The proteins that haunted scientists for 50+ years, transcription factors, scaffolding proteins, “undruggable” targets, are now vulnerable.
We're not improving old drugs. We're creating an entirely new class of medicine.
Welcome to the protein degradation revolution. 🧬🚀
What disease area needs this tech most? 👇 #PROTACs #DrugDiscovery #Biotech #Innovation
#PROTACS
Induced proximity in biology and therapeutics: Read the editorial to learn more about Induced Proximity and the articles you will find in the Special Issue. #PROTACs #RNATACs #Therapeutics #Velcrins #Wnt #KEAP1 #MolecularGlues #Bifunctional #PPI #Epigenetics #glycoRNA #photocatalytic #TPD #LyTACs https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00218-6?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Just learned about #PROTACs, a promising new class of drugs that target #protein degradation! Exciting times in the world of drug discovery. 🧪💊
Did you know that #PROTACs work by recruiting an E3 ubiquitin ligase to a target protein, tagging it for degradation by the proteasome? #sciencefacts 🤓🔬
I'm fascinated by the potential of #PROTACs to target disease-causing proteins that are traditionally considered "undruggable." Can't wait to see what the future holds. #drugdiscovery 🌟
The Ferguson lab is recruiting for multiple postdoc positions in San Diego! @FleurMFerguson
Chemical Biology / Neurodegeneration
Med Chemistry, Chemical Biology
Cancer Chemical Biology, Pharmacology
https://www.nature.com/articles/s41589-022-01218-w
Nice addition to the #targetedproteindegradation literature but I wouldn't describe it as "a new strategy of targeted protein degradation through direct substrate recruitment to the 26S proteasome" since Janse and Church first described this approach in 2004. https://pubmed.ncbi.nlm.nih.gov/15039430/ #PROTACs
@angadmehta It’s was good to visit again and thank you for the honor of inviting me to give this year’s Rinehart Lecture. #chemicalbiology #Protacs #naturalproducts
Quality criteria for traditional chemical #probes (reversible inhibitors of protein function or protein-protein interactions) have been broadly embraced by cell biology & target validation labs. Covalent protein modulators & small molecular protein degraders are now becoming very popular and will likely soon be used for target validation studies. This calls for a discussion about quality criteria for such probes as well. Here is a first proposal for such criteria for degrader probes. Comments are welcome. #TPD #PROTACs #OpenScience #SGC
Ni-catalyzed photoredox couplings in an oscillatory flow reactor (to allow for handling of slurries) for accessing versatile CRBN-engaging building blocks for #PROTACs. From our collaboration with the Kappe group at University Graz: now published in ChemCatChem https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202201184
Hi! I'm Sven, a #structural #biochemist who recently moved from #dundee, Scotland to #boston, MA to start a postdoc in the Brown lab at #harvardmedicalschool.
My broad interests are #structural_biology #proteinqualitycontrol #proteinfolding #ubiquitin #protacs #cilia #proteinengineering #cryoEM #proteintrafficking.
Also a #homebrewing and #baking enthusiast.
Looking for people with shared interests to follow!
I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup
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