#Virological characteristics of the #SARS-CoV-2 #NB181 #variant, https://etidiohnew.blogspot.com/2025/06/virological-characteristics-of-sars-cov.html

#Antigenic and #virological characteristics of #SARS-CoV-2 #variants BA.3.2, #XFG, and #NB181, https://etidiohnew.blogspot.com/2025/06/antigenic-and-virological.html

Identification & #genetic & #virological characterisation of a #human case of avian #influenza A #H9N2 virus from Eastern #India, https://etidiohnew.blogspot.com/2025/05/identification-genetic-virological.html

[Correspondence] #Virological characteristics of the #SARS-CoV-2 #LP.8.1 #variant https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00079-9/fulltext?rss=yes

LP.8.1 (JN.1.11.1.1.1.3.8.1), a descendant lineage of KP.1.1.3 (JN.11.1.1.1.3), is starting to spread worldwide. LP.8.1 has acquired nine spike protein mutations compared with JN.1, and eight amino acid residues differ between the spike proteins of LP.8.1 and XEC.

[Correspondence] #Virological and #antigenic characteristics of #SARS-CoV-2 #variants #LF.7.2.1, #NP.1, and #LP.8.1 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00015-5/fulltext?rss=yes

... several sublineages of #JN.1 are increasingly out-competing XEC and KP.3.1.1, exhibiting superior growth advantages; for example, LF.7.2.1, MC.10.1, NP.1, and, most importantly, LP.8.1 (figure A, B).

#Virological characteristics of the #SARS-CoV-2 #XEC #variant

Source: Lancet Infectious Diseases, Correspondence, {Excerpt} Altogether, here we showed that XEC exhibited higher pseudovirus infectivity and higher immune evasion than KP.3. Particularly, XEC exhibited more robust immune resistance to KP.3.3 BTI sera than KP.3.1.1. Our data suggest that the higher Re of XEC than KP.3.1.1 is attributed to this property and XEC will be a predominant SARS-CoV-2 variant in the…

https://etidioh.wordpress.com/2024/11/07/virological-characteristics-of-the-sars-cov-2-xec-variant/

#Virological #characteristics of the #SARS-CoV-2 #KP311 #variant http://biorxiv.org/cgi/content/short/2024.07.16.603835v1?rss=1

KP.3.1.1 exhibited a higher Re, higher pseudovirus infectivity, & higher neutralization #evasion than KP.3. These results align with our recent report that #JN1 subvariants with S:S31del (eg KP.2.3 & LB.1) exhibited enhanced Re and immune evasion compared to other JN.1 subvariants without S:S31del (eg JN.1, KP.2, & KP.3), highlighting evolutionary significance of S:S31del in JN.1 lineages.

#Virological characteristics of the #SARS-CoV-2 #KP3, #LB1, and #KP23 #variants, Lancet Infect Dis.: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00415-8/fulltext?rss=yes

JN.1 subvariants such as LB.1 (JN.1.9.2.1) and KP.2.3 (JN.1.11.1.2·3), which convergently acquired a deletion at the 31st position in S (Ser31del) in addition to the aforementioned substitutions, have emerged and spread as of June, 2024 (appendix pp 12–13).

#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1

Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.

[Correspondence] #Virological characteristics of the #SarsCoV2 #KP2 #variant https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00298-6/fulltext?rss=yes

Particularly, the KP.2 (JN.1.11.1.2) variant, a descendant of JN.1 bearing both S:R346T and S:F456L, is rapidly spreading in multiple regions as of April, 2024. Here, we investigated the virological properties of KP.2.

#Virological characteristics of the #SarsCoV2 #KP2 #variant http://biorxiv.org/cgi/content/short/2024.04.24.590786v1?rss=1

Particularly, KP.2 shows the most significant #resistance to the #sera of monovalent #XBB15 #vaccinee without #infection (3.1-fold) as well as those who with infection (1.8-fold). Altogether, these results suggest that the increased immune resistance ability of KP.2 partially contributes to the higher Re more than previous variants including JN.1.

#Genetic and #virological characteristics of a #reassortant avian #influenza A #H6N1 virus isolated from wild #birds at a live-bird #market in #Egypt, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06022-6

Phylogenetic analysis indicated that the Egyptian H6N1 strain A/Garganey/Egypt/20869C/2022(H6N1) has a unique genomic #constellation, with gene #segments inherited from different subtypes (#H5N1, #H3N8, #H7N3, H6N1, and #H10N1) that have been detected previously in AIVs from Egypt and some Eurasian countries.

#Virological and #clinical #outcomes in outpatients treated with #baloxavir or #NAIs for A(#H3N2) #influenza: A multicenter study of the 2022-2023 season https://pubmed.ncbi.nlm.nih.gov/38430970/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=10ykRO9og5pGdo51l9DEPEpOJ3DVFIn__QK2QPM3dci1C1dEYq&fc=None&ff=20240303191922&v=2.18.0.post9+e462414

-- These findings affirm baloxavir's virological and clinical effectiveness against A(H3N2) in the 2022-2023 season and suggest limited clinical influence of post-treatment resistance emergence.

#Virological characteristics of the #SARS-CoV-2 #Omicron #XBB15 #variant, Nat Commun.: https://www.nature.com/articles/s41467-024-45274-3

-- We provide intrinsic pathogenicity of XBB.1 & XBB.1.5 in hamsters. ...we find that #ORF8 nonsense mutation of XBB.1.5 resulted in impairment of #MHC suppression. In vivo experiments using recombinant viruses reveal that XBB.1.5 mutations are involved with reduced virulence of XBB.1.5... our study identifies 2 viral functions defined difference between XBB.1 & XBB.1.5.

[Correspondence] #Virological characteristics of the #SARS-CoV-2 #JN1 #variant https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00813-7/fulltext?rss=yes

-- JN.1 harbours Leu455Ser and three mutations in non-spike proteins (appendix pp 17–18). Spike protein mutation Leu455Ser is a hallmark mutation of JN.1: we have recently shown that HK.3 and other flip variants carry Leu455Phe, which contributes to increased transmissibility and immune escape ability compared with the parental EG.5.1 variant.

R to @ECDC_EU: By providing a concise summary of the #epidemiological and #virological situation for respiratory virus infections, #ERVISS supports #PublicHealth decision-makers to take timely, well-informed decisions to limit the impact on healthcare systems and the wider public.

🐦🔗: https://nitter.cz/ECDC_EU/status/1717166324508405937#m

[2023-10-25 13:08 UTC]