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Tom Kindlontomkindlon@disabled.social
2026-01-30

2/
Sympathetic 2-minute video piece on drug trial that is recruiting in Florida, USA

"Groundbreaking Long COVID Clinical Trial at NSU | Researchers Explore New Treatment"

youtube.com/watch?v=BcS1QZY4ocg

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Video still with Dr Nancy Klimas Groundbreaking Long COVID Clinical Trial at NSU | Researchers Explore New Treatment Nova Southeastern University 4.49K subscribers Subscribe From an accredited US healthcare educator Learn how experts define health sources in a journal of the National Academy of Medicine 348 views Jan 28, 2026 #NSU #NSUFlorida #NovaSoutheasternUniversity Millions continue to struggle with the lasting effects of Long COVID years after the pandemic began. Researchers at Nova Southeastern University’s Institute for Neuro-Immune Medicine (INIM), led by Dr. Nancy Klimas, are conducting one of the few clinical trials focused on finding a cure for Long COVID. In this study, a monoclonal antibody treatment approved for COVID prevention is being tested as a possible treatment for the complex, chronic Long COVID condition. Over six months, researchers track patient responses, collect biological samples, and evaluate whether this treatment eases chronic symptoms and clears any lingering spike in protein from the initial infection. Funding for the study comes from the Florida Department of Health and the Schmidt Initiative for Long Covid (SILC). Long COVID patients can experience a range of debilitating symptoms that affect the brain, heart, and lungs, including fatigue and cognitive dysfunction, and one hundred patients are participating in this groundbreaking clinical trial to search for a cure.
Tom Kindlontomkindlon@disabled.social
2026-01-30

RE: disabled.social/@tomkindlon/11

This trial in Florida (USA) led by sympathetic researcher Dr Nancy Klimas is now recruiting.

Here is an extract from the latest Institute for Neuro-Immune Medicine newsletter.

Link: redcap.nova.edu/redcap/surveys

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

1/

Tom Kindlontomkindlon@disabled.social
2026-01-30

A patient who created a popular sheet on how to deal with somebody in postexertional malaise (PEM) has adapted it for hospital staff (repeat)

#PostExertionalMalaise #PEM #MEcfs #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome
@mecfs

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Hospital Guidance: Post-Exertional Malaise (PEM) - Care Requirements CLINICAL WARNING: When the patient is in PEM, any extra activity (sitting up, walking, answering questions) can worsen symptoms, reset recovery, and accelerate long-term decline. Strict protection of rest is required. Overnight Care Guidance Lighting and Noise: Keep the room dark and silent overnight. Avoid unnecessary door openings. Use minimal light if checks are required. Sleep Protection: Do not wake for routine observations unless clinically essential. Cluster any checks to reduce disturbance. Environment: Ensure call bell, water, and medications are within reach before settling for the night. Communication: Avoid questions or conversation if the patient wakes. Speak quietly and keep interactions minimal. Escalation: If pain, tachycardia, or instability occurs, respond calmly, minimise sensory exposure, and escalate as clinically indicated. Documentation: Overnight staff should record sleep protection strategies and PEM episode status at shift start and end. Personal Care - Showering and Hygiene Daily shower prompts are not required. Please be guided by the patient as to when capacity allows. General Principle: Patient will indicate readiness for washing or showering. No need to prompt daily. Frequency: Showering may be limited to once a week or less during severe PEM. Over-exertion can worsen symptoms. Alternatives: Patient may use wet wipes or gentle seated wash in lieu of shower as tolerated.
Tom Kindlontomkindlon@disabled.social
2026-01-30

News Release 29-Jan-2026

Multiple studies show: "metformin, a widely used & well-established medication, significantly reduces the risk of developing Long COVID when taken during or shortly after acute infection with #SARSCoV2"

eurekalert.org/news-releases/1

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #auscovid19 #CovidIsNotOver
@novid #novid

