Abschied von Porec und 2 Tage nach Triest

Nach einem wieder sehr guten Frühstück, im Monte Rosso, geht es wieder retour nach Trieste.

Wir wählen diesmal die Straßenroute und versuche am Meer entlang zufahren. Gleich vorweg, das gelingt nicht ganz gut, oft stehen wir oder müssen umdrehen, da wir uns verfahren. Navi haben wir zwar, aber mit dem Rad funktioniert es nicht ganz gut. Die ersten Kilometer geht es, es gibt einen […]

https://www.brigitteundrolandunterwegs.com/b/7w3

#AlpeAdriaRadweg #Antenal #Apartment #Arnoldstein #BarTropicana #Dalja #Fahrradgepäck #Fähre #Genusstour #Grenzübertritt #Hafen #Izola #Koper #Leibnitz #Mirna #Monterol #Muggia #Novigrad #Ortlieb #Porec #Portorož #RadlDilemma #Radweg #Salinen #slowenien #Straßenroute #trieste #Umag #Valica #Vižinada #Zugfahrt

Circular RNAs derived from MIR156D promote rice heading by repressing transcription elongation of pri-miR156d through R-loop formation.

#RNA #miRNA #circRNA #Rloop #Oryza_sativa #PlantScience

https://www.nature.com/articles/s41477-025-01961-7

TLDR: Pandas are dope fiends!?

TIL that 🐼 Pandas aren't born loving 🎍bamboo, but that it's an addiction with a dopamine component.

Those cute furry pandas are actually carnivores. 🍖

But they sit on their butts all day eating plants 🌿 and getting 🌀👃🌀 high instead of chasing animals. 🐁

Quote: "some of the bamboo-derived miRNAs were found to regulate dopamine pathways, driving food motivation and the reward system linked to it. So if eating bamboo is a pleasurable, satisfying experience for a panda, it's more likely to be solely driven to seek out this trigger." https://newatlas.com/biology/pandas-bamboo-micro-rna/

Pandas! :pandahype: :pandabighype:

#drugs #dopamine #pandas #bamboo #miRNA #RNA

Why don't #pandas eat more meat? #Molecules found in #bamboo may be behind their plant-based diet.

#miRNA #regulation #gene_expression #sensing #dopamine

https://phys.org/news/2025-02-dont-pandas-meat-molecules-bamboo.html

The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers
https://www.science.org/doi/10.1126/sciadv.ado2830
pdf: https://www.science.org/doi/epdf/10.1126/sciadv.ado2830

* diverse regulatory roles in cancer

#cancer #genetics #genomics #FunctionalGenomics #NoncodingDNA #ncDNA #miRNA #GeneRegulation #CRISPR

To achieve this, we developed #DynamiR (https://codeberg.org/a_probst/DynamiR).

DynamiR a Python-based open-source tool with minimal dependencies, making it easy for anyone to analyze independently.

It's built on open data and decentralized, ensuring flexibility and adaptability.

#miRNA #NeurodegenerativeDiseases #ResearchUpdates #OpenScience #SoftwareDevelopment #PD #ALS #HD

research article [2019]

Pollen-derived RNAs Are Found in the Human Circulation
https://doi.org/10.1016/j.isci.2019.08.035

#pollen #microRNA #miRNA #bioavailability #platelets #Lungs #biology

Cancer vaccines show promise
https://www.economist.com/science-and-technology/2025/01/01/cancer-vaccines-are-showing-promise-at-last
non-paywalled: https://archive.fo/ncAYX

Comment: revolutionary

* trials: skin, brain, lung tumors
* possible w/i 6 wk due to mRNA vaccines

https://en.wikipedia.org/wiki/MRNA_vaccine
* uses fragment (cloned copy) of messenger RNA (mRNA)
* injected; stimulates adaptive immune response
* body identifies/destroys corresponding pathogen (SARS-Cov-2: COVID-19 ...) or cancer cells

#cancer #cancervaccines #vaccines #mRNA #mRNAvaccines #immunity #ImmunoTherapy #miRNA

Andrew M. Lewis, Jr & Gladys S. Lewis on #PLOSONE October 24, 2022

The AGMK1-9T7 cell model of #neoplasia: Evolution of #DNA copy-number aberrations and #miRNA expression during transition from normal to #metastatic #cancer cells

https://dx.plos.org/10.1371/journal.pone.0275394

#biomarker #oncology #tumorigenicity #cancercells

E anche oggi abbiamo certificato l'ignoranza dei no-vax, gruppo di dementi molto nutrito e anche molto rumoroso in Italia.
Perché dico questo? Perché alla notizia della vittoria del Nobel per la medicina da parte di Victor Ambros e Gary Ruvkun per il loro lavoro sul microRNA, i no-vax hanno iniziato a parlare lobby, vaccini per covid , BigPharma etc senza sapere che il microRNA è un acido nucleico diverso dal mRNa

