🧬 How do AlphaFold2 and ESMFold stack up when it comes to functional annotation?

🔗 AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.01.008

📚 CSBJ: https://www.csbj.org/

#AlphaFold2 #ESMFold #AIinScience #ProteinStructure #Enzymes #Pfam #UniProt #AlphaFold #HumanProteome #FunctionalAnnotation #AIinBiology #ComputationalBiology #FunctionalGenomics

#SaprotHub: Making #protein #modeling accessible to all biologists:

-create & train own #DeepLearning models without the need for advanced #MachineLearning & coding expertise

https://doi.org/10.1101/2024.05.24.595648
#DIYbio #bioinformatics #CompChem #AI #ML #KI #LLM #AF2 #ESMfold #ColabFold #sciece #research

Currently testing Folding Playground

A one-step solution for comparing #alphafold #omegafold #esmfold and #openfold #AI #protein #structure

https://www.sphinxbio.com/post/folding-playground

A new perspective paper in JCIM "Best Practices of Using AI-Based Models in Crystallography and Their Impact in Structural Biology" written with Marc Graille and
@sacquin_mo to explore how #AlphaFold, #RosettaFold, #EsmFold have modified the field of X-ray crystallography

https://doi.org/10.1021/acs.jcim.3c00381

Look forward to seeing all the competitive advances in the coming few years; will be fun to follow developments in the folding world along with all the advances spurred by ChatGPT/Bing/Bard/... too!
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RT @ScienceMagazine
In a Science study, @MetaAI researchers show the power of a large language model, #ESMFold, to enable protein structure prediction and analysis.

Using ESMFold, they generated a database—the ESM Metagenomic Atla…
https://twitter.com/ScienceMagazine/status/1650129931421057026

RT@thesteinegger@twitter.com Martin Steinegger:

#Foldseek's webserver now allows predicting #structures thanks to the great #ESMfold API. Just paste an amino acid sequence, click "PREDICT STRUCTURE" and search against structures from #ESMatlas, #AlphaFoldDB, #PDB & more. Work by @milot_mirdita
. Check it out at http://search.foldseek.com

It does not stop to amaze me what type of analyses you now have at your fingertips!

Does anyone have first experience with #ESMFold?

#sciencemastodon