News Release 29-Jan-2026 Metformin shown to prevent Long COVID across risk groups in multiple randomized trials Peer-Reviewed Publication University of Minnesota Medical School FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail MINNEAPOLIS/ST. PAUL (1/29/2026) — Multiple randomized clinical trials and electronic health record studies now show that metformin, a widely used and well-established medication, significantly reduces the risk of developing Long COVID when taken during or shortly after acute infection with SARS-CoV-2. The findings were published today in Clinical Infectious DiseasesExternal link that opens in the same window. In the paper, the University of Minnesota Medical School research team provides information about metformin and summarizes several studies in low, standard and high risk populations that show taking metformin during or soon after infection with SARS-CoV-2 prevents the development of Long COVID. Notably, the research summarizes the number of patients needed to receive treatment in each study to prevent one case of Long COVID. On average across the four studies, one case of Long COVID is prevented for every 50 cases of acute SARS-CoV-2 treated with 14 days of metformin.
Tom Kindlontomkindlon@disabled.social
2026-01-30

From Germany:
News Release 29-Jan-2026

"How does #LongCOVID develop? New piece of the puzzle found"
"Big data study finds link to molecular cell state of immune cells"

eurekalert.org/news-releases/1

"We examined the cells using a so-called single-cell multiomics approach"

Hashtags:
@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

News Release 29-Jan-2026 How does Long COVID develop? New piece of the puzzle found Big data study finds link to molecular cell state of immune cells Peer-Reviewed Publication Helmholtz Centre for Infection Research FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail After infection with the SARS-CoV-2 virus, up to ten percent of those affected in Germany develop Long COVID. The symptoms associated with it, such as fatigue, concentration problems, respiratory issues, or neurological problems, can last for months or years. Furthermore, the clinical picture can differ from person to person. “Long COVID is an extremely complex disease with various manifestations,” says Prof. Yang Li, head of the “Computational Biology for Individualised Medicine” department and director of CiiM. “How and to what extent Long COVID develops is still largely unknown. Figuratively speaking, we are unfortunately only looking at an extremely incomplete puzzle.”
Tom Kindlontomkindlon@disabled.social
2026-01-29

New from Germany:

Microvascular Remodeling and Endothelial Dysfunction Across Post-COVID-19 and ME/CFS: Insights from the All Eyes on PCS Study

medrxiv.org/content/10.64898/2

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#MEcfs #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome
@mecfs

What is known? - PCS and ME/CFS are associated with persistent endothelial dysfunction and increased long-term cardiovascular risk. - Neurocognitive symptoms in post-viral syndromes have been linked to impaired neurovascular coupling. - Retinal vessel analysis provides a validated, non-invasive readout of systemic and cerebral microvascular health. What new information does this article contribute? - PCS is characterized by persistent functional and structural retinal microvascular dysfunction - Retinal endothelial dysfunction scales continuously with post-viral disease severity and is most pronounced in patients fulfilling ME/CFS criteria. - Retinal microvascular alterations are linked to inflammatory–endothelial activation and iron dysregulation, identifying a biologically coherent vascular phenotype.
Tom Kindlontomkindlon@disabled.social
2026-01-28

News Release 27-Jan-2026

COVID-19 viral fragments shown to target and kill specific immune cells in UCLA-led study

eurekalert.org/news-releases/1

An interesting angle to me but I'm no immunologist.

They talk about long Covid later on

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

News Release 27-Jan-2026 COVID-19 viral fragments shown to target and kill specific immune cells in UCLA-led study Clues about extreme cases and omicron’s effects come from a cross-disciplinary international research team Peer-Reviewed Publication California NanoSystems Institute FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Fragments of digested protein image: A UCLA-led international research team showed that fragments of digested proteins from the virus behind COVID-19 can attack certain immune cells that have spiky shapes, such as the T cell above. view more Credit: Figure adapted from Yue Zhang et al, PNAS 2026 New research shows that after the body’s defenses kill the virus behind COVID-19, leftover digested chunks of SARS-CoV-2 spike protein can target specific immune cells based on their shape. The revelations could explain why certain populations of cells that detect and fight infection are depleted in patients with severe COVID-19, and shed light on the omicron variant’s milder symptoms. The study, published in the Proceedings of the National Academy of Sciences, may launch a line of inquiry that informs new strategies for quelling the most serious symptoms of COVID-19. Led by a UCLA team, the scientific collaboration comprises nearly three dozen engineers, microbiologists, immunologists, chemists, physicists, medical researchers and analytical experts.
Tom Kindlontomkindlon@disabled.social
2026-01-28

