#Malignancy

2024-12-19

ONSLAUGHT KOMMAND – Malignancy
eternal-terror.com/?p=64650

RELEASE YEAR: 2024BAND URL: godzovwarproductions.bandcamp.

Malignancy is quite possibly one of the most inhuman and raw-sounding musical documents that I have come all year, and I am perfectly okay with that, thank you very much.

The guitar tone is akin to slime and immediately establishes an atmosphere that can only be described as utterly unpleasant. With its […]

#blackMetal #godzOvWar #grindMetal #grindcore #malignancy #onslaughtKommand #rawBlackMetal

2024-08-16

Evilyn – Mondestrunken Review

By Dear Hollow

At first glance, it appears that international death metal act Evilyn only has your demise and destruction in mind. Mondestrunken is uncompromisingly heavy, riffs pushed to their shimmering limits like oil from the collapsing god machine, hellish growls from beyond the stars, and drums funneled through warp speed directly into the collapsing horror of a black hole. It feels like a background of cosmic noise, lifeless, unfriendly, and directionless, but patience yields results: obelisks emerge into the view. Not that they were ever absent, but that our eyes could not behold them. Beneath the fray of entropy, the eyeless stars, and the unending weight of time, patterns emerge. Lifelessness itself resurrects. The dead shall rise again. We were never alone, and that should make us more terrified than ever.

Evilyn was originally founded by Coma Cluster Void’s Jeanne Comateuse, attempting to make cosmic-themed old school death metal with a substantial hit of dissonance. With debut EP Inside Shells, the template was set: devastating death metal with shifting nebulae of tempos and time signatures alongside ruthless discordance. Evilyn’s lineup has shifted,1 its sole remaining member, guitarist/vocalist Anthony Lipari of Thoren, now including bassist Alex Weber of Malignancy and drummer Robin Stone of Norse and Ashen Horde, but the emphasis is as uncompromising as ever. First full-length Mondestrunken (German for “moon-drunk”) is as punishing as it is puzzling, a relentless bombast of death metal insanity fractured and splattered across the face of infinity.

Across thirty-seven minutes, Evilyn creates an OSDM template that is splintered through the fractured light of an alien prism, the result just as chaotic and alienating as you would expect – dissonance is relentless, the tempos and rhythms are constantly shifting, and Lipari’s vocals remain in deep growl mode. Initially overwhelming in terms of utter saturation, repeated listens unearth more and more. Contrary to the dissonance-for-dissonance’s-sake screeching of Mithridatum or Scarcity, or the improvised assaults of Acausal Intrusion or Ar’lyxkq’wr, Evilyn’s palette emerges in the form of motifs. While initially an apparent clusterfuck of discordance and chugs, blastbeats, and aggressing plodding, the motif gradually reveals itself and the song suddenly makes sense – these take several forms. While the off-kilter morphogenetic riffs of “Dread,” “Limits,” “Penance,” and “Slithering” ground their respective sounds like a traditional Morbid Angel blueprint, the pinch harmonics of “Omission” and “Forgotten” are a flaying reminder of pain. “Forgotten” and “Eat the Elite” explore their riffs with careful precision, each rendition more warped and rusted than the last.

The most tantalizing tracks aboard Mondestrunken are the ones with whom only a framework or structure becomes the motif, Evilyn soaring in mood and madness. The album title is most apparent in “Forgotten,” which truly feels like a cosmic drunken dissodeath passage, deepening in intricacy as it continues – its pinch harmonics nearly a misdirect to the approaching doom – while “Interwoven” lives up to its name with a dynamic structure of growing dissonance with each worming riff. “Bloviate” approaches its sound with a “traditional” proto-chorus, a midsection of contemplative open strums that add greater monolithic weight to the obliteration surrounding it. Resounding highlights are centerpieces “Penance” and “Vacuous,” their mercilessly mechanical sound achieving a hypnotic effect. The clockwork guitar plucking in the former collapses to dizzying shredding and animalistic blastbeats that rend planets, while the dissonance achieves a distinctly dying warble. The latter’s constant shifting between 6/8 and 4/4 enacts a cosmic pendulum, swaying between destruction and creation, the clarity of its cohesive conclusion feeling more punishing than the chaos surrounding it. Overall, Mondestrunken’s viciousness is palpable, the breadth organic – continuous and relentless hiss against the breath of life – each instrument organic and audible through the alien shimmering. Evilyn embraces experimentation with just a kernel of a tenet that keeps the mind secured to mortal realms.

