Lmst

Most genetic screens characterize host factors important for early stages of #viral #infection. This study uses a genome-scale #siRNA screen designed to uncover key pathways influencing early & late stages of #SARSCoV2 infection, including non-canonical NF-κB pathway @PLOSBiology https://plos.io/3ZX0fRe

Network integration reveals relevant networks implicated in SARS-CoV-2 replication. The network containing the identified proviral (green) and antiviral (red) human host factors was integrated with host factors reported to be relevant for SARS-CoV-2 infection. These include genetic CRISPR screen hits (dark pink), protein–protein interaction hits (blue, purple), as well as hits from a phosphoproteomics study (yellow). The network was subjected to supervised community detection, and then clustered based on identification by all datasets (top left), this screen and proteomics data but not CRISPR screens (bottom left), or exclusively by this screen (right). The top 10 GO categories with the lowest p-values are shown. Continuous black edges indicate interactions from STRING database, discontinued edges indicate virus-host interactions. Turquoise nodes indicate SARS-CoV-2 proteins. White denotes proteins in network (based on STRING) but not identified in any of the OMICs studies. Asterisk indicates highlighted clusters.

Qfitlia (Fitusiran): A Novel siRNA-based Treatment for Haemophilia
Qfitlia (Fitusiran), a novel siRNA-based treatment for haemophilia has received FDA approval............
#Bleedingdisorders #FDA #Fitusiran #Haemophilia #Hemophilia #Qfitlia #siRNA
Umesh Prasad

https://www.scientificeuropean.co.uk/medicine/qfitlia-fitusiran-a-novel-sirna-based-treatment-for-haemophilia/

Qfitlia (Fitusiran): A Novel siRNA-based Treatment for Haemophilia
Qfitlia (Fitusiran), a novel siRNA-based treatment for haemophilia has received FDA approval............
#Bleedingdisorders #FDA #Fitusiran #Haemophilia #Hemophilia #Qfitlia #siRNA
Umesh Prasad

https://www.scientificeuropean.co.uk/medicine/qfitlia-fitusiran-a-novel-sirna-based-treatment-for-haemophilia/

Protecting #crops: #RNA-based substances open up new avenue to combat a widespread #plant #virus.

#mosaic_virus #agriculture #food_security #aphids #vectors #siRNA #edsRNA

https://phys.org/news/2025-03-crops-rna-based-substances-avenue.html

Starting TOMORROW, 📅 Nov. 14, 2024, at 🕒 2:30 PM CET: "Computational approaches in improving spermine-based RNA #nanocarriers" with Olivia Merkel, Ludwig-Maximilians-Universität Munich, on 📅 Nov. 14, 2024 🕒 2:30–3:30 PM CET.

Register for FREE 🔗 https://www.beilstein-institut.de/en/talks/nanotechnology-computational-approaches-in-improving-spermine-based-rna-nanocarriers?M=y

#DrugDelivery #siRNA
#BeilsteinTalks

Join the online #BeilsteinTalk "Computational approaches in improving spermine-based RNA #nanocarriers" with Olivia Merkel, Ludwig-Maximilians-Universität Munich, on 📅 Nov. 14, 2024 🕒 2:30–3:30 PM CET.

Participation is FREE! Just register: 🔗 https://www.beilstein-institut.de/en/talks/nanotechnology-computational-approaches-in-improving-spermine-based-rna-nanocarriers?M=y

#DrugDelivery #siRNA
#BeilsteinTalks

Save the date: 📅 Nov. 14, 2024 🕒 2:30–3:30 pm CET

Online #BeilsteinTalk “Computational approaches in improving spermine-based RNA #nanocarriers" with Olivia Merkel, Ludwig-Maximilians-Universität Munich.

Register for FREE! 🔗 https://www.beilstein-institut.de/en/talks/nanotechnology-computational-approaches-in-improving-spermine-based-rna-nanocarriers?M=y

#DrugDelivery #siRNA
#BeilsteinTalks

Dall'Univaq una cura per l'osteoporosi autosomica. Brevettato all'Aquila farmaco contro malattia rara delle ossa. Dall'Università è stato dato in licenza a un'azienda britannica e ora è in attesa del via libera per la sperimentazione clinica negli Stati Uniti.

#malattierare #osteoporosi #osteoporosiautosomica #siRNA #SiSaf #UniAQ

https://scienzamagia.eu/scienza-tecnologia/dallunivaq-una-cura-per-losteoporosi-autosomica/

#Oligonucleotides are a relatively new( #novel ) class of #drugs that can modulate #gene expression through various mechanisms like #RNA interference, degradation, or splice-modulation.

This includes drugs like small interfering RNA (#siRNA), #microRNA (miRNA), and antisense oligonucleotides (ASOs).

https://ispe.org/pharmaceutical-engineering/november-december-2020/current-state-oligonucleotide-therapeutics

https://www.nature.com/articles/s41573-020-0075-7

Paper:

https://www.nature.com/articles/s41573-020-0075-7.pdf

Tulisan sains populer mengenai desain #siRNA untuk desain agen terapetik. Semoga bermanfaat! 🙏 https://generasipeneliti.id/tulisan.php?id=IDOk5y5bodI8ct&judul=Desain-in-silico-siRNA-dengan-Tools-Bioinformatika-untuk-keperluan-Terapetik #bioinformatika #biomedik #bioteknologi

Goldman Sachs closes $650M fund aimed at biotechs-- Boehringer bets $2B in biobucks to unlock siRNA targets for NASH treatments— FDA ends busy year with three drug rejections --http://bit.ly/w28kSd #goldmansachs #biobucks #sirna #nash #fda #funding #pharmanews #biotech #biopharma #biotechnology #cafepharma

Novo Nordisk says Wegovy can help heart disease patients—and not just because it produces weight loss-- 5 of the best paid biopharma CEOs --One dose of Lilly’s siRNA drug cuts Lp(a) for a year -- See more on our front page news http://bit.ly/w28kSd #novonordisk #wegovy #heartdisease #clinicaltrials #executivepay #pharmaceos #ceos #aha #elililly #sirna #pharma #pharmanews #biotech #biopharma #biotechnology #cafepharma

“Our research shows that #siRNA treatment can target the #virus in key regions that do not change as the virus evolves, which means it works across all current #variants of concern. Most importantly, we envisage that it will also work for existing and future #SARS #coronaviruses that emerge,”

“siRNA can stop #SARSCoV2 replication by directly targeting the virus itself, which means there is no immune system involvement,” https://med-mastodon.com/@LordsofHardwired/110874679883984122

We just put in a manuscript using #siRNA for knockdown. Knockdown verified with RT-PCR and Western blot. Saw a phenotype. Rescued it with ectopic expression of the knocked down protein. A reviewer required us to repeat the experiments using #CRISPR, and why we didn''t use crispr in the first place ?#thatsecondreviewer
#academia #cellbiology
A: Because we didn't need to, <expletive>.

Paper from our team about #siRNA and #COVID19. Already published last year, but maybe still relevant 😌🙂. A Computational Design of siRNA in SARS-CoV-2 Spike Glycoprotein Gene and Its Binding Capability toward mRNA https://journal.ugm.ac.id/ijc/article/view/68415/0