Molecular basis for anti-jumbo phage #immunity by AVAST type 5.
Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.
https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology
#otd #startrek #voyager #Phage #janeway #chakotay #tuvok #kim #paris #belannatorres #kes #emh #neelix #dereth #motura #seska #Vidiians #startrek59 @trekcore
"The very discovery of phage was the subject of a prolonged dispute between two camps: on one side was Félix d’Herelle,Citation5 the French-Canadian autodidact who first recognize ..."
A pleasure to have @mfwhite2.bsky.social for our first #BiosciencesInstitute seminar this year and hearing all about #bacterial #phage defences
#AI can now design functional #viruses - not the computer kind, either
Inject this synthetic #phage into #Ecoli and it kills better than the real thing
#Bacteriophages, are viruses that infect bacteria, have been widely studied since their discovery in the early 20th century. The end result of the AI portion of the project was a pool of 302 candidate #genomes, 285 of which were able to generate full genomes. Of those, 16 were found to inhibit growth of E. coli #bacteria.
https://www.theregister.com/2025/09/18/researchers_just_created_a_working/
1/5
Today I finished reading the non-fiction book The Good Virus, by Tom Ireland. Picked it up somewhat at random since I don't usually read non-fiction, and I'm not usually into biology.
But it turned out to be an excellent book, perhaps the best book I've read this year.
https://www.amazon.com/Good-Virus-Amazing-Forgotten-Promise-ebook/dp/B0BHPRSWFT/
"Entelli-02 exhibits 88% host coverage against The Alfred Hospital’s ECC isolate collection (n = 206), confirmed by plaque formation and reduced bacterial load in septicaemic mice by >99%. We produced this cocktail as a therapeutic-grade product, ready for clinical use. Entelli-02 represents a hospital-specific phage cocktail with frontline efficacy and on-demand availability."
I'm having a blast testing out Phold from @GB13Faithless - new preprint available here:
https://www.biorxiv.org/content/10.1101/2025.08.05.668817v1
Protein language model & structural alignment aided annotation. It immediately picked out some interesting replication genes from a prophage region I've been wrecking my head over for a while now.
https://github.com/gbouras13/phold
Worth checking out!
Interesting.
BBC News: I found a bacteria-eating #virus in my loo - could it save your life?
@Vampykitten
Controversial episode. Weirdly, the show never tells us what #Neelix and #Tuvok thought of the decision, or what they remember (if anything) of #Tuvix.
Janeway is faced with a somewhat similar decision in the earlier #Phage, where the Vidiian who stole Neelix's lungs can't return the lungs because they have already been genetically modified, and it would kill the Vidiian. In this case she says rather forcefully that her ethics prevent her from killing someone.
Interesting show.🤔
That's a helluva ethical conundrum #Janeway was in after capturing the Vidians, and I can't believe she decided to release them with a warning. (At least she did it while yelling at them!)
I also can't believe she let disease ravaged terminally ill aliens wonder about the ship without containment. #StarTrek sometimes makes zero sense. 🤦♂️
Damn, the Vidians had been dealing with the Phage for 2 millenia until they suddenly met the #ThinkTank, wow. 😬
I don't think I've ever seen this episode before. 🤔🙂
Between the medical scene in #Caretaker, and these Vidians, I forgot how gross early #StarTrekVoyager could be. 🤢
A fan poster for tomorrow night's Star Trek: Voyager episode #Phage on H&I All Star Trek.
https://www.handitv.com/allstartrek
Artist: James Robert Rye
Source: https://www.trekbbs.com/threads/voyager-episode-posters.308580/
#StarTrek #StarTrekPoster #AllStarTrek #StarTrekVoyager #JamesRobertRye #StarTrekVoyagerPoster
A precursor procapsid is initially formed during #bacteriophage assembly, but how? The #cryoEM structure of the scaffolding protein complex & portal within #phage P22 procapsid reveals how this complex orchestrates the initiation of procapsid assembly @PLOSBiology https://plos.io/44B71iE
#UTISky meet team #phage
Compelling summary slide from #ESCMIDGlobal
#IDSky
RE: https://bsky.app/profile/did:plc:d5twxexrwk5fwdvyvlbvycgb/post/3lmkfnz4fi22g
PHORCE allows measurement of lytic #phage amplification rates in bacterial populations. This study uses PHORCE to reveal phenotypic diversity among #Ecoli & #Paeruginosa phages; phage- #antibiotic interactions are mainly determined by the drug @PLOSBiology https://plos.io/3G2myhf