#miRNA #mRNA #AcidoNucleico #biologia #nobelmedicina2024

https://www.lescienze.it/news/2024/10/07/news/nobel_medicina_fisiologia_2024-17354060/

Ich hab heute Spätschicht für euch gemacht, um (hoffentlich) schön aufzuschreiben, wie es zur Entdeckung von #miRNA kam und was hinter dem diesjährigen Med/Physio-#Nobelpreis steckt: #Wissen #Wissenschaft
https://www.spektrum.de/news/nobelpreis-fuer-physiologie-oder-medizin-2024-micrornas/2236046

2024 Nobel Prize in Medicine for discovery of "microRNA and new Principle of Gene regulation"
The 2024 Nobel Prize in Physiology or Medicine has been awarded jointly to Victor Ambros and Gary Ruvkun “for the discovery of microRNA and its role...........
#GaryRuvkun #generegulation #microRNA #miRNA #Nobelprize #NobelprizeinMedicine #RNA #transcription #VictorAmbros
Rajeev Soni

https://www.scientificeuropean.co.uk/sciences/biology/2024-nobel-prize-in-medicine-for-discovery-of-microrna/

2024 Nobel Prize - Chemistry
https://www.nobelprize.org/prizes/medicine/2024/press-release

Nobel Prize in Medicine goes to U.S. biologists who discovered microRNA
https://www.cbc.ca/news/world/nobel-medicine-prize-1.7342982?cmp=rss
Victor Ambros, Gary Ruvkun

Medicine Nobel awarded for gene-regulating microRNAs
Victor Ambros and Gary Ruvkun identified a class of tiny molecules that have a crucial role in controlling gene expression
https://www.nature.com/articles/d41586-024-03212-9

#2024Nobel #NobelPrize #chemistry #miRNA #microRNA

Partially or completely blocking this second process: translation in #Ribosomes is called #Ribointerference and is caused by a group called interfering RNA.
One of these is #miRNA -micro RNA-
Eukaryotic cells possibly inherited this mechanism and in most cases it has been conserved.
This has to do with something that is possibly a principle of #Physics called conservation of information.

Today #Nobel Assembly of #Karolinska Institutet has recognized the work of 71 yo Victor Ambros and 72 yo Gary Ruvkun aimed at proving existence of #miRNA
-micro RNA- and its importance in🧬#Gene regulation
with 2024 #NobelPrize in #Physiology or #Medicine
Something about this follows

Role of #miRNA in Highly Pathogenic #H5 Avian #Influenza Virus #Infection: An Emphasis on Cellular and #Chicken #Models, Viruses: https://www.mdpi.com/1999-4915/16/7/1102

Current research indicates that miRNAs play a significant role in HPAI H5 infections, influencing various aspects of the disease process. This review aims to synthesize recent findings on the impact of different miRNAs on immune function, viral cytopathogenicity, and respiratory viral replication.

| Dermatology Reports |

Teenage #acne is a frequent inflammatory skin disease, with face-specific lesions, papules, pustules, and nodules, caused by complex interactions between the pilosebaceous unit and C. acnes bacterium. In recent years, nucleic acid therapies (NATs) such as short-interfering RNA drugs for rare disorders have been approved at a much higher rate.
Clinical research for skin microRNA (#miRNA) regulation and NATs may treat acne in the future

➡️ https://doi.org/10.4081/dr.2024.9902

Things aren’t always what they seem! Three #preprints together reveal that the lncRNA ivory and its microRNA mir-193, not cortex, drive melanic scale identity in butterflies 🦋

Brilliant preLight from Isabella Cisneros! 🤩

#preLight 👉 https://prelights.biologists.com/highlights/a-long-non-coding-rna-at-the-cortex-locus-controls-adaptive-colouration-in-butterflies-the-ivory-lncrna-regulates-seasonal-color-patterns-in-buckeye-butterflies-a-micro-rna-drives-a-100-million-year-2/

#biology #butterfly #color #patterning #lncrna #mirna #rna

Improving #plant health diagnostics: The dawn of #microfluidic devices for rapid #miRNA detection.

#miR399 #phosphate #nutrition

https://phys.org/news/2024-03-health-diagnostics-dawn-microfluidic-devices.html