#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

Structural #basis for the #evolution and #antibody #evasion of #SARS-CoV-2 #BA286 and #JN1 #subvariants https://www.nature.com/articles/s41467-024-51973-8

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1

Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.

#Durability of #XBB15 #Vaccines against #Omicron #Subvariants, N Engl J Med.: https://www.nejm.org/doi/full/10.1056/NEJMc2402779?query=TOC&cid=DM2342986_Non_Subscriber&bid=-1971795569

Overall, the XBB.1.5 vaccines were effective against omicron subvariants, although less so against #JN1. Effectiveness was greater against #hospitalization and #death than against infection, and it waned moderately from its peak over time. The ramping and waning patterns were broadly similar to those of the bivalent boosters against BQ.1–BQ.1.1 and XBB–XBB.1.5.3

Characteristics of #JN1-derived #SarsCoV2 #subvariants #SLip, #FLiRT, and #KP2 in neutralization #escape, #infectivity and membrane #fusion http://biorxiv.org/cgi/content/short/2024.05.20.595020v1?rss=1

Interestingly, #antibodies in #XBB15 monovalent vaccinated hamster sera robustly neutralized FLiRT and KP.2 but had reduced efficiency for SLip.

[Correspondence] Antiviral humoral #immunity against #SARS-CoV-2 #omicron #subvariants induced by #XBB15 monovalent #vaccine in #infection-naive and XBB-infected individuals https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00784-3/fulltext?rss=yes

''Circulation of the #VUM #BA286 is now at 0.2% at national level.'' #italy #subvariants #SARS_COV_2 #update #report

[Correspondence] #Antibody #neutralisation of emerging #SARS-CoV-2 #subvariants: #EG51 and #XBC16 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00555-8/fulltext?rss=yes #research #covid19 #australia

“This #HighExposure phenomenon is particularly relevant to patients and staff in healthcare settings, where they may be working on or sharing wards with people who emit large quantities of #SARSCoV2.

In the age of #Omicron, in the context of high community #prevalence and rapidly evolving #subvariants that can evade #immunity, it seems particularly reckless to rely on #vaccine or prior #infection acquired immunity as the only mechanism of protection against infection” https://mstdn.ca/@Billius27/110968515538936395

#COVID19 immunity: Study shows extent | CTV News https://www.ctvnews.ca/health/covid-study-shows-impact-of-hybrid-immunity-in-canada-1.6518700 “The study found that high #vaccine coverage and population #immunity were "insufficient" to slow the "unprecedented increase" in infections from the #Omicron #variants and #subvariants.”

https://www.cmaj.ca/content/195/31/E1030

[Correspondence] #Bivalent #COVID19 #mRNA #vaccine against #omicron #subvariants in immunocompromised patients https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00357-2/fulltext?rss=yes #immunology #publichealth #epidemiology

The First Case of #CoInfection with #Omicron #Subvariants #BA5248 and #BF714 — #Chongqing Municipality, #China, February 2023, CCDC: http://dx.doi.org/10.46234/ccdcw2023.046

#Genotypic and Predicted #Phenotypic #Analysis of #SARS-COV-2 #Omicron #Subvariants in Immunocompromised Patients with #COVID19 Following #Tixagevimab-Cilgavimab Prophylaxis https://www.sciencedirect.com/science/article/pii/S1386653223000057?dgcid=rss_sd_all

People aren’t taking this seriously’: experts say US Covid surge is big risk

In the fourth #year of the pandemic, #Covid-19 is once again spreading across #America and being driven by the recent holidays, fewer precautions and the continuing evolution of Omicron #subvariants of the virus.
New sub-variants are causing concern for their #increased #transmissibility.

https://www.theguardian.com/world/2023/jan/15/covid-19-coronavirus-us-surge-complacency

Hem passat de tenir #variants #SARSCoV2 q es desplaçaven una a l'altra a tenir una sopa de #subvariants que no acaben d'imposar-se les unes a les altres. Crec que aquesta 2ona situació és pitjor que la 1era, si valorem només el vessant víric i no considerem l'hoste.
A nivell de circulació vírica (mai bona si intensa) teníem abans altes muntanyes i profundes valls; i ara les subvariants #omicron, q competeixen més q substituir-se, generen relleu ondulat però sense valls, són més aviat ALTIplans.

''#BQ1 and #XBB are new #subvariants of #Omicron which have become the dominant strains in some overseas countries and regions for their increased #transmissibility and immune escape capacity. ''

#China, #Shanghai has detected the #Omicron #subvariants #BQ1 and #XBB that have been prevailing in some overseas countries but experts said 2 strains were found in imported cases placed under closed-loop management which has not caused local #transmission, saying there is no need to hoard Montmorillonite {?} powder to relieve #diarrhea that can be caused by subvariant #XBB15. GT: https://www.globaltimes.cn/page/202301/1283058.shtml

''Xu Wenbo, head of the National Institute for Viral Disease Control and Prevention with the #China #CDC, also said that in the last three months, China has detected 130 #subvariants of #Omicron, such as #BF7, #BQ1 and #XBB entering the country, media reported on Thursday.'', https://www.globaltimes.cn/page/202212/1282939.shtml

''No #genomic #mutation was found in these #subvariants, which were all imported, according to Xu. In December, a total of 31 #Omicron subvariants were found to have been imported into #China, including #BQ1, #XBB and other subvariants that spread rapidly overseas, said Xu.''