Dr Ron Vale

The Impact of AlphaFold on Cell Biology

Cellular Interfaces Seminar

Friday 20 June, 11.15am-12.15pm, GLT2, Medical School Building

Note the change of venue!

#CellBiology #AlphaFold #biophysics

Tomorrow we are hosting a talk from Ron Vale:

The Impact of AlphaFold on Cell Biology
Dr Ron Vale, Emeritus Professor of Cellular and Molecular Pharmacology, University of California

Cellular Interfaces Seminar
Friday 20 June, 11.15am-12.15pm, A151/MBU, Medical School Building

#CellBiology #AlphaFold #biophysics

[Перевод] Потеря работы из-за ИИ: насколько реальна угроза? Мнение Демиса Хассабиса

Имя Демиса Хассабиса — синоним амбициозных проектов в области ИИ. От разработки легендарной игры Theme Park до создания AlphaFold, решившей «нобелевскую» задачу биологии, и теперь — к AGI , искусственному интеллекту уровня человека. Глава DeepMind утверждает: шанс увидеть AGI в ближайшее десятилетие — 50/50. Этот прогноз одновременно восхищает и пугает. Ведь за ним маячит призрак массовой потери работы из‑за ИИ. Насколько реален апокалипсис профессий? И есть ли свет в конце тоннеля общего искусственного интеллекта? Погружаемся в мысли одного из главных архитекторов нашего будущего.

https://habr.com/ru/companies/bothub/articles/919718/

#демис_хассабис #agi #deepmind #google #alphafold #го #шахматы #ai_mode #ai_overviews #колонизация_космоса

#AlphaDesign: An #OpenSource de novo #protein #design framework based on #AlphaFold:
https://doi.org/10.1038/s44320-025-00119-z
#DIYbio #CompChem #bioinformatics #AF

Ha, I was right.

"The goal of OpenBind is to generate a vast collection of matched protein structure and ligand binding data. This dataset will be a crucial tool for training and validating the next generation of Al models for discovering new drug candidates."

The subtext to this is that current versions of AF3 clearly aren't good enough.

#Crystallography #Alphafold @strucbio

https://www.linkedin.com/posts/isomorphic-labs_uk-to-become-world-leader-in-drug-discovery-activity-7338260916783788033-lN09?utm_source=social_share_send&utm_medium=android_app&rcm=ACoAAAdfFmsBBezd_7-Uygx62K3Df4DQ3k9G3os&utm_campaign=copy_link

🧩 What happens when we put AlphaFold2’s predictions to the ultimate test—across species and structure types?

🔗 Comprehensive assessment of AlphaFold’s predictions of secondary structure and solvent accessibility at the amino acid-level in eukaryotic, bacterial and archaeal proteins. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.047

📚 CSBJ: https://www.csbj.org/

#AlphaFold #Bioinformatics #StructuralBiology #AlphaFold2 #ProteinStructure #ProteinPrediction #AI

Improved 3D prediction from #alphafold (2/3) . Result from #casp15 ➡️ Deep-learning-based single-dome and multidomain protein structure prediction with D-I-TASSER. Nature Biotechnology https://zhanggroup.org/D-I-TASSER/help.html#casp15

🧬 New review out in Drug Discovery Today:

🔗 https://doi.org/10.1016/j.drudis.2025.104382

We take a critical look at how AI — especially AlphaFold(-Multimer/3) — has changed protein complex prediction.

End-to-end models work well for rigid complexes. Flexibility, disorder, and transient interfaces remain unsolved.

AI is shiny. Biology is complicated. We map what’s working, what isn’t, and what’s next.

#ComputationalBiology #Bioinformatics #DrugDiscovery #AlphaFold

#uniprot just hides the controls.. so you can't even try to full screen. but you can fortunately link out the #ebi #alphafold site where (ctd..)

🧬 How do AlphaFold2 and ESMFold stack up when it comes to functional annotation?

🔗 AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.01.008

📚 CSBJ: https://www.csbj.org/

#AlphaFold2 #ESMFold #AIinScience #ProteinStructure #Enzymes #Pfam #UniProt #AlphaFold #HumanProteome #FunctionalAnnotation #AIinBiology #ComputationalBiology #FunctionalGenomics

The new #AlphaEvolve from #DeepMind promises a general-purpose #AI for science - from solving math puzzles to improving chip designs, maybe as revolutionary as #AlphaFold. But until an open-source version is vetted by researchers, skepticism remains the safest policy. #Google #ScienceAI #ResearchSky

DeepMind unveils ‘spectacular’...

