Nous relayons, via le site de l'association Emilys la question écrite au gouvernement portée par Loïc Prud'hommme sur le dossier #prion à l'#INRAE.
A SUD-RE attendons une suite positive à l'alerte au Comité d'Ethique en mars, suite à l'interprétation détournée de son avis de fin 2023. Ce qui contrarie le recensement prévention nécessaire de toutes les personnes ayant travaillé dans les équipes concernées.
Espérons enfin une avancée sur ce dossier !
TMED9 mediates export of misfolded #prion proteins from the ER. This study shows that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @PLOSBiology https://plos.io/44kURu5
‘Don’t call it zombie deer disease’: scientists warn of ‘global crisis’ as infections spread across the US https://www.theguardian.com/environment/2025/mar/20/chronic-wasting-disease-spread-zombie-deer-global-us-aoe?CMP=Share_iOSApp_Other Another #Prion disease. Other prions have caused disease in cannibalism, and crossed between species where affected individuals are fed to other animals. Affected deer will be in the human food-chain.
Alerte commune du Comité d’Ethique (CCNE) par nos syndicats SUD Recherche et Education suite à l’interprétation détournée par le #MESR de l’avis de novembre 23 concernant le dossier #prion
Comment expliquer l'enlisement progressif depuis 5 années de ce dossier douloureux par la direction du ministère , sans y voir une conséquence d'un conflit d'intérêt doublé d'un déni de responsabilité ?
Nouvelle relance de la DG #INRAE sur l'enlisement du dossier #prion infectieux : nous attendons toujours des réponses aux questions de prévention portées en F3SCT de novembre dernier...
Avent d'exercer notre devoir d'alerte auprès du Comité Consultatif National d'Ethique (CCNE), pour dénoncer l'interprétation détournée du #MESR de l'avis sur le suivi des agents ayant travaillé dans les équipes concernées depuis le début des années 2000.
@Shanmonster #PrionDisease #CWD #prion
Prediction: As the mis-folded protein (prion) contamination spreads, it is inevitable that it will contaminate lands used to graze Bison, Cows, Sheep, Goats, Pigs and Boar.
In time (not all that much time) all of these will cease being foodstuffs in the United States.
In decades ahead this implies that Beef, Lamb, Pork and Goat, along with Bison, Deer, Elk, and other cervids will cease being food in North America, and Scandinavia.
Let that sink in.
@Shanmonster #PrionDisease #CWD #prion
Extent of Chronic Waisting disease updated to February 10, 2025 in North America.
https://www.usgs.gov/centers/nwhc/science/expanding-distribution-chronic-wasting-disease
Save the data & graphics before they disappear.
CWD is now in 35 States, 4 Canadian Provinces, Norway, Sweden and Finland. And in captive cervids in most of those, plus Quebec and South Korea.
The major transmission route is fecal-oral. I.e. fecal contaminated land. And once contaminated the land can transmit the disease for 1,000+ years.
Chronic wasting disease detected in #Georgia #deer for the first time.
https://phys.org/news/2025-01-chronic-disease-georgia-deer.html
A lire les échanges de fin 2024, en F3SCT, l'enlisement du dossier #prion infectieux perdure au MESR.
Il y a pourtant urgence à appliquer les préconisations de l'expertise qui date de... janvier 2022 !
Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for #prion disease that extends lifespan by about 50 percent in a mouse model of the fatal #neurodegenerative condition.
#Neuroscience #Genetics #sflorg
https://www.sflorg.com/2025/01/ns01142501.html
Protein aggregation is typical of various #neurodegenerative diseases such as #Alzheimer’s, #Parkinson’s and #prion diseases such as #Creutzfeld-Jakob disease.
#Neuroscience #sflorg
https://www.sflorg.com/2025/01/ns01062502.html
Postdoctoral Fellow - cell biology of prion infection
University of Calgary
Come join our dynamic team as a #postdoc fellow to study the impact of #prion infection on endosomal transport and cholesterol metabolism.
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-postdoctoral-fellow-cell-biology-of-prion-infection/?feed_id=83712...
https://jobrxiv.org/job/university-of-calgary-27778-postdoctoral-fellow-cell-biology-of-prion-infection/?feed_id=83712
A few years ago an attempt was made to extrapolate success in identifying #Prions as a #Pathogen in Bovine Spongiform Encephalopathy to other #NeuroDegenerative conditions Problem is that much of papers on molecular basis of #Prion #Diseases are probably #Fake #Science.
With only an inaugural dissertation (1 year) but claiming to had gained a PhD. from Abteilung für #NeuroPathologie (#Freiburg) Adriano #Aguzzi became a lurker at conferences while writing papers on the things as #Prion diseases now found to be problematic and possibly #Fake
Postdoctoral Fellow - cell biology of prion infection
University of Calgary
Come join our dynamic team as a #postdoc fellow to study the impact of #prion infection on endosomal transport and cholesterol metabolism.
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-postdoctoral-fellow-cell-biology-of-prion-infection/?feed_id=79197...
https://jobrxiv.org/job/university-of-calgary-27778-postdoctoral-fellow-cell-biology-of-prion-infection/?feed_id=79197
Postdoctoral Fellow - cell biology of prion infection
University of Calgary
Come join our dynamic team as a #postdoc fellow to study the impact of #prion infection on endosomal transport and cholesterol metabolism.
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-postdoctoral-fellow-cell-biology-of-prion-infection/?feed_id=78819...
https://jobrxiv.org/job/university-of-calgary-27778-postdoctoral-fellow-cell-biology-of-prion-infection/?feed_id=78819
Postdoctoral Fellow - cell biology of prion infection
University of Calgary
Come join our dynamic team as a #postdoc fellow to study the impact of #prion infection on endosomal transport and cholesterol metabolism.
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-postdoctoral-fellow-cell-biology-of-prion-infection/?feed_id=77356...
https://jobrxiv.org/job/university-of-calgary-27778-postdoctoral-fellow-cell-biology-of-prion-infection/?feed_id=77356
#Norwegian #moose #CWD induces clinical #disease and #neuroinvasion in gene-targeted mice expressing cervid S138N #prion #protein https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012350
Our study indicates that neuroinvasion of Norwegian moose prions can occur without, or only very limited, replication in the spleen, an unprecedented finding for CWD.
#Prion-Proteine bilden in den Zellen von Säugetieren dynamische Kondensate – in Froschzellen jedoch nicht. Dahinter steckt wohl eine spezielle #Protein-Domäne, wie ein Team von der @ruhr-uni-bochum.de verkündet. Anne-Christine Schmidt erzählt uns mehr darüber: https://www.laborjournal.de/editorials/3030.php
