I spent a few days earlier this year in rural Washington state and St. Louis, Missouri, for a New York Times story on Doug Whitney, a man who should have died two decades ago from early-onset Alzheimer's Disease, but somehow hasn't developed any symptoms. His mother was one of 10 siblings, out of 13, in her family who died from the disease; the family carries a genetic mutation that makes them more likely to develop early-onset Alzheimer's. Doug, now in his mid-70s, is the only known person in the world to have the mutation and not have symptoms of the disease, which usually present before one reaches mid-50s. Since discovering his genetic predisposition to the disease, he has been studied by researchers at Washington University in St. Louis, allowing doctors to poke, prod, scan, and do everything they need to figure out why he hasn't developed Alzheimer's. At his home, he sat with wife Ione and worked on jigsaw puzzles while I visited. In St. Louis, he underwent MRI and PET
scans, a spinal tap, blood draws, and other mental and physical examinations that he has been doing annually so the researchers can add to their long-term record of his genetics, physiological characteristics, and mental capabilities as he ages. One particular avenue of recent investigation is a significant build-up of heat-stress proteins in his brain possibly from his years working as a Navy mechanic, which some believe may make Doug less susceptible to the development of tau tangles in the brain, a hallmark of Alzheimer's disease. It was great to work so closely with Pulitzer-winning reporter Pam Belluck on this, whose health reporting I've sought out over the years.
A big thanks to Matt for the call on this assignment and for big play in the paper and online (with some video!)
#photography #photojournalism #news #health #science #onassignment #alzheimersdisease
























