RNA pioneer Dr. Phillip Zamore joins TransCode Therapeutics' Scientific Advisory Board, bringing groundbreaking expertise in RNA interference and cancer research to advance innovative therapeutics #RNAi #Cancer
#RNAi
RNA research pioneer Dr. Phillip Zamore joins TransCode Therapeutics' Scientific Advisory Board, bringing breakthrough expertise in RNA interference and cancer therapeutics #RNAi #CancerResearch
RNA pioneer Dr. Phillip Zamore joins TransCode Therapeutics' Scientific Advisory Board, bringing groundbreaking expertise in RNA interference and cancer therapeutics research #RNAi #CancerResearch
#Pathogens like M. oryzae and the rice stripe #virus severely impact #crop yields, but #RNAi-based #rice #disease management may turn the tide in this battle. Here, Chen et al. explore the potential of sprayable sRNA and dsRNA molecules.
https://doi.org/10.1111/jipb.13896
@wileyplantsci
#PlantSci #CropSci #Phytopathology #JIPB
The cover of the May issue features a phoenix nanocarrier transporting RNAi "soldiers" who use their sharp spears to target and control #plant #pathogens, highlighting work on the potential of engineered nanotransporters for #RNAi delivery. https://www.jipb.net/EN/1672-9072/current.shtml
#PlantScience #Phytopathology #botany
#RNA interference is an important tool to protect #plants from #pathogens and pests, but delivery can be problematic. In this #JIPB review, Xing et al. explore the potential of engineered #nanotransporters for RNAi delivery.
https://doi.org/10.1111/jipb.13887
@wileyplantsci
#PlantSci #RNAi #Nanotech #botany
RNA:DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?
#HostPathogenInteraction #RNA:DNAtriplex #RNAi #Epigenetics
The perfect pesticide?
https://www.science.org/content/article/perfect-pesticide-rna-kills-crop-destroying-beetles-unprecedented-accuracy #environment #pesticide #RNAi #VarroaMite
Traditionally, vaccines contain either a dead or modified, live version of a virus. The body’s immune system recognizes a protein in the virus and mounts an immune response.
This response produces T-cells that attack the virus and stop it from spreading.
It also produces “memory” B-cells that train your immune system to protect you from future attacks.
The new vaccine also uses a live, modified version of a virus.
However, it does not rely on the vaccinated body having this traditional immune response or immune active proteins
— which is the reason it can be used by babies whose immune systems are underdeveloped, or people suffering from a disease that overtaxes their immune system.
Instead, this relies on small, silencing RNA molecules.
“A host — a person, a mouse, anyone infected— will produce small "interfering RNAs" as an immune response to viral infection.
These #RNAi then knock down the virus,” said Shouwei Ding, distinguished professor of microbiology at UCR, and lead paper author.
The reason viruses successfully cause disease is because they produce proteins that block a host’s RNAi response.
👉“If we make a mutant virus that cannot produce the protein to suppress our RNAi, we can weaken the virus.
It can replicate to some level, but then loses the battle to the host RNAi response,” Ding said.
“A virus weakened in this way can be used as a vaccine for boosting our RNAi immune system.”
When the researchers tested this strategy with a mouse virus called Nodamura, they did it with mutant mice lacking T and B cells.
With one vaccine injection, they found the mice were protected from a lethal dose of the unmodified virus for at least 90 days.
Note that some studies show nine mouse days are roughly equivalent to one human year.
There are few vaccines suitable for use in babies younger than six months old.
However, even newborn mice produce small RNAi molecules, which is why the vaccine protected them as well.
UC Riverside has now been issued a US patent on this RNAi vaccine technology
https://scitechdaily.com/no-more-endless-boosters-scientists-develop-one-for-all-virus-vaccine/
Natural tech for 'dimming' #genes brings transformative potential to #agriculture.
https://phys.org/news/2024-03-natural-tech-dimming-genes-potential.html
J&J to acquire ADC drug developer Ambrx for $2B-- Merck inks $680M Harpoon buyout, spearing challenger to Amgen T-cell engager— Novartis dances into JPM with $250M Calypso buyout, $185M RNAi alliance --http://bit.ly/w28kSd #jnj #adc #merck #novartis #jpmhc24 #rnai #pharma #pharmanews #biotech #biopharma #biotechnology #cafepharma
The accepted (before proof) version of our first #2024 #article is available online:
The #Dicer-like Protein 4 and RNA-dependent RNA Polymerase 6 are Involved in Tomato Torrado #Virus Pathogenesis in #Nicotiana benthamiana
Published in #Plant and #Cell #Physiology and funded by #NCN #Sonata
#science #plantscience #plantvirus #virology #plantvirusinteraction #PTGS #RNAi #torradovirus
Targeted pest control with #RNA spray.
Bees, like all other organisms, have a lot of parasites. And it is likely that these are the main contributors to issues like colony collapse disorder (CCD).
UT Austin scientists have targeted one such deadly fungal parasite, Nosema ceranae, and have genetically modified a bacteria commonly found in bee guts to produce an RNA interference system preventing the fungus from making spores.
#Bees #Bacteria #Fungi #Biology #Biotech #Biotechnology #RNAi #Science #Scicomm
As part of our 20th anniversary, @Psarkies looks back at a classic #PLOSBiology paper that provided an early glimpse of the complexity of #RNAi pathways in #plants and how it acted as a springboard for further exploration of this extravagant universe https://plos.io/3DZgvps
Mosquitoes and the disease they spread are a concern worldwide, especially in regards to invasive species that bring diseases less common in a region and those species that focus on biting humans.
A consortium of European researchers have come together to target the asian tiger mosquito by using RNA interference and food sources that the larva will take up, preventing their reproduction.
#Mosquito #RNA #RNAi #Europe #Science #Biotech #Biotechnology #Biology #Scicomm
https://www.sciencedirect.com/science/article/pii/S0734975023000745?via%3Dihub
Repeated cycles of #SexChromosome conflict in #Drosophila simulans, involving X-linked protamine-derived loci & their autosomal #RNAi suppressors, drive #genome evolution, remodel #gametogenesis & may mediate reproductive isolation @lucksmith #PLOSBiology https://plos.io/43NIa7N
From our latest issue!
Xu et al. and the🎆potential of PM-RNAi🧬to control🛡️#Coccinellidae pests (like the 28-spotted #potato🐞ladybird) in 🥔crops.
https://doi.org/10.1111/jipb.13411
@wileyplantsci
#JIPB #PlantScience #phytopathology #CropScience #agriculture #RNAi ⚔️
New on Entomology Today: A study evaluating one of the first insecticides developed to use RNA interference as a mode of action finds significant effects on mobility, pupation, and reproduction of the target insect, the Colorado potato beetle. #entomology #insects #IPM #RNAi https://entomologytoday.org/2023/04/06/rna-interference-biopesticide-ledprona-colorado-potato-beetle/
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