Lmst

#Synapses

🧠 #Neurons can communicate via a hidden network of #nanotubes, new study finds. Chang et al. (2025) show that dendritic nanotubes (DNTs) are #actin-based #dendrite-to-dendrite conduits transferring Ca²⁺ and molecular cargo (incl. #Aβ), rising before plaque deposition in mouse #cortex. This overlooked pathway may expand our view of neuronal communication beyond #synapses:

🌍 https://www.science.org/doi/10.1126/science.adr7403

#Neuroscience

🧠Wie Synapsen zusammenhalten 🤝

Diese Entdeckung hat ein Kölner Forschungsteam über die molekulare Architektur von Synapsen gemacht. Die Studie zeigt, dass das Protein Gephyrin im Gehirn flexible Filamente bildet und damit als wichtiger Baustein inhibitorischer Synapsen dient.

Mehr dazu▶️ https://uni.koeln/YAZEK

📰 https://www.nature.com/articles/s41467-025-63748-w

#uniköln #unicologne #Forschung #Synapsen #Gehirn #Neurologie #Research #Synapses #Brain #Neurology

Molekulare Strukturmodell des Gephyrin Proteinkomplexes auf grauem Hintergrund, mit farbigen Segmenten: gelb, blau, grau, rot und grün, die die Proteinuntereinheiten darstellen.

🧠 How Synapses Hold Together 🤝

This discovery was made by a Cologne-based research team studying the molecular architecture of synapses. The study shows that the protein gephrin forms flexible filaments in the brain, serving as an important building block of inhibitory synapses.

Read more ▶️ https://uni.koeln/PSVRY

📰The study was published in Nature Communications: https://www.nature.com/articles/s41467-025-63748-w

#uniköln #unicologne #Forschung #Synapsen #Gehirn #Neurologie #Research #Synapses #Brain #Neurology

Cryo-electron microscopy image of gephrin visualized in colored 3D structures.

🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.

🌍 https://doi.org/10.1101/2025.09.17.676728

#Neuroscience

Figure 1: Spontaneous synaptic and non-synaptic exocytosis along the axon.

Ah, the riveting tale of psychiatry's #metaphorical #brain babble, where #neurons are poets and #synapses sing 🎤. #Nature.com suggests upgrading your #browser because, apparently, without the latest CSS, you can't truly grasp the profound wisdom of metaphorical mush 💻🔍.
https://www.nature.com/articles/s41380-025-03053-6 #psychiatry #upgrade #HackerNews #ngated

Piangere non è un sintomo.
È il modo in cui il cervello riscrive se stesso.
Ogni lacrima contiene memoria, ormoni, riorganizzazione.
Ogni abbandono lascia una traccia nelle sinapsi.
Ogni emozione profonda… ci cambia per sempre.

Articolo completo sul blog

#michiyospace #neuroplasticità #emozioni #pianto #neuroscienze #lacrime #doloreemotivo #connessioni #sinapsi #abbandono #menteecorpo #connettoma

Crying is not a symptom.
It’s how the brain rewrites itself.
Every tear contains memory, hormones, reorganization.
Every abandonment leaves a trace in the synapses.
Every deep emotion… changes us forever.

Full article on the blog

#neuroplasticity #emotions #crying #neuroscience #tears #emotionalpain #connections #synapses #abandonment #mindandbody #connectome

One mechanism, three disorders: When the excitability margin in vCA1 neurons falls <5 mV, network oscillations replay emotional engrams → depression, schizophrenia, PTSD.
🔗 https://doi.org/10.31219/osf.io/e4cwb_v1

#Science #Neuroscience #Neurobiology #Neurophysiology #Brain #BrainHealth #MentalHealth #Psychiatry #Schizophrenia #Depression #PTSD #Hippocampus #Memory #Synapses #CognitiveScience #NeuralNetworks #OpenScience #FediSci #Preprint #AcademicChatter #AcademicTwitter #SciComm #Researchers #Research #OSF

Graphical abstract: progression from healthy green CA1 neuron (20 mV buffer) to orange (5 mV) to red (2 mV), with icons for stress, genetic risk, hot spots, drugs, nicotine, sugar, alleles, microplastics. At <5 mV, network oscillations replay emotional engrams, leading to depression, schizophrenia, or PTSD. Gradient bar from green to red shows ΔVmargin narrowing.

Improvisation graphique du mercredi. utilisation d'un motif se répétant en variation.
#dessin #graphisme #drawing #synapses

Dessin utilisant un motif se répétant en variations.

Our new research on cannabinoid signaling in cerebellar development and function is published in eNeuro.
#cannabinoid #cerebellum #Purkinje #DevelopmentalNeuroscience #endocannabinoid #indianauniversity #synapses #braindevelopment

https://www.eneuro.org/content/12/7/ENEURO.0400-24.2025

Molecular Glue of the Brain: Cell Adhesion Molecules and Synaptic Stability

#Neuroscience #BrainScience #Synapses #NeuronalCircuits #Neuroplasticity #ExcitatoryInhibitoryBalance #DendriticSpines #ExtracellularMatrix #Interneurons #CognitiveHealth #Neurobiology #BrainDevelopment #NeuralConnections #Neuropsychiatry #BrainFunction

https://youtube.com/shorts/dz-Wr8VAww0?feature=share

The #Brain stores #Memories primarily by strengthening or weakening the connections between neurons, called #Synapses.

