Reverse Aging? This Scientist Has The Answer!
Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
Adaptation to Stress: Enhanced Tolerance to Cd2+ and Radiomimetics in Arabidopsis from the Chornobyl Zone - #Arabidopsisthaliana #DNAdamage #heavymetals #radiomimetics #genomicstability #planttolerance #Chornobyl #Cd #ChornobylZone - https://link.springer.com/article/10.3103/S0095452725050032
Reverse Aging? This Scientist Has The Answer!
Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
Folate Deficiency: DNA Damage Risk - Rhonda Patrick on DOAC
What if we could stop DNA repair errors before they happen — by moving the damage out of danger? #DNAdamage #CancerResearch #GenomeStability
https://geekoo.news/how-protein-droplets-shield-dna-from-catastrophic-errors/
Interesting new paper out in Cell today
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance #science #DNAdamage #cancer #research
[PDF] National Association of Marine Laboratories
Position Paper
Scientific opposition to Japan’s planned release of over 1.3 million tons of radioactively contaminated water from the #FukushimaDaiIchi #NuclearPowerPlant
disaster into the #PacificOcean.
December 2022
“The National Association of Marine Laboratories (#NAML), an organization of more than
100 member laboratories, opposes Japan’s plans to begin releasing over 1.3 million tons of radioactively contaminated water from the Fukushima-Daiichi Nuclear Power Plant into the Pacific Ocean commencing in 2023. This opposition is based on the fact that there is a lack of adequate and accurate scientific data supporting Japan’s assertion of safety.
"Furthermore, there is an abundance of data demonstrating serious concerns about releasing radioactively contaminated water.
“The Pacific Ocean is the largest continuous body of water on our planet, containing the greatest biomass of organisms of ecological, economic, and cultural value, including 70 percent of the world’s #fisheries. The health of all the world’s #OceanEcosystems is in documented decline due
to a variety of stressors, including climate change, over-exploitation of resources, and pollution.
"The proposed release of this #contaminated water is a #transboundary and #transgenerational issue of concern for the health of marine ecosystems and those whose lives and livelihoods depend on them. We are concerned about the absence of critical data on the radionuclide content of each tank, the Advanced Liquid Processing System, which is used to remove radionuclides, and the assumption that upon the release of the contaminated wastewater,
‘dilution is the solution to pollution.’
“The underlying rationale of #dilution ignores the reality of biological processes of #OrganicBinding,
#bioaccumulation, and #bioconcentration, as well as accumulation in local seafloor sediments. Many of the radionuclides contained in the accumulated waste cooling water have half-lives ranging from decades to centuries, and their deleterious effects range from #DNADamage and
#cellular stress to elevated #cancer risks in people who eat affected marine organisms, such as clams, oysters, crabs, lobster, shrimp, and fish.
"Additionally, the effectiveness of the Advanced Liquid Processing System in almost completely removing the over 60 different #radionuclides present in the affected wastewater—some of which have an affinity to target specific tissues, glands, organs, and metabolic pathways in #LivingOrganisms, including people—remains a
serious concern due to the absence of critical data.
"The supporting data provided by the Tokyo Electric Power Company and the #JapaneseGovernment are insufficient and, in some cases, incorrect, with flaws in sampling protocols, statistical design, sample analyses, and assumptions, which in turn lead to flaws in the
conclusion of safety and prevent a more thorough evaluation of better alternative approaches to disposal. A full range of approaches to addressing the problem of safely containing, storing, and disposing of the radioactive waste have not been adequately explored, and alternatives to ocean dumping should be examined in greater detail and with extensive scientific rigor.
“NAML calls on the Government of #Japan and International Atomic Energy Agency (#IAEA) scientists to more fully and adequately consider the options recommended by the #PacificIslandsForum’s Expert Panel. We believe public policy decisions, regulations, and actions must keep pace with and make use of relevant advancements in our scientific understanding of the #environment and human health. In this case, we believe policy makers have not fully availed themselves of the available science and should do so before making any final decisions on releasing this contaminated water into the Pacific. NAML members are unified in our concern about use of the oceans as a dumping ground for radioactively contaminated water and other #pollutants because such actions can negatively affect the long-term health and sustainability of
our planet.
“We urge the Government of Japan to stop pursuing their planned and precedent-setting release of the radioactively contaminated water into the Pacific Ocean and to work with the broader scientific community to pursue other approaches [like #ClosedLoop systems or binding radionuclides in concerete] that protect #OceanLife; human health; and
those communities who depend on ecologically, economically, and culturally valuable marine
resources. “
Adopted by the NAML Board of Directors, December 12, 2022
#WaterIsLife #OceansAreLife
#IAEAHides #TEPCOLies
#FukushimaIsntOver #NoDumping #NuclearPowerPlants #RadioactiveWater #RethinkNotRestart #PacificOcean #DataFalsification #ALPSSystem
Today Tim gave a quite vibrant presentation of the #biopixR package at our faculty at the #BTUCS. It was great to hear that some colleagues find it useful and want to use it for their research.
