Lmst

I rarely splice sitting on the ground but this afternoon I didn't feel like carrying the table to the chamber.

#splicing #fibre #FibreBroadband #altnet #altnets

A photograph taken by someone sitting on the ground, in front of them is a fibre splicing machine with an orange lid. Behind that device is the fibre enclosure with many trays of fibre. To the right is a fibre cleaver and the splicing map. On the left is the lid of the fibre enclosure. Behind all of that is a wooden bar fence and far in the distance are trees and blue sky.

A cold North East wind today (over 20kts) so we did a quick trip to our shipping container, then Jane has been #splicing the first #dyneema main mast chainplate loop (much harder splicing 12mm than 9mm).
After some writing for work I've been working on wiring diagrams (learning and using #QElectroTech). I like that I can pretty easily create basic custom elements such as our Batteries, #Victron boxes etc.

#SilentSunday #Splicing #RuralBroadband #Altnet #Altnets #UK #FibreBroadband #FTTP

And to follow up.. Tuesday evening (not quite such a late one).

#Splicing #fibre #fiber #altnet #altnets #RuralBroadband

A photo of several large fields dropping slightly revealing a hill in the distance. Blue sky and green grass is abundant.
Bottom right of the shot is a chamber lid with some fibre equipment on the top. Orange tubes come from the equipment.

Worked into the early evening .. but got to see this from my work site.

#Splicing #altnet #altnets #fibre #FibreSplicing #sunset #uk #SilentMonday #RuralBroadband #Rural #RuralEngland

A wooden table in a large field surrounded by forest. A golden sunset is in the sky. Some work equipment is on the table.

Is the #World Ready? - #2025 #SolarStorm : Medium

#MIT #Biologists #Discover a new type of control over #RNA #Splicing : MIT

#Physicists capture a strange #Fractal ‘#Butterfly’ for the first time : New Sci

Check our latest #KnowledgeLinks

https://knowledgezone.co.in/resources/bookmarks

Biologists discover a new type of control over #RNA #splicing

#spliceosome #U1 #snRNA #LUC7

https://phys.org/news/2025-02-biologists-rna-splicing.html

Cheap, low-effort, perfect filament splicing method

https://toobnix.org/videos/watch/b1d3fcc7-3067-4cb8-84b7-5e19dc340f36

Die Endokrinologin @AltieriBarbara @EndoWue @Uniklinikum_Wue wurde vom @BZKF_bayern ins Young-Scientist-Fellowship-Programm 2025 aufgenommen und erhält 100.000 Euro für die Erforschung neuer Therapieansätze beim Nebennierenkrebs #RNA #Splicing #SF3B1
https://nachrichten.idw-online.de/2024/12/05/100-000-euro-fuer-neue-therapieansaetze-bei-nebennierenkrebs

Undersea Cable Repair https://hackaday.com/2024/07/30/undersea-cable-repair/ #Engineering #OriginalArt #underwater #Featured #internet #splicing #cable #ocean #boat

A 6 months internship (M2) is open in our laboratory for January 2025 to work on #RNA, the genetics and biochemistry of its #splicing, export from the nucleus and degradation in the cytoplasm. With new tools and exciting preliminary results in #Cryptococcus neoformans, an intron-rich and fascinating human #fungal pathogen.

https://cosminribo.eu/posts/2024-07-m2topic/

"Most importantly, by proving that the evolutionarily-conserved RNA core of splicing machines can recognize small molecules specifically, our work provides a solid basis for the rational design of splicing modulators not only against bacterial and organellar introns, but also against the human spliceosome, which is a validated drug target for the treatment of congenital diseases and cancers." #spliceosome #splicing #intron #introns #transcription #ribonucleicAcid #RNA

https://www.nature.com/articles/s41467-024-48697-0

#Genes spatially organize for efficient #mRNA #splicing, study shows.

#nuclear_speckles

https://phys.org/news/2024-05-genes-spatially-efficient-mrna-splicing.html

Alternative #splicing and #transcription factor interplay in #blood_orange #anthocyanin #biosynthesis.

#agriculture #RUBY1 #MBW #CsTT8 #signalling

https://phys.org/news/2024-03-alternative-splicing-transcription-factor-interplay.html

Researchers study role of #post_transcriptional #splicing in #plant response to #light.

#spliceosome #AtPRMT5 #photosynthesis

https://phys.org/news/2024-02-role-transcriptional-splicing-response.html

Hong Cheng and collaborators identify #SAP30BP as a novel critical activator of #CDK11-#CyclinL complexes, required of regulation of pre-mRNA #splicing in cells
https://www.embopress.org/doi/full/10.15252/embj.2023114051

If you wonder what splice isoforms exist for your gene(s) of interest, or if you are interested in exploring tissue/cancer-specific splicing, we have a new tool for that.

#RNA #splicing #cancer

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad1043/7416386?login=false

Nice work on #chromatin and #splicing by the lab of Gil Ast:

Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation

Mol Cell,
https://doi.org/10.1016/j.molcel.2023.10.003

Julia Salzman from Stanford
http://salzmanlab.stanford.edu/

now explaining
SPLASH: Statistically Primary aLignment Agnostic Sequence Homing

We want to rapidly survey large #genomic areas, for regulatory sites, #splicing, etc. How do we look at sequencing data today? Through a lens of alignment with reference genomes. This can fail (e.g. cancer cells with shattered genomes, #V(D)J #recombination in immune cells)

Her metaphor: we need ground penetrating radar for #genomics

#CSSingleCells23

1/2

We are pleased to announce that registration to this year's annual meeting in memory of Prof. Yossi Sperling is now open, at the link below. The meeting will take place in the Lopatie Hall at the Weizmann Institute on 16 Oct, 2023. We will be celebrating local RNA science, and enjoy contributions from our two wonderful keynote speakers for this year - Marvin Tannenabum and Christin Mayr (see attached poster)

#RNA #mRNA #lncRNA #translation #splicing #transcription

https://erez.weizmann.ac.il/apx/r/ws1/101/101/?P101_PKNS_CODE=2604

#Splicing

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