#patchclamp

Dr. Marianne Musinszkimariannemusinszki@fediscience.org
2024-12-20

📢 2 PhD positions in ion channel research available!

I want to share our latest job offers for a carrier in science - we have 2 open positions starting in the beginning of next year for PhD students. PhD students will learn & employ the PatchClamp technique to investigate structure-function relationships and pharmacology of ion channels, mainly potassium channels.
Enthusiastic about science?
Maybe something to think about over the holidays?
Have a look (english text can be found below the official german version in the documents)!

uni-kiel.de/personal/de/stelle

uni-kiel.de/personal/de/stelle

#academia
#science
#PhD
#phdPosition
#ion_channels
#patchclamp
#PotassiumChannel
#electrophysiology

collage showing a cartoon of a molecule binding to a protein structure, current traces from an electrophysiological experiment, and photos of xenopus oocytes in a recording chamber with an application system
2024-04-19

[2/2] For all our #nerds out there (❤️): Nerve cells in the human neocortex are wired directionally & acyclically.

How is that measured? With glass micropipettes positioned precisely down to the nanometer to touch the neurons and track their activity. To listen in on communications by ten neurons at once, the team built a ten-arm robot 🤖 (shown here 👇 during rinsing).

@YangfanPeng #research #CharitéNeuro #MachineLearning #ScienceMastodon #neuroscience #MultiPatch #PatchClamp #AI

2023-05-28

#Singlechannel recordings of TRPV1 show strong coupling of permeant ion species to #ionchannel opening (completely different from other non-selective channels like AMPAR). #biophysics #patchclamp

biorxiv.org/content/10.1101/20

single channel recordings of TRPV1 channel, colour-coded by the permeant ion
2023-01-02

New #introduction for neuromatch.social 🙂​

My group investigates and defines cell types and neural circuits of the #thalamus, #hippocampus, and #cortex that contribute to spatial #memory processes.
These processes break down in #Alzheimer's disease. To understand the causes/triggers of #neurodegeneration, we study early-stage #Tau #pathology in the human #brain and in mouse models.

I previously defined various types of retinal ganglion cells using ex vivo #patchclamp recordings during my PhD in #Basel, before moving to #Oxford to work on #GABAergic #neurons of the #hippocampus, followed by the #medialseptum. My favourite technique is in vivo #extracellular recordings and #juxtacellular labelling as it enables identification of single #cells based on their firing patterns, #axon terminal distribution, and #neurochemical profile.

As an #experimentalist, my expertise is primarily in vivo #neurophysiology and #neuroanatomy. I am also interested in #consciousness, the origins of #memory, and regulation of #neuronal activity and #behaviour by #neuropeptides.

Patrick MacDonaldbcellorg@mstdn.ca
2022-12-19

One of the things that our group does is process pancreas from organ donors for diabetes research. We isolate pancreatic islets that make insulin - and these are used by groups in North America and Europe to understand the underlying causes of diabetes. #introduction #introductions

Here is our last isolation of 2022. These are from a donor with un-diagnosed diabetes - will be used for #electrophysiology #patchclamp #patchseq #genomics ant lots of other studies. More info at www.bcell.org

Pancreatic islets of LangerhansIslets under a microscope
Patrick MacDonaldbcellorg@mstdn.ca
2022-12-17

So now I’ve parked my twitter account. Suggestions on who I should follow here? Interests in #science #academia #diabetes #biobanking #reserach #cellbiology #electrophysiology #patchclamp #genomics #running #nature #alberta #canada #edmonton #yeg #ualberta #hockey #oilers
And here’s a dog pic…

2022-11-29

Dissertation submitted, now time to make a tantalizing PowerPoint to convince a crowd of patch clampers about the virtues of our lord and savior: multi electrode array extracellular recordings.
Any ideas about self deprecating jokes about array recordings to lower their guard in preparation for a bait and switch?
#neurosciene #thesis #patchclamp

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