Sea anemone study identifies potentially regenerative #stem_cells linked to conserved #genes.

#Nematostella #single_cell_genomics

https://phys.org/news/2024-08-sea-anemone-potentially-regenerative-stem.html

The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#content

For #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.

For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look!

The search for i-cells: Andreas Denner and team #TechnauLab characterise a putative stem cell population in the sea anemone Nematostella vectensis.

preLight by Isabella Cisneros which includes an author response! 👀

#preLight 👉 https://prelights.biologists.com/highlights/nanos2-cells-give-rise-to-germline-and-somatic-lineages-in-the-sea-anemone-nematostella-vectensis/

#cnidarian #StemCells #multipotent #nematostella #pluripotent #DevBio #CellBiology

New #Nematostella single-cell reference atlas, from Alison Cole and the Technau lab https://www.researchsquare.com/article/rs-3854371/v1 #cnidaria #singleCell #biology

In collaboration with Alison Cole and Ulrich Technau we also mapped the peptidergic #connectome of #Nematostella, by linking peptide-expressing to receptor-expressing cells.
In #Cnidaria, tissues are extensively connected via #neuropeptide signalling.
#neuroscience

The 31 new deorphanized #neuropeptide #GPCRs from #Nematostella and the #phylogenetic trees also allowed us to predict the ligand for many receptors across #cnidarians. We hope that cnidarian researchers will functionally characterising these e.g. by #CRISPR, as the Houliston lab has done for the MIH receptor.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000614
#evolution #neuroscience

To get a comprehensive list of #neuropeptides, we combined #bioinformatic screening and mass spectrometry in collaboration with Amanda Kieswetter and Liesbet Temmerman at KU Leuven. We found 15 new proneuropeptides and confirmed the endogenous processing (cleavage, amidation etc) of many of them. #Nematostella has at least 33 neuropeptide precursors.
#cnidaria #neuroscience

In our new preprint we characterise neuropeptide signalling in the cnidarian #Nematostella.
https://www.biorxiv.org/content/10.1101/2023.07.03.547448v1
Daniel Thiel and Luis Yanez-Guerra screened 64 neuropeptides against 161 G-protein coupled receptors (#GPCR) and found activating peptide ligands for 31 receptors.
#cnidaria #neuropeptide #evolution #neuroscience

Starlet #SeaAnemones found to be capable of associative learning https://phys.org/news/2023-04-starlet-sea-anemones-capable-associative.html

Associative learning in the cnidarian #Nematostella vectensis https://www.pnas.org/doi/10.1073/pnas.2220685120

#Cnidaria phylum do not have a brain. They have a network of #nerves but no known organ that processes neural activity.

Single #gene causes #stinging #cell to lose its sting.

#cniderians #Nematostella #NvSox2 #nematocysts #CRISPR

https://phys.org/news/2023-02-gene-cell.html

#Microbiome plasticity in the #SeaAnemone #Nematostella depends mostly on changes in ambient water temperature, while host genotypes differ in their microbial plasticity, reflecting different abilities to cope with a changing #environment #PLOSBiology https://plos.io/3j7WAOa

#Microbiome plasticity in the #SeaAnemone #Nematostella depends mostly on changes in ambient water temperature, while host genotypes differ in their microbial plasticity, reflecting different abilities to cope with a changing #environment #PLOSBiology https://plos.io/3j7WAOa

#Microbiome plasticity in the #SeaAnemone #Nematostella depends mostly on changes in ambient water temperature, while host genotypes differ in their microbial plasticity, reflecting different abilities to cope with a changing #environment #PLOSBiology https://plos.io/3j7WAOa

Our work on the evolution of DEG/ENaC channels and how one of them controls acid-based discharge of cnidocysts in #Nematostella is finally published. Great collaboration with Stefan Gründer (RWTH Aachen) and his group. Thanks to all the authors for their hard work in this journey (almost four years).

https://www.nature.com/articles/s42003-022-04399-1

Kathrin Garschall tattoos a #star in the #starlet sea anemone #nematostella
Using the fantastic spinning disk microscope at the Sars Centre!

Postdoc in #marinebiology #molecularecology and #neuroscience. Futur european PI in a very instable biosphere.

Oren Levy Lab
Lior Appelbaum Lab

Investigate #circadianrhythm, #clock, #sleep, #CellStress in #cnidarian symbiotic or not, in their normal state or under environmental pressure.

#Behavior #CellularBiology #Imaging #MolecularBiology #Omics #Field
#Nematostella #Exaiptasia #Cassiopea #StonyCorals

Posting about sciences and climate crisis awarness.

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