#autophagy #longevity #fasting #rapamycin #mTOR #BlueZones #healthylifestyle #healthyaging #podcast #wellnessguide #wellnessvibes #biohack #biohacking #biohacker #biohackingsecrets #biohackers #biohacks #health https://mastodon.social/@biohackingpathway/115205901317949853
#mTOR
Unlocking mTOR: Intermittent fasting, coffee, and exercise are keys. During exercise, mTOR is suppressed, but after? It springs back!
Follow @biohackingpathway for more
#mTOR #intermittentfasting #coffee #exercise #health #fitness #longevity #biohacking
“…scientists made a surprising discovery: caffeine doesn’t act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.” #DNA #epigenetics #coffee #ISOGG #geneadons #caffeine #AMPK #MTOR
@unibremen And I saw you also signed More Than Our Rank recently. Well done!
https://inorms.net/more-than-our-rank/
`Here, we show that decreasing the activity of the #mTOR signaling pathway induces human pluripotent stem cells... & blastoids to enter a dormant state with limited proliferation, developmental progression, & capacity to attach to endometrial cells..similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage & is reversible..The pacing of human #blastocyst development has potential implications for reproductive therapies`
review article from 2015:
mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455918/
#Lysosomes prove to be quick-change artists with respect to #nutrient availability in the #cell.
https://phys.org/news/2023-10-lysosomes-quick-change-artists-respect-nutrient.html
As of today, all More Than Our Rank signatories that appear in the Leiden Ranking are highlighted on the ranking website. Read more about this partnership between @INORMS_REG and @cwts in our @leidenmadtrics blog post https://www.leidenmadtrics.nl/articles/the-leiden-ranking-goes-beyond-ranking @lizziegadd @LudoWaltman #LeidenRanking #MoreThanOurRank #MTOR
Investigating the link between #iron deficiency and regulation of #cell_growth.
#evolution #anabolism #mTOR #KDM3B #LAT3, #RAPTOR
https://phys.org/news/2023-09-link-iron-deficiency-cell-growth.html
New paper! Great collaboration between our group and the @mz at @biozentrum @unibasel - supported by a Sinergia grant of the @snsf_ch.
Aberrant #proteostasis (balance between protein synthesis and degradation, centrally regulated by #mTOR) and mitochondrial dysfunction are two of the most prominent and reproducible processes associated with #aging in skeletal #muscle (and other tissues).
1/2
How an ultra-sensitive on-off #switch helps #axolotls regrow #limbs.
#sensing #signalling #mTOR #translatome #tissue_regeneration
https://phys.org/news/2023-07-ultra-sensitive-on-off-axolotls-regrow-limbs.html
Did you know that recordings of our first #MoreThanOurRank #MTOR community calls are now available for viewing on our website? https://inorms.net/more-than-our-rank-community-calls/
INORMS Research Evaluation Group invites you to join our #MoreThanOurRank Community Calls: https://inorms.net/more-than-our-rank-community-calls
We organise two calls, March 24 and April 17, 2023, in different time zones to ensure opportunities for community participation worldwide.
#MTOR is a response to some of the problematic effects of the global university rankings. By participating academic institutions show commitment to responsible assessment and acknowledge a broad and diverse definition of institutional success.
#introduction: The INORMS Research Evaluation Group #INORMS_REG members are representing #ResearchManagementAssociations #RMA from across the globe. Our focus is #ResponsibleResearchEvaluation.
The latest #INORMS_REG initiatives are #SCOPE: A step-by-step guide for evaluating research responsibly, and #MoreThanOurRank #MTOR: A response to some of the problematic effects of the #GlobalUniversityRankings.
#INORMS_REG is chaired by @lizziegadd We also have a website https://inorms.net/research-evaluation-group/
#TSC2 regulates #tumor susceptibility to TRAIL-mediated T #lymphocyte killing by orchestrating #mTOR signaling
Daniel Peeper and colleagues, The Oncode institute
https://www.embopress.org/doi/full/10.15252/embj.2022111614
🧬MCBG Program Faculty Highlight 2021-2022🧬
Dr. Christian Sell
Department of Biochemistry & Molecular Biology, Drexel University College of Medicine
#aging #research #mTor #lifespan #cellbiology #molecularbiology #genetics
Saha, Pearce &co show that WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport. #openaccess thanks to @Co_Biologists' #Readandpublish agreement with University of California: https://journals.biologists.com/jcs/article/135/23/jcs260313/285827/WNK1-is-a-chloride-stimulated-scaffold-that
#cellbiology #science #sciencemastodon #openscience #research #mTOR
"Here, we have identified the mTOR pathway as a major determinant of chemosensitivity through a genome-wide CRISPR knockout screen. We show that mTOR inhibition causally leads to the emergence of a reversible drug-tolerant persister population with a senescence phenotype, which is dependent on autophagy and G2/M cell cycle arrest for survival."
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