Beautiful ...and super interesting.
#cellAdhesion
Now published... and on the #BiophysJ cover!
Cell Adhesion Pattern Shows Conserved #Scalings under #Geometrical Control
Studying the relationship between the size and the #anatomy and #physiology of #living #organisms has proven useful in deciphering what the key physical constraints are that apply to them. For instance, total adhesive pad area is found to #scale like organism mass over a wide variety of animal species, possibly to resist against body weight.
In this study, we apply this approach at the cell scale to ask how large-scale geometrical constraints affect the organisation of #adhesion patches and the size of #cellSubstrate contact at different stages of the #cellSpreading process. Indeed, #cells, like many animals, adhere to their substrate. For that, they use specific protein complexes, called #focalAdhesions, which form patches often situated at the cell periphery.
cc @JonFouchard
Unveiling the Architect of Life: Exploring the Plasma Membrane
#CellAdhesion, #CellMembrane, #CellSignaling, #Communication, #Disease, #Homeostasis, #LipidByLayer, #Pathology, #PlasmaMembrane, #SelectivePermeability, #SemiPermeableMembrane, #UnitMembrane #CellBiology Composed primarily of lipids, proteins, and carbohydrates, the plasma membrane exhibits a dynamic and heterogeneous structure. Phospholipids, with their hydrophilic heads and hydrophobic tails, form the…
#FGF modulates cell adhesion to help salivary glands branch out
A Research Highlight showcasing new work from Ayan Ray & Philippe Soriano
Read the full Research Article, 'FGF signaling regulates #SalivaryGland branching morphogenesis by modulating cell adhesion' here:
A reviewer said, "This linkage between FGF signalling and #CellAdhesion provides a useful new dimension to understanding the mechanisms of #FGFsignalling".
Tong et al explore the conformational landscape of integrin αIIbβ3 from bent to extended states and the implication for adhesion stability.
"Integrin αIIbβ3 intermediates: From molecular dynamics to adhesion assembly"
https://doi.org/10.1016/j.bpj.2022.12.032
#Integrins #CellAdhesion
Getting more comfortable here and so it’s time for an #introduction ?
I never planned on doing a PhD and certainly not on staying afterwards. But somehow I got hooked on #microscopy and #celladhesion and especially #integrins , more recently also #TGF s. So I stopped my high school teacher career and here I am… And if research also doesn’t work out I might pursue a career in integrin-themed cakes
@soragnilab @MingqingCai @biorxivpreprint the problem with author-selected keywords is they are not helpful unless selected from a controlled vocabulary (e.g. #integrin will not show up in a search for #celladhesion) and then you have to decide/agree on and maintain the taxonomy (which is a nightmare). it's feasible for things like Human Phenotype Ontology, but that's the exception rather than the rule. search normally solves things but here that just means we're back to the original issue
#introduction:
We are a new cell systems biology team at the #UniversityOfManchester #UoM.
We study #CellAdhesion #networks in health and disease, especially #cancer.
Fascinated by how adhesion proteins help #cells function in so many ways!
#proteomics #integrins #adhesion #cytoskeleton #nucleus #bioinformatics #omics #ExtracellularMatrix #ECM #NetworkBiology #DataViz
#introduction:
I am a Lecturer and #NewPI at the #UniversityOfManchester #UoM
I am interested in how cellular interactions with the tumour microenvironment control fundamental aspects of cancer cell behaviour, including regulation of gene expression.
In @thebyronlab, we combine #proteomics, #sequencing, #bioinformatics, functional #CellBiology, super-resolution #imaging and #cancer models, to discover new properties of cancer #CellAdhesion #networks.
#introduction
Hello, this is Jose M de Pereda and I run a research group at the Center for Cancer Research in #Salamanca (Spain) (#CSIC #USAL).
We study the structural and mechanistic basis of #integrin based #CellAdhesion complexes (mostly #Hemidesmosomes) and of #Rap1 signaling. Knowing in detail how these molecular systems work is essential to understand how they are altered in diseases.
We do multidisciplinary research: #StructuralBiology #Biochemistry, #Biophysics and a bit of #CellBiology
Added @mechanobio to this bot series. This one was more tricky, as it selects abstracts mentioning molecules/structures (#cytoskeleton, #celladhesion) and some mechanics/morphogenesis. There's still room for improvement, don't hesitate to comment! @bortzmeyer @DavidBrueckner
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