Information leaflet about the mini-symposium, with date (29 Jan), venue (Maastricht University), the registration link, and the program, the last two in the main post.

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