News Release 27-Jan-2026

Altered brain connection found in people with ME/CFS and Long COVID

People with #MyalgicEncephalomyelitis / #ChronicFatigueSyndrome ( #MECFS) and #LongCOVID experience a disruption to their brain connectivity during a mentally demanding task.

eurekalert.org/news-releases/1

Peer-Reviewed Publication
Griffith University

Hashtags:
@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#CFS #PwME
@mecfs

News Release 27-Jan-2026 Altered brain connection found in people with ME/CFS and Long COVID People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID experience a disruption to their brain connectivity during a mentally demanding task. Peer-Reviewed Publication Griffith University FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Altered brain connection found in people with ME/CFS and Long COVID image: Altered brain connection found in people with ME/CFS and Long COVID view more Credit: Griffith University People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID experience a disruption to their brain connectivity during a mentally demanding task. The new Griffith University research, published today, used ultra-high field MRI technology to investigate the significant reduction in brain connectivity in specific parts of the brain.
Tom Kindlontomkindlon@disabled.social
2026-01-28

From the CDC:

Functional Limitations and Illness-Related Absenteeism among School-Aged Children with and without Long COVID, United States, 2022–2023

wwwnc.cdc.gov/eid/article/31/1

Screenshot from latest Science for ME weekly update

#LongCovidKids #LCKids @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

Functional Limitations and Illness-Related Absenteeism among School-Aged Children with and without Long COVID, United States, 2022–2023 - Volume 32, Supplement—February 2026 - Emerging Infectious Diseases journal - CDC — Nicole D. Ford et al. On the basis of the weighted samples, we estimated 1,538,000 (1.4%) school-aged children had long COVID at some point." "69.7% were 12–17 years of age, 59.4% were female and 40.6% were male, and 35.2% were experiencing long COVID symptoms at time of survey." "Compared with children who never had long COVID, children who had long COVID had a higher prevalence of functional limitations across 5 of the 6 functional domains."
Tom Kindlontomkindlon@disabled.social
2026-01-28

From Japan:

" #COVID19 infection shows significant association with increased autonomic dysfunction pharmacotherapy initiation, with a 36% rise in prescriptions over 8 months."

tandfonline.com/doi/abs/10.108

Screenshot from Science for ME update

#LongCovid #PASC #dysautonomia #POTS @pots #OI #OrthostaticIntolerance @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus #COVID #COVID_19 #COVIDー19 #SARSCoV2

Impact of COVID‑19 infection on subsequent prescriptions of autonomic dysfunction pharmacotherapy: a nationwide propensity‑score‑matched Cohort study in Japan — Daisuke Miyamori and Masanori Ito "COVID-19 infection shows significant association with increased autonomic dysfunction pharmacotherapy initiation, with a 36% rise in prescriptions over 8 months."
Tom Kindlontomkindlon@disabled.social
2026-01-27

From Spain:

Episodic memory deficits and processes in post-COVID condition

link.springer.com/article/10.1

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Episodic memory deficits and processes in post-COVID condition — Oliver-Mas et al. "the LASSI-L showed the highest correlation with the subjective cognitive complaints questionnaire." "This is consistent with the fact that LASSI-L is examining learning and recall during the effects of proactive and retroactive interference, and such interference in memory is likely to occur in daily living."
Tom Kindlontomkindlon@disabled.social
2026-01-27

Longitudinal Landscape of Long Flu and Long COVID

mdpi.com/2673-8112/6/1/21

Screenshot from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver
#PAIS

Longitudinal Landscape of Long Flu and Long COVID — Ming Zheng "The advent of Long COVID has propelled a significant expansion in our understanding of the long-term sequelae of viral infections" "this longitudinal analysis reveals that an influenza infection is not an isolated event" "precipitates a durable, multi-system legacy of incident morbidity that persists for up to five to fifteen years. This 'long flu' syndrome, characterized by significantly elevated risks of cardiovascular, neurological, and metabolic sequelae, represents a previously underappreciated public health burden."
Tom Kindlontomkindlon@disabled.social
2026-01-26

Australia:
$4.7 million for UNSW researchers to investigate long COVID

unsw.edu.au/newsroom/news/2026

Three UNSW Sydney projects have been awarded funding under the Medical Research Future Fund (MRFF) to improve the quality of care for people affected by #longCOVID.

