Doctor Steven Murphy gives an excellent perspective and case examples ( #rapamycin ) in a recent post. Worth a read for anyone curious about how longevity docs actually make decisions when faced with incomplete evidence. 🧪🩺💊 substack.com/home/post/…
#Rapamycin
Anti-ageing drug rapamycin may extend life almost as effectively as restricting calories – our new research
#Health #Rapamycin #AntiAgeing #Longevity #DietMimics #CalorieRestriction #LifeExtension #AgeingResearch #Metformin #HealthSpan #ScientificResearch
https://the-14.com/anti-ageing-drug-rapamycin-may-extend-life-almost-as-effectively-as-restricting-calories-our-new-research/
New 30% mouse lifespan extension paper just dropped!
Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.
Read more here: https://andrewsteele.co.uk/blog/2025/05/rapamycin-trametinib-cocktail-lifespan-mice/
Peeps with long Covid who live in and around NYC
Mount Sinai is taking applications for a long covid clinical trial using low-dose rapamycin.
#LongCovid @longcovid #rapamycin #Sirolimus #NYC #NY #NJ #CT
4.) Is there currently any evidence of efficacy of any of the proposed "#anti-aging drugs" and interventions in human aging? E.g. #rapamycin, #metformin #resveratrol but also #reprogramming, #rejuvenation, #caloric restriction and others? In other words, is there a shortcut to health and eternal life? Spoiler: you might not like the answer... Moreover, some of these might even have negative effects on other health-beneficial interventions, e.g. the potential dampening of exercise training adaptation by metformin, resveratrol or rapamycin.
5.) We discuss all of the known factors for which solid data and proof for an impact on human health, the aging process, #morbidity (risk for a disease), #mortality (risk of premature death) and life expectancy exist. The good news: only around 20% (or even as low as 10%) of our aging trajectory is determined by our genes – this means that to a large majority, we can influence this ourselves! Some can be done on the individual level, first and foremost by physical activity, but also #sleep, #nutrition, #stress, social interactions and more. Others will have to be addressed on the societal/political level, e.g. #socioeconomic disparities or access to quality (and affordable) health care. Lastly, there are factors such as anthropogenic #climatechange or #pollution (e.g. air pollution or #microplastics) that we have to solve on a global scale.
2/4
#FYI #rapamycin #alzheimers #pharmacokinetics
"Rapamycin, an mTOR inhibitor used clinically for immunosuppression, shows promise for repurposing in age-related disorders including Alzheimer's disease (AD).
This open-label pilot study investigated the pharmacokinetic properties of weekly oral rapamycin in [...] early-stage AD.
Findings [...] support fixed-dose regimens in future trials."
https://biologists.social/@medrxivpreprint/114188319062962075
Intriguing bit in this video about ketamine + rapamycin improving heat tolerance (this is not a recommendation - I don't know enough about it)
https://youtu.be/9Z4Eg1dtyOc?si=EXVnqvV6-vd7rqEj&t=2188
#thermoregulation #physiology #ketamine #rapamycin #HeatTolerance #neuroscience #POTS
today I watched:
Brain Repair: The Ketamine Combo Treatment for Depression and Chronic Pain
https://youtu.be/9Z4Eg1dtyOc?si=MPMcrFYYj2De6u9Y
Very interesting and pretty technical. I will have to re-watch.
[37:00] - #POTS #MCAS #hypermobility #LongCovid
#2dayIwatched #ChronicPain #psychiatry #neuroscience #rapamycin #ketamine
Wie dieser Mann versucht, den #Tod zu umgehen
Softwaremillionär Bryan Johnson will das #Altern besiegen. Sein Ansatz beinhaltet eine rigorose Überwachung seiner Gesundheit und eine Kombination aus Ernährung, Bewegung, Schlafmanagement sowie experimentellen Therapien wie #Rapamycin, Licht-Therapie und sogar #Plasmatherapie.
The role of #TOR #signaling in enhancing #graft success and #crop vigor.
https://phys.org/news/2024-04-role-tor-graft-success-crop.html
How a cheap, generic drug became a darling of longevity enthusiasts
#rapamycin has gained a large following thanks to longevity researchers and celebrity doctors who, citing #animal #studies, contend that rapamycin could be a game changer in the quest to fend off age-related diseases.
The drug is going mainstream as an anti-aging treatment, even though rapamycin’s 🔹regulatory approval is for treating transplant patients. 🔹
♦️There is no evidence that it can extend human life.♦️
Researchers have found that rapamycin can modify a kind of cellular communications system that gives cells certain directions
— to grow when the body has plenty of food and to slow down when nutrients are scarce.
The drug can dial down the signal to grow, causing cells to clear out accumulated junk and allowing them to run more efficiently.
Despite the buzz surrounding the drug, it is unlikely that the Food and Drug Administration will ever approve it for longevity.
🔸The agency doesn’t consider aging to be a disease, 🔸and rapamycin’s generic status means 👉there’s little financial incentive to run expensive clinical trials to test it on age-related afflictions.
https://www.washingtonpost.com/business/2024/03/15/rapamycin-longevity-drug/
(Potential) Anti-Aging drug derived from yeast found on Easter Island, how Sci-fi is that?!
review article from 2015:
mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455918/
All the #rapamycin trials in the news this month! This is looking at using it in ME/CFS: https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/
The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!
His Rare Disease's Cure Was Sitting on the Pharmacy Shelf
https://www.medscape.com/viewarticle/997734?src=rss #CastlemanDisease #idiopathic #multicentric #rapamycin #IL6blocker #tocilizumab
#Rapamycin and Muscle Growth: A Review of the Glass Lab's use of Rapamycin to Reverse #Sarcopenia and Anabolic Resistance
Fascinating study on how #rapamycin extends longevity in dogs. #aging #longevity https://www.the-scientist.com/news-opinion/aging-dogs-provide-insights-for-human-longevity-71223
A study from 2019 "by UT Health San Antonio and collaborating institutions shows age-related decreases in blood flow to the brain and memory loss can be modified with the drug rapamycin.
This finding, if furthered, holds implications for aging in general and perhaps offers an avenue to prevent Alzheimer’s dementia in some people, said research first author Candice Van Skike, Ph.D., of UT Health San Antonio."
https://news.uthscsa.edu/study-rapamycin-prevents-age-related-brain-vascular-deterioration/
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