📰 «AlphaFold, un ejemplo de IA que fue muy útil»
🔗 https://proxy.jesusysustics.com/2025/05/13684/

Vídeo de Veritasium donde nos explican el proceso que llevó a desarrollar AlphaFold, una IA de Alphabet (Google) verdaderamente útil para la ciencia al ayudar a determinar la estructura de todas las proteínas.

Es un soplo de aire fresco recordar que los avances en ciencia también sirven para esta clase de cosas, aunque al mismo tiempo es fácil fijarse en que de esto hace cinco años y el boom de los LLM probablemente ha quitado el foco en los logros científicos para centrarse en logros comerciales.

#️⃣ #Alphabet #AlphaFold #Ciencia #curiosidad #InteligenciaArtificial #vídeo #YouTube

💥 Революция в биохимии! ИИ научился предсказывать и даже создавать белки 🧬. AlphaFold и Rosetta меняют всё: от медицины до экологии. Это начало новой эры в науке! 🔬🤖 #AlphaFold #ИИ #биохимия #наука #технологии #NobelPrize #AI #биотех #proteinfolding #DeepMind

Подробнее: https://scientia-et-innovatio.blogspot.com/2025/05/blog-post.html

The structure of a newly designed protein featuring a rare left-handed βαβ motif could not be solved by molecular replacement using the AlphaFold2 model @ActaCrystF @IUCr #DeNovoProteinDesign #LeftHandedBetaAlphaBetaMotif #AlphaFold https://doi.org/10.1107/S2053230X25003097

🚀 What role does protein design play in advancing next-gen optogenetic tools?

🔗 Protein design accelerates the development and application of optogenetic tools. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.014

📚 CSBJ: https://www.csbj.org/

#Optogenetics #ProteinEngineering #Neuroscience #AlphaFold #ProteinDesign #SyntheticBiology

“Ik kijk alvast uit naar de koppeling van AI-software met robotica om systemen te creëren die niet alleen leren uit data, maar die hun voorspellingen ook verifiëren en nieuwe data uit zelf ontworpen en uitgevoerde experimenten genereren, om daar vervolgens weer uit te leren. Ik hoop dat ziekten die vandaag onbegrijpelijk of onbehandelbaar lijken in de nabije toekomst kunnen worden aangepakt met precisie-interventies op moleculair niveau. Zo bouwen we niet alleen betere processen, maar meteen een betere toekomst.”

#AI #robotica #automatisatie #AlphaFold #LLM

https://www.tijd.be/opinie/column/de-wetenschappelijke-methode-2-0/10605202.html

🤖 AI | ⚛️ QUANTUM
🔴 Google Bets Big on Quantum-AI Synergy

🔸 New chip “Willow” achieves breakthrough error reduction via more qubits.
🔸 May generate novel training data as AI hits internet data limits.
🔸 Could power models like AlphaFold with quantum-informed insights.
🔸 Google targets real-world quantum use case in 5 years.

#Google #QuantumComputing #AI #Willow #DeepMind #AlphaFold

🧠 Can post-processing and deep learning push protein prediction to near perfection?

🔗 Post-processing enhances protein secondary structure prediction with second order deep learning and embeddings. DOI: https://doi.org/10.1016/j.csbj.2024.12.022

📚 CSBJ: https://www.csbj.org/

#DeepLearning #Proteins #PSSP #ProteinStructure #ProtBERT #CNN #AlphaFold #AI #Proteomics

🔬 La rivoluzione medica è alle porte con Google's #AlphaFold! Anticipando stravolgimenti nella medicina tradizionale. #MedicinaDelFuturo #socialmedia #artificialintelligence #technology

🔗 https://aibay.it/notizie/lintelligenza-artificiale-verso-una-medicina-rivoluzionaria-2025-03-28

Isomorphic Labs: AI-driven drug discovery 🔬

Secures $600M funding to advance innovative drug design

London-based company revolutionizes pharma with AI platform

#IsomorphicLabs #AIDrugDiscovery #AlphaFold #BiotechFunding

https://masonq.com/2025/04/01/fundraising-%f0%9f%87%ba%f0%9f%87%b8-isomorphic-labs-secures-600-million-to-advance-ai-driven-drug-discovery/