#phages

Massimo LucianiNetMassimo
2025-11-12

An article published in the journal "Microbiology Spectrum" reports the results of experiments based on the use of genetically modified to combat strains of Escherichia coli that developed resistance to various antibiotics. These findings offer a way to neutralize these bacteria and new insights into the interactions between bacteriophages and bacteria.

english.netmassimo.com/2025/11

2025-09-20

One step closer to manufacturing #pandemics. The first successful AI-design of E. coli #phages with new properties. Applied by zealots to human pathogenic viruses ... and we have a solution to Fermi's paradox. nature.com/articles/d41586-025

2025-09-03

Yesterday session on #Clostridia #phages and surfaces was brilliant, with personal highlights being Dr Anna Barwinska-Sendra's work on diversification of #Cdiff #S-layers, Louis-Charles Fortier's talk on how phage/S-layer specificity and Lea Huet's work in PSII S-layer anchoring. #clostpath14

Amelia Cervera 🧬ameliacervera@genomic.social
2025-07-23

Viromics approaches for the study of viral diversity and ecology in microbiomes.

#Virology #Viromics #Phages #GenomeResolvedMetagenomics

nature.com/articles/s41576-025

2025-05-20

Defence mechanism inception!

Listeria prophages protect their host bacteria with anti-phage systems, leaving them susceptible to their own defence systems - read how this may actually be an evolutionary advantage!

#preLight from Briana Guzman, Noah Franz #ImmunobiologyUA ! ⬇️ 👀

👉 prelights.biologists.com/highl

#microbiology #immunobiology #bacteria #infection #phages #prophages

2025-05-16

#Phages (viruses that kill bacteria) are considered a potential approach to combat multidrug-resistant pathogens. However, they don't always deliver the desired results on their own. A research team at #CharitéBerlin has now demonstrated that combining phages with an antibiotic is much more effective, at least in the lab, against a form of #pneumonia caused by multidrug-resistant bacteria 💪👩‍🔬.

👉 charite.de/en/research/paper_s

#CharitéPaper #medicine #science #research #MedMastodon #AMR #antibiotics

Electron microscope image of a bacteriophage attaching to and infecting the bacterium Pseudomonas aeruginosa. Black and white image. A bacterium runs through the picture as a gray elongated area. A small “pin with a head” can be seen on its surface (the phage).  © Charité | Shailey Gale Twamley
2025-04-28

Exciting work from the Hsu lab at Virginia Tech! They developed a cool way too knock down phage abundances to examine their role in the gut.

"A bacteriophage-conditional mouse model reveals the impact of phages within a conventionally colonized gut microbiota"

sciencedirect.com/science/arti

#microbiome #microbiology #phages

2025-04-08

The BASEL collection of E. coli #phages is limited by its host strain. @aharms485 &co use a modified host to add 36 new phages, revealing roles of O-antigen in host recognition & R-M systems in immunity @PLOSBiology plos.io/4jirGvX

The illustration shows all isolates of the complete BASEL collection with their Bas## identifiers. Isolates are sorted by morphotype and their current ICTV classification. The color code distinguishes phages based on morphotype and genome size. For siphoviruses, small phages (ca. 30–50 kb) are shown in red, medium-sized phages (ca. 50–100 kb) are shown in orange, and large phages (>100 kb) are shown in yellow. For myoviruses, small phages (ca. 30–100 kb) are shown in green, medium-sized phages (ca. 100–150kb) are shown in cyan, and large phages (>100kb) are shown in blue. For podoviruses, small phages (ca. 30–50 kb) are shown in violet, and medium-sized phages (ca. 50–100kb) are shown in pink.
Leibniz-Institut DSMZdsmz@wisskomm.social
2025-04-04

Apply now 👉 Master thesis “Evaluating Bacteriophage-Antibiotic Combinations and Protocols for the Eradication of Enterococcus faecium in the Gut”

This project aims to identify the most effective in vitro approach to reducing and ideally eliminating E. faecium bacterial load.
More information 👉 dsmz.de/dsmz/career/masterarbe

#masterthesis #braunschweig #phages #bacteria #gut #antibiotics

2025-04-02

The biology and ecological impact of #phages in the mammalian gut are poorly understood. This Primer explores a @PLOSBiology study that provides a glimpse into the disruptive biology of the #Hankyphages, parasites of the ubiquitous Bacteroidaceae. Primer: plos.io/3RukgtJ Paper: plos.io/41Rr22S

Schematic showing how Hankyphage has multiple mechanisms of generating randomness in its own and its bacterial host genomes. (1) RepCHP-dependent spontaneous induction of prophage, (2) incomplete packaging leading to defective virions and free tails in combination with low-level complete packaging and potential transduction events, (3) intrachromosomal transposition leading to genetic variation in the host genome, and (4) diversity generating retroelements within the phage genome impacting the host range of the phage. Created with BioRender.
2025-02-18

Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage

nature.com/articles/s41587-025

#phages #viruses

2025-01-27

Gram-neg bacteria can resist #phages by modifying their LPS, also affecting #antibiotic susceptibility. @lavishaparab &co show that antibiotic concentrations influence evolution of E. coli phage resistance, leading to enhanced phage-antibiotic synergy #plosbiology plos.io/4hPmO0X

A schematic of the fluctuation test and expected results. Top: phage only. Middle: Phage plus chloramphenicol. Bottom: Phage plus gentamicin. Right: expected LPS phenotypes for the three scenarios. Adding chloramphenicol at subinhibitory concentrations is predicted to reduce rates of resistance to ΦX174, due to inhibition of the growth of deep rough LPS phenotypes. Gentamicin, however, is predicted to have a much lower effect on the rate of resistance to ΦX174.
2025-01-16

Bacteriaphages are a promising, albeit hard to handle, alternative to antibiotics. Since bacteria create antibiotics to use against their opponents, it shouldn't really come as a surprise that they also use phages for the same purpose.
But it does surprise me.
eurekalert.org/news-releases/1
#sciencenews #bacteria #phages

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