This process, known as synaptic plasticity, allows neural circuits to be physically reshaped, forming robust pathways that encode learned information.

https://knowledgezone.co.in/posts/How-does-the-Brain-Store-Memory-678603b1a7e475eb5e304048

Exploring the Brain: A Journey Through Neuroimaging and Neural Dynamics

#BrainScience #Neuroimaging #Neuroscience #BrainHealth #Microglia #Synapses #Endocannabinoid #Neurochemistry #BrainArchitecture #Memory #Cognition #MoodRegulation #Neurotherapy #BrainConnectivity #MentalHealth #NeuroscienceExplained

https://youtube.com/shorts/JBEXN3VIQ5I?feature=share

Synaptic transmission is modulated by #neuropeptides in sensory systems & interneurons. This study shows that motor #synapses are also modulated by neuropeptidergic signaling, where lower ACh levels are compensated by upregulation of postsynaptic Ca2+ channels @PLOSBiology https://plos.io/4d6Ecgg

Autocrine and paracrine neuropeptidergic signaling at the Caenorhabditis elegans NMJ affects cholinergic transmission. The diagrams show the neuromuscular junction of C. elegans, with cholinergic and GABAergic motor neuron, as labeled, innervating dorsal and ventral muscle, respectively. Dyadic synapse of cholinergic neuron to GABAergic neuron and muscle. Note that the same innervation pattern exists from different sets of MNs, but with inverted topology (not represented in this graph). Also shown is the proprioceptive neuron DVA, that innervates cholinergic neurons along the ventral nerve cord (drawn more dorsal, for simplicity). Relevant ion channels and receptors are indicated on the left (NPR: neuropeptide receptor). The lefthand panel shows the situation in wild-type individuals. The righthand panel shows the situation in unc-31 (CAPS) or egl-3; aex-5 (pro-protein convertases, PCs) double mutants, where no mature neuropeptides are released or formed, thus the signaling steps induced by neuropeptides are absent.

How do diverse synapses in the brain organize their nanoarchitecture? This study uses #nanobodies & STED imaging to study the nanoarchitecture of thalamocortical & corticocortical #synapses, revealing distinct principles of synaptic nano-organization in the brain @PLOSBiology https://plos.io/3FY4vcd

Top left: Schematic of synaptic immunolabeling. Top right: Representative four-channel confocal images of L5 apical dendrite in 6 µm cryosections from Thy1-YFP-H mice. PSD-95 (magenta) and VGluT1 (yellow) were visualized with nanobodies conjugated to Abberior STAR 635P and Abberior STAR 542, respectively. Bassoon (cyan) was labeled using antibodies. Arrows indicate dendritic spines. Scale bar, 5 µm. Bottom: Model of trans-synaptic PSD-95/Bassoon nano-organization in VGluT1 + and VGluT2 + spines in basal (left) and apical (right) compartments of L5 neurons.

WRITER FUEL: Human brains take in sensory data at more than 1 billion bits per second, but only process that information at a measly 10 bits per second, new research has found.

https://www.limfic.com/2025/03/31/writer-fuelthe-human-brain-processes-thought-much-more-slowly-than-you-might-think/

#LimFic #LiminalFiction #WriterFuel #Writers #Authors #WritersofMastodon #StoryIdeas #HumanBrain #Synapses #Processing

Role of axo-axonic synapses among olfactory receptor neurons (ORNs) in odor decorrelation, mediated by metabotropic acetylcholine receptors:

"Nonlinear high-activity neuronal excitation enhances odor discrimination", Julia E. Manoim-Wolkovitz et al. 2025
https://www.cell.com/current-biology/fulltext/S0960-9822(25)00198-8

#neuroscience #Drosophila #AxoAxonicSynapses #synapses #olfaction

#Cellular structure without a #membrane: Researcher discusses how #synapses use #liquids to create functional separations.

#LLPS #membrane-less_organelles #neurotransmission

https://phys.org/news/2025-03-cellular-membrane-discusses-synapses-liquids.html

"The first synapse was visualized using electron microscopy in the mid–1950s, although parallel work and delicate egos make it difficult to determine with certainty the first researcher to actually see one." – Alexandra Balwit https://www.asimov.press/p/barcoding-brains

Neuroscientists are human after all.

#neuroscience #synapses #ElectronMicroscopy

Synapses in the fly brain learning and memory centre, the mushroom body:

"Quantitative characterization of the pattern of Brp clusters across multiple individuals revealed cell-type-dependent synapse heterogeneity and stereotypy. Furthermore, we discovered previously unidentified sub-compartmental synapse configuration and its regulation by cAMP signaling."

From:
"High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain", by Wu et al. (Tanimoto lab) 2025
https://www.biorxiv.org/content/10.1101/2024.12.02.626511v4

#neuroscience #Drosophila #MushroomBody #synapses