Hashtags:

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
#COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid #CovidIsNotOver #auscovid19

Tom Kindlontomkindlon@disabled.social
2026-01-26

News Release 26-Jan-2026 from Japan

"Double trouble: Tobacco use and Long COVID"

"Smokers could be at higher risk of post-COVID symptoms"

eurekalert.org/news-releases/1

Sounds like most (if not all) of these don't have the ME/CFS-type of long Covid

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

News Release 26-Jan-2026 Double trouble: Tobacco use and Long COVID Smokers could be at higher risk of post-COVID symptoms Peer-Reviewed Publication Osaka Metropolitan University FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Tobacco and Long COVID image: Dual users of electric and combustible cigarettes may be at greater risk for Long COVID symptoms. view more Credit: Osaka Metropolitan University COVID-19 brought about lasting changes that are still being felt today in the post-pandemic era, with one being the unprecedented side effect known as Long COVID. Long COVID is characterized by symptoms affecting multiple organs and persisting for at least three months or longer after a COVID-19 infection. It has often been reported to be associated with advanced age, being female, obesity, and having other underlying conditions. However, there has not been a clear conclusion in its relation to smoking. A research group led by graduate
Tom Kindlontomkindlon@disabled.social
2026-01-25

Is long-term disruption of the renin-angiotensin-aldosterone system associated with long COVID? A retrospective cohort study among healthcare workers

link.springer.com/article/10.1

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers

Is long-term disruption of the renin-angiotensin-aldosterone system associated with long COVID? A retrospective cohort study among healthcare workers — Lange-Tal et al. "findings do not support the hypothesis that differences in the soluble levels of RAAS components contribute to the development of LC within the time points measured in this study." "small sample sizes and highly unstable biomarkers limit statistical power."
Tom Kindlontomkindlon@disabled.social
2026-01-25

Rethinking measurement of health outcomes in Long COVID: complexities, challenges and considerations

link.springer.com/article/10.1

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Rethinking measurement of health outcomes in Long COVID: complexities, challenges and considerations — Bhéreur et al. "This dynamic aspect of the condition adds to the complexity of timing and interpreting outcome measures." "symptoms and performance may be very different on an “average” day from those during PEM/PESE or flare-up state." "Furthermore, PEM/PESE onset can be delayed by hours or days after the trigger, further complexifying appropriate capture."
datum (n=1)datum@zeroes.ca
2026-01-24

Enrolling now in Canada, in Alberta, Ontario, and Quebec: a study evaluating Taurine Supplementation in Long COVID

clinicaltrials.gov/study/NCT06

#LongCOVID #PwLC #CovidIsNotOver

Tom Kindlontomkindlon@disabled.social
2026-01-24

Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone

mdpi.com/1422-0067/27/2/832

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone — Otsuka et al. "Although the peak responses were preserved across the axes, we observed consistent patterns of delayed peaks and sustained elevation at 120 min, especially in the responses of gonadotropins, PRL, and TSH." "the peak ACTH and cortisol responses to CRH and their recovery levels at 120 min were nearly normal, failing to detect clear HPA axis abnormalities."
Tom Kindlontomkindlon@disabled.social
2026-01-23

From Germany:

A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID

nature.com/articles/s41590-025

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19
#CovidLung

A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID — Kumar et al. "We also defined a distinct circulating CD14⁺ monocyte state (LC-Mo) associated with LC […] showed increased TGFβ/WNT–β-catenin signaling that increased over time and exhibited interindividual variability."
Tom Kindlontomkindlon@disabled.social
2026-01-23

From Italy:

Autonomic small fiber involvement in painful long COVID: a histological and clinical study

frontiersin.org/journals/human

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19

Autonomic small fiber involvement in painful long COVID: a histological and clinical study — Falco et al. "we observed histological evidence of postganglionic sympathetic fibers damage in dermal structures even in patients with normal [intraepidermal nerve fibre density], indicating that autonomic involvement can occur independently of [small fibre neuropathy]."

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