Don’t be surprised if you hate Evilyn’s brand of bombastic saturation off the bat. Its dissonance is unending, its vocals one-dimensional, and shifting passages feel like cosmic whiplash again and again. However, it’s a surefire slow burn in spite of its relentless attack, its revelations feeling like the solution of a difficult cosmic puzzle and the kernel of accessibility blooming into monolithic significance. Its audience is limited, but fans of Fractal Generator, Artificial Brain, Aseitas, and Asystole – rejoice! For those willing to ride Evilyn’s warped spiral of the abstract and maddening, Mondestrunken’s secrets are revealed with tantalizing fulfillment.

Rating: 4.0/5.0
DR: 9 | Format Reviewed: 320 kb/s mp3
Label: Transcending Obscurity Records
Websites: evilyndm.bandcamp.com | facebook.com/evilyndeath
Releases Worldwide: August 16th, 2024

#2024 #40 #AcausalIntrusion #ArLyxkqWr #ArtificialBrain #Aseitas #AshenHorde #Asystole #Aug24 #AvantGardeDeathMetal #ComaClusterVoid #DeathMetal #DissonantDeathMetal #Evilyn #FractalGenerator #InternationalMetal #Malignancy #Mithridatum #Mondestrunken #MorbidAngel #Norse #OldSchoolDeathMetal #OSDM #Review #Reviews #Scarcity #TechnicalDeathMetal #Thoren #TranscendingObscurityRecords

🤘 The Metal Dog 🤘TheMetalDog
2024-06-12
Matt WillemsenNonog@fedibird.com
2023-09-02

Cracking Cancer’s Origin Story: Stanford Researchers Uncover Predictable Plot Line
Researchers at Stanford Medicine have found that cancer cells undergo a series of specific and predictable genetic changes years before they become pre-malignant. This study could enable earlier diagnosis and intervention, potentially stopping cancer development at its earliest stages.
scitechdaily.com/cracking-canc #cancer #predictable #genetic #changes #malignancy

2023-07-17

Issue 14:
Highlight on #ROR1 and #pancreatic #malignancy

Review on viral recognition and #antiviral #interferon response

#Autophagy news from plants and mammals
How #p97 disassembles a regulatory protein complex
Developmental #axon pruning by a #phospholipid #scramblase

Cover: Elisa Nerli, Caren Norden and colleagues

embopress.org/toc/14602075/202

This cover highlights the article Deterministic and probabilistic fate decisions co‐exist in a single retinal lineage by Elisa Nerli, Caren Norden and colleagues. A combination of live imaging and stochastic modelling of single lineage decisions in the zebrafish retina reveals how different neuronal types arise in the correct proportions during development. The cover shows the retina at three days post‐fertilisation, when most neurons are formed and occupy different layers. The different layers are outlined with phalloidin staining in magenta, Muller glial cells are labelled in yellow and retinal ganglion cells in cyan. (Scientific image by the authors)
Insights Into ImagingInsightsImaging
2023-07-07

and feature-based blending ensemble classifier for risk prediction in cystic renal lesions (CRLs). (Quan-Hao He et al.)

Click to read more 👉 insightsimaging.springeropen.c

2023-07-06

Inducing #ferroptosis is a key approach to inhibiting #tumor progression, but how is it regulated? Study shows that #HBP1 #nanoparticles enter tumor cells, inducing ferroptosis & inhibiting #malignancy by regulating the HBP1-UHRF1-CDO1 pathway #PLOSBiology plos.io/3NEILSO

Insights Into ImagingInsightsImaging
2023-05-31

Educational Review: Mimickers of : vital to clinical pratice, playing key role in ensuring appropriate clinical management. (Mary Guirguis et al.)

Want to learn more? Click the link below ⬇️
insightsimaging.springeropen.c

European RadiologyEurRadiology
2023-05-17

"O-RADS score is a robust, reproducible, and simple way to assess the risk of of an adnexal mass referred after ." - Thomassin-Naggara et al.

