Unser Heft 11/2024 ist draußen!

Mit großem Special "Stammzell-#Forschung"

Außerdem:
- #Corona-#Impfstoff;
- Kontroverse #UMAP-Plots;
- #Forschungskandale;
- #Krebsforschung;
- #lncRNA;
- #Protein-#Sequenzierung;
- #Antibiotika-Inkubator
- u.v.m.

Das ganze Heft online: https://www.laborjournal.de/rubric/aktuell/index.php

Expanding and Enriching the LncRNA Gene–Disease Landscape Using the GeneCaRNA Database. https://doi.org/10.3390/biomedicines12061305 #NonCodingRna #LongNonCodingRna #HumanNoncodingRna #Ncrna #Lncrna

I’m happy to share our preprint
“Flawed machine-learning confounds coding sequence annotation“
https://doi.org/10.1101/2024.05.16.594598
A collaboration with @OtagoBiochemist and @plantandfood scientists @mikblacknz @TingHsuanTHC #Genomics #Bioinformatics #ncRNA #lncRNA #protein 1/n

A new tool for #plant long non-coding #RNA identification.

#lncRNA #Plant_LncPipe

https://phys.org/news/2024-05-tool-coding-rna-identification.html

Things aren’t always what they seem! Three #preprints together reveal that the lncRNA ivory and its microRNA mir-193, not cortex, drive melanic scale identity in butterflies 🦋

Brilliant preLight from Isabella Cisneros! 🤩

#preLight 👉 https://prelights.biologists.com/highlights/a-long-non-coding-rna-at-the-cortex-locus-controls-adaptive-colouration-in-butterflies-the-ivory-lncrna-regulates-seasonal-color-patterns-in-buckeye-butterflies-a-micro-rna-drives-a-100-million-year-2/

#biology #butterfly #color #patterning #lncrna #mirna #rna

New insights on the #transcriptional #regulation of #seed #germination.

#lncRNA #arabidposis

https://phys.org/news/2024-03-insights-transcriptional-seed-germination.html

#CRISPRlnc: New #lncRNA-specific #SgRNA design method proposed.

https://phys.org/news/2024-03-crisprlnc-lncrna-specific-sgrna-method.html

Plant shade avoidance syndrome is controlled by APOLO #lncRNA regulation of #auxin-related genes in #Arabidopsis
Federico Ariel and colleagues
https://www.embopress.org/doi/full/10.15252/embj.2023113941

An interesting finding from Tim Bredy, Rob Spitale & others:
lncRNAs localize to synapses, regulate synaptic activity and behavior!
#lncRNA #RNA #synapse

https://www.nature.com/articles/s41467-023-43535-1

🥳 Happy to share the publication of the last part of Thomas Roule's Ph.D. at IPS2 on the role of ARES #lncRNA 🧬 in the modulation of Arabidopsis 🌱 root architecture. https://doi.org/10.1002/iub.2761

A great collaboration with the group of Federico Ariel 🧪

Examining the role of #methylation in #vernalization and the #photoperiod pathway: A potential #flowering #regulator?

#plants #lncRNAs #hormones #lncRNA

https://phys.org/news/2023-10-role-methylation-vernalization-photoperiod-pathway.html

MCBG Seminar 🧬🧬🧬

Thursday, October 12, 2023, 1 PM

Nima Sarfaraz, MCBG PhD Candidate
Advisor: Dr. Michael Bouchard
Department of Biochemistry & Molecular Biology
Drexel University College of Medicine

Characterization of Hepatocellular Carcinoma-Dysregulated Long Non-Coding RNA FAM99A

#CancerBiology #CellBiology #lncRNA #BiomedicalScience

#Wheat's long #non_coding #RNAs unveiled: A leap in understanding grain #development.

#lncRNA #ssRNA_seq #agriculture #Triticum

https://phys.org/news/2023-10-wheat-non-coding-rnas-unveiled-grain.html

Cool story: xenografting of human #neurons into mouse #Alzheimers model resulted in their death by #necroptosis. This process involves #lncRNA MEG3, possibly via TNF inflammatory signaling. This study revealed human-specific vulnerability in AD.
#neuroscience
https://www.science.org/doi/10.1126/science.abp9556

Just Published!

Structure and Function of the H19 Long Non-coding RNA in Cancer

https://link.springer.com/chapter/10.1007/16833_2023_177

#Cancer #CancerResearch #lncRNA

Drexel MCBG Thesis Defense 🧬 🧬 🧬

Zahra Charania, MCBG, MS Candidate

Tuesday, August 8, 2023, 1:00 p.m. NCB, Room 11-101

Identifying conserved regions in lncRNA SChLAP1

Mentor: Dr. Srinivas Somarowthu
Drexel University College of Medicine, Department of Biochemistry and Molecular Biology

#GraduateStudent #GraduateStudies #BiomedicalScience #RNA #lncRNA #CellBiology #MolecularBiology #Biochemistry

#LncRNA NRON promotes #tumorigenesis by regulating #MDM2/#MDMX heterodimerization and enhancing their #ubiquitin-dependent degradation of multiple #tumorsuppressor proteins
Erwei Song, Man-Li Luo and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022112414

We are pleased to announce that registration to this year's annual meeting in memory of Prof. Yossi Sperling is now open, at the link below. The meeting will take place in the Lopatie Hall at the Weizmann Institute on 16 Oct, 2023. We will be celebrating local RNA science, and enjoy contributions from our two wonderful keynote speakers for this year - Marvin Tannenabum and Christin Mayr (see attached poster)

#RNA #mRNA #lncRNA #translation #splicing #transcription

https://erez.weizmann.ac.il/apx/r/ws1/101/101/?P101_PKNS_CODE=2604

LncRNA FLAIL affects alternative #splicing and represses flowering in #Arabidopsis

Sebastian Marquardt and coworkers identify #FLAIL as a trans-acting #lncRNA that targets the #spliceosome and regulates plant #flowering by promoting expression of the #laccase LAC8

https://www.embopress.org/doi/10.15252/embj.2022110921

A new paper from @wu_xuebing 's lab just published @Nature
"Noncoding translation mitigation"

https://www.nature.com/articles/s41586-023-05946-4

Here are my thoughts:
It is a very interesting paper, and important to anyone working on #translation, particularly from #ncRNAs, but not only.
In brief, they screened short sequences originating from #lncRNA or from non coding regions ( #UTR #intron) (and #mRNA CDS as control) which they fused to GFP at the C-term and looked at GFP expression level.
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