Using a forebrain assembloid model, Kim & team unveil that gene-regulating crosstalk between neurons & glial cells potentially contributes to developing schizophrenia. #preprint
#preLight prepared by Justine Gromaire, Aimee Xinxo & Jeremie Van Prooijen ⬇️ 👀 #uMontreal
Who “belongs” in biology?
The first comprehensive analysis of the LGBTQ+ climate in the biological sciences! #LGBTinSTEM #preprint 🏳️🌈
#preLight prepared by Ryan, Stefan & Reinier ⬇️ 👀
https://prelights.biologists.com/highlights/lgbtq-realities-in-the-biological-sciences/
#belonging #biology #community #inclusivity #LGBTQIA #survey
Swirl, align, invade!
Collective motion of cancer cells radially aligns collagen fibers and promotes invasion. #preprint Aashrith Saraswathibhatla et al. #theChaudhurilab
Check out the latest #preLight from Sharvari Pitke ⬇️ 👀
‘These cracks, they let the developing cells in: A chronicle of trabeculation in the developing zebrafish heart’ 🎵
Theodora Stougiannou highlights recent work from Christopher Chan Jin Jie, Rashmi Priya & team. #preprint
Check out the #preLight ⬇️ 👀
https://prelights.biologists.com/highlights/mechanical-fracturing-of-the-extracellular-matrix-patterns-the-vertebrate-heart/
A new study from Washington State University explores the transgenerational impact of prenatal cannabis exposure in mice. #preprint
#preLight prepared by Behiye Sanliturk, Ali Gharbienne & Solal Aubailly ⬇️ 👀 #uMontreal
We can make decisions in our sleep! This #preprint reveals how the different sleep stages alter the underlying mechanisms of decision-making.
#preLight prepared by Joseph Lefèvre López & Nghi Vuong Nguyen ⬇️ 👀 #uMontreal
First preLights post from Jenny Singh!
She covers work showing that Lamin A/C maintains replication fork integrity during mild replication stress by modulating chromatin structure and restraining RECQ1 activity. #preprint
#preLight ⬇️👀
https://prelights.biologists.com/highlights/nucleoplasmic-lamin-a-c-controls-replication-fork-restart-upon-stress-by-modulating-local-h3k9me3-and-adp-ribosylation-levels/
So many features…so little time: bumblebees show optimization of cue integration in a memory task. 🐝🐝
Really entertaining #preLight prepared by Tim Schwanitz & Cemre Coskun in which they highlight recent work from Anna Stöckl & team ⬇️ 👀
Why do preterm neonates struggle to control sepsis?
“This study provides insight into how Krüppel-like factor 2 (KLF2) is involved” and shows that “KLF2 is a promising target in successfully treating newborns with sepsis.”
#preLight from Sydney Call & Sahan Senanayaka #ImmunobiologyUA ! ⬇️ 👀
#immunology #sepsis #biology #therapeutics #endotoxemia #inflammasome
Not all aspartate limitation is created equal.
An aspartate biosensor reveals that inhibiting succinate dehydrogenase results in defects in pyrimidine synthesis and replication stress, unique from other methods of aspartate limitation.
First #preLight from Hannah Pletcher ⬇️ 👀
https://prelights.biologists.com/highlights/succinate-dehydrogenase-loss-causes-cascading-metabolic-effects-that-impair-pyrimidine-biosynthesis/
Blurring the lines between retrotransposons & viruses!
sORF2 enables envelope-independent, direct cell-to-cell transmission of retrotransposons in Drosophila, challenging our understanding of mobile genetic elements.
#preLight from Ally Simpson & Alyss Humphrey #ImmunobiologyUA ! ⬇️ 👀
👉 https://prelights.biologists.com/highlights/direct-cell-to-cell-transmission-of-retrotransposons/
#genetics #immunobiology #drosophila #retrotransposons #TEs #viruses
Macrophages sense and adapt. Immuno-mechanics meets cancer research.
Roberto Amadio highlights recent work from Wenyan Xie and colleagues.
Roberto: “The huge amount of data (…) is of high value not only to cancer biologists, but also to cell biologists and clinicians”.
#preLight ⬇️ 👀
#biology #biomechanics #immunosuppression #macrophages #cancer #pyk2
Seeing stars ✨
Astrocytes in primary visual cortex drive migraine pain.
Check out the new preLights post from Vanessa Ehlers highlighting a recent study from Dara Bree, Dan Levy & team. #preprint
#preLight ⬇️ 👀
👉 https://prelights.biologists.com/highlights/cortical-astrocyte-activation-triggers-meningeal-nociception-and-migraine-like-pain/
Defence mechanism inception!
Listeria prophages protect their host bacteria with anti-phage systems, leaving them susceptible to their own defence systems - read how this may actually be an evolutionary advantage!
#preLight from Briana Guzman, Noah Franz #ImmunobiologyUA ! ⬇️ 👀
#microbiology #immunobiology #bacteria #infection #phages #prophages
ISR alone won’t cut it: stalled ribosomes block stress granule formation despite ISR activation.
Mohammed Jalloh highlights a #preprint from the Moon lab.
#preLight ⬇️ 👀
👉 https://prelights.biologists.com/highlights/trna-synthetase-activity-is-required-for-stress-granule-and-p-body-assembly/
#biology #stress #StressGranules #translation #biochemistry #ribosomes
Led by Samuel Campos, the IMB565 class #ImmunobiologyUA has preLighted recent #immunology preprints.
“Resident Killers: Tonsil resident NK cells show potential against early HIV-1 infection.” #preprint from David Perea, Maria Buzon & team
#preLight prepared by Sukirti Shivpuri, Jared Alvarez & Vanessa Brizuela ⬇️
New #preLights post from Vibha Singh! 👀
In this highlighted #preprint, the research team (#NalbantLab) introduces a powerful new approach to studying mechanobiological regulation in cancer. In doing so, they describe how tumour cells manage to “pull” themselves away from the tumour bulk during invasion.
Read the #preLight here 👉 https://prelights.biologists.com/highlights/optogenetic-stimulation-of-lbc-gef-mediated-rho-activity-dynamics-promotes-cell-invasion/
#CancerResearch #Optogenetics #Mechanobiology #TumourInvasion