🔗 auntminnie.com/index.aspx?sec=

Scientific Frontlinesflorg
2023-05-08

is the fifth most commonly diagnosed worldwide. It ranks a sad third in cancer-related causes of death. The reason for this is late diagnosis coupled with rapid spread of cells in the body.

sflorg.com/2023/05/med05182301

Gonzalogcordova
2022-12-30

Recently Published!

Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management

link.springer.com/chapter/10.1

2022-12-06

The Uprising of Mitochondrial DNA Biomarker in Cancer

Advances in predictive #diagnostic and #precisionmedicine, can lead to powerful discoveries and treatments for patients. #Cancer cells acquire functional capabilities to survive, proliferate, and circulate due to an enabling characteristic called genomic instability. Genomic maintenance systems have the ability to spot and repair any #DNA defects, while cancer cells increase the rates of mutation that orchestrate tumorigenesis. Chromosomal instability (CIN) is one of the most frequent changes observed in cancer cells, which often results from aberrations in chromosome structures and numbers. The second section of the paper focuses on #biomarkers, which are substances, structures, or processes that can influence or predict the incidence and outcome of a disease. There are three classifications of biomarkers: exposure, effect, and susceptibility. Biomarkers of exposure measure exogenous chemicals or their metabolites within an organism, while biomarkers of effect measure alterations of endogenous factors caused by exposure to an exogenous agent. Biomarkers of susceptibility measure genetic polymorphism predisposition of individuals and their external multifactorial influencers. Surrogate endpoints are often used to substitute clinical endpoints, and biomarkers can be used as a screening tool for an early indicator of #malignancy-risk development. They can also be used as diagnostic aids and prognostic biomarkers, as well as predictive biomarkers to identify the sensitivity and/or resistance of cancer patients towards specific agents or #medical product exposure.

The communication between the nucleus and mitochondria of a cell is known as intergenomic #crosstalk and it is bidirectional, meaning it can go both ways. It is important for regulating energy metabolism and tumor suppression. The communication is achieved by pathways such as anterograde #signaling and retrograde signaling. Anterograde signaling is when the nucleus controls gene transcription and cytoplasmic mRNA translation in response to external signals. Retrograde signaling is when mitochondrial dysfunction or loss of mitochondrial #membrane potential triggers communication with the nuclear genetic compartment. This communication is important for #homeostasis adaptation and can detect any nuclear damage or nuclear stress.

#Mitochondria are organelles found in cells that are responsible for producing energy. They are believed to have originated from a #singlecell-ed organism and are made up of two membranes. They contain their own genetic material, called #mtDNA, which is made up of 16569 nucleotide base pairs. mtDNA mutations can lead to mitochondrial dysfunction, which can cause #onco-genic events, such as #tumor cell reprogramming and metabolic shifts. #Mitoepigenetics is the study of how #epigenetics mechanisms regulate mtDNA transcription and replication, and it is believed to be involved in cancer progression.

The interconnection between #carcinogenesis (the development of cancer) and mitochondria (the energy-producing organelles in cells) was first proposed in 1973. Since then, there have been many studies done on this topic, using DNA scanning technologies to detect mutations and deletions. Mitochondrial DNA (mtDNA) is beneficial for carcinogenic studies because it consists of 37 genes with no introns, meaning most mutations will occur in coding regions. Additionally, mtDNA has a small size, is easy to extract, has no genetic rearrangements, and has fast mutation rates, which makes it useful for molecular research. It also has a high copy number, meaning only minimal #tissue samples are needed for analysis. Large-scale deletions are commonly known to be responsible for mitochondrial diseases, and are thought to be the cause of various diseases and cancers.

Two types of mtDNA deletions, 3.4 kb and 4977 bp are associated with various types of cancer. The 3.4 kb deletion was patented by Parr et al. [97] and is used to detect cancer in individuals. It is also used to determine different #prostate tissue types, either benign, malignant, or proximal to malignant [100]. The 4977 bp deletion is primarily associated with #aging and is a common deletion with missing mtDNA nucleotide sequences starting at 8470 to 13447 np [106]. It has been studied in various types of cancer, such as #breastcancer, #colorectal, gastric, hepatocellular, and #brain tumors, and is thought to be associated with external environmental factors, genetic predisposition, and ethnicity.

The text is discussing different types of deletions in mtDNA (mitochondrial DNA) that are associated with cancer. The 5.1.3 section is talking about the 3895 bp deletion, which was first observed in 1991 in two patients with progressive external #ophthalmoplegia. It was then found to be 10 times less frequent than the 4977 bp deletion. A study involving 104 age-matched subjects showed that the 3895 bp deletion was more frequent in those with usually sun-exposed skin and nonmelanoma skin cancer. The 4576 bp deletion was then discussed, which was found to be an indicator for breast cancer in a study involving 39 breast cancer patients. The 4576 bp deletion was not found in 23 normal patients without breast cancer. The text then moves on to discuss mtDNA copy number, which is the amount of mtDNA in each cell. It is suggested that mtDNA copy number changes may lead to mitochondrial instability and regulate energy metabolism, which can initiate #tumorigenesis. Studies have also shown that mtDNA copy number changes can be used as a predictive biomarker for #chemotherapy response.

Cell-free mtDNA (cf-mtDNA) is a type of mitochondrial DNA that is released into the #blood circulation due to disruption of the normal mitochondrial life cycle. It is believed to activate the Toll-like receptor 9 (TLR9) pathway, which can cause #inflammation and potentially lead to cancer. It has been used to diagnose cancer and sepsis, and as a biomarker for metabolic syndrome and predicting the risk of future diabetes. It is also being studied as a #noninvasive liquid #biopsy for cancer, as higher levels of cf-mtDNA have been found in cancer patients compared to healthy controls. Research is being conducted to find the potential link between cf-mtDNA and various cancers, as it is a preferable biomarker due to its higher mtDNA copy number, simpler structure, and shorter length.

Mitochondrial Microsatellite Instability (#mtMSI) is a type of genetic mutation that occurs in the mitochondrial genome. It is caused by short tandem repeats (mononucleotide or dinucleotide) of 1 to 6 base pairs that are scattered throughout the mitochondrial genome. These variations can lead to frameshift mutations, which can be caused by DNA polymerase γ, an enzyme that is responsible for oxidative damage. Mammalian mitochondria also have an inefficient mismatch repair system, which can lead to mtMSI formation. The most commonly reported mtMSI is located in the D-loop region, which is a mutational hotspot in primary tumors. It is a highly polymorphic homopolymeric C stretch, which is involved in R-loop formation, a stable RNA-DNA hybrid that triggers mtDNA replication. D310 alteration has been suggested as a new cancer detection tool and a potential early premalignant cancer marker. Another potential marker is D16184, which is located in the hypervariable region I and is involved in mtDNA biogenesis. Studies have reported the presence of D16184 in various cancer types, such as gastric and endometrial carcinoma. Somatic mtDNA alterations have also been correlated to cancer, with evidence showing that mtDNA changes can contribute to the development or progression of cancer. One example of a somatic mtDNA alteration is A12308G, which is located in the variable loop next to the anticodon stem of tRNA Leu (CUN). This alteration has been suggested as a potential diagnostic tool for #colorectalcancer and as a risk factor for prostate and #renalcancer. A10398G has also been studied in relation to cancer, although the results have been conflicting.

Mitochondrial biomarkers are molecules that can be used to detect cancer in its early stages. A commercial kit (PCMT) has been developed to help with this detection. However, even if cancer is detected early, it can still be difficult to treat if the symptoms have not yet developed. Therefore, researchers are looking into gene therapy and other mitochondrial interventions as potential treatments for cancer. They can use current advancements in vitro mitochondrial intervention to identify the pathogenicity and therapeutic potential of a particular mtDNA mutation. One method proposed is to transfer artificial healthy mitochondria to remove damaged mtDNA without genetic manipulation. Other studies have looked at the levels of mtDNA biomarkers in cancerous and non-cancerous samples, as well as the levels of mtDNA methylation and mtRNA in cancerous tissues.

@explainpaper

@cancer

@mitochondria

@mito

@dna

@mtdna

@precisionmedicine

@diagnostics

@mtmsi

@aging

@Ophthalmoplegia

@Tumorigenesis

@Blood

@Inflammation

@Biopsy

@Chemotherapy

@Colorectalcancer

@Renalcancer

@Brain

@Breastcancer

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