How does the Wnt pathway promote resistance to #DNAdamage induced by #IonizingRadiation? @BenForWard3 &co show that #WntSignaling modulates DNA damage response via EGFR in #Drosophila, protecting cells from #apoptosis induced by DNA ds breaks #PLOSBiology https://plos.io/4dduEiq
#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability
#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability
Why does DNA #mutation accumulation rate vary between our tissues? @N_t_n__l @molly_przew &co interpret “clock-like” mutation accumulation rate in humans, showing that it depends on underlying processes of #DNAdamage, repair & replication #PLOSBiology https://plos.io/3VwDTmH
When you have “ATM” in your name your destiny is to either work for a bank or become a researcher specialising in #DNAdamage #science #CellCycle
#Bacteria have a #DNAdamage response to aberrant #DNAmethylation, but how do they sense this damage? @Aditya_Kamat96 @Tung_BK_Le @dnarepairlab &co describe a TF that regulates a methylation-specific DNA damage response in #Caulobacter #PLOSBiology https://plos.io/3v7pdkD
McDonald’s pickles contain 10 ingredients?!? - YouTube
https://www.youtube.com/watch?v=KMTbFAz3deA
🥒 🥒 🥒 🥒 🥒 🥒 🥒
#health #pubMed #mcDonalds #pickle #10ingredients #dnaDamage #cancer #leakyGut #decreasedMicrobialDiversity #Alzheimers
😬
#Fukushima #Nuclear Power Plant starts 3rd round of #wastewater release, potentially impacting #seafood quality in U.S.
By Belle Lewis - November 14, 2023
"The #FukushimaDachii nuclear plant started its third release of nuclear wastewater on Nov. 2 as scientists warn that seafood products from the #PacificOcean could be #contaminated
"Although the International Atomic Energy Agency approved the 30-year water release plan, scientists and civilians in nations bordering the Pacific Ocean have questioned the safety of the plan, especially as it relates to seafood.
"In a press release approving of the plan, the IAEA stated, 'the discharges of the treated water would have a negligible radiological impact to people and the environment.'
"#PaulDorfman, member of the Irish Government Environmental Protection Agency Radiation Protection Advisory Committee and chair of Nuclear Consulting Group, explained that some scientists have questioned IAEA’s approval of the water release.
"'I and others are concerned by IAEA’s attitude,' Dorfman said. 'Normally even low levels of radioactive pollution will find its way into local seafood, one way or another.'
"In 2020, #Japan exported 332,926 kilograms of frozen scallops to the U.S. Japan exports many fish products to the U.S.
"Samantha Valeriano, a psychology student from Hawaii, said she eats seafood about once a week. She does not often think about where her food comes from but wants to be more cautious following the nuclear water release.
"'I think I would be a little more cautious of what I ate, checking labels a little bit more,' Valeriano said. 'I would be conscious of what I ate and where it came from.'
"As the People’s Republic of #China has imposed bans of Japanese fish exports, the #USA has supported the Japanese market by increasing fish purchases.
"In a press release, the #UnitedStates Embassy and Consulate in Japan explained that military bases in Japan will carry Japanese seafood as a way to buoy up seafood markets and undermine the PRC’s ban.
"'United States elected representatives and senior government officials have stood in solidarity with Japan during this baseless ban,' the statement said. 'Another step to help provide additional sales to counter the ban was to start selling Japanese seafood at the U.S. military facilities in Japan, both through the commissaries and mess halls.'
"According to the statement, government officials like former speaker #KevinMcCarthy ate seafood from Japan as a testament to Japan’s safety standards.
However, other U.S. agencies, like the National Association of #MarineLaboratories question whether accurate research was conducted by the IAEA and Japanese Government to determine safety of seafood products.
"They explain that the lack of data on potential health impacts is a cause for serious concern.
"'Many of the #radionuclides contained in the #accumulated waste cooling water have half-lives ranging from #decades to #centuries, and their deleterious effects range from #DNADamage and #cellular stress to elevated #cancer risks in people who eat affected marine organisms, such as #clams, #oysters, #crabs, #lobster, #shrimp and fish,' the statement reads. [Not to mention all the critters that feed off them! Bioaccumulation works up the food chain!]
"Eve Nagareda, medical laboratory science major from Hawaii, shared she wants to avoid seafood from dumping grounds even if levels are considered safe.
"'I think I would try to go as far as possible from it,' Nagareda said.
"Kylee Wasano, pre-communications disorders student from Oahu, agreed. She explained she feels that she might already be consuming contaminated seafood.
"'I feel like I already am eating that, and I just don’t know,' Wasano said. 'Anything that could expose you to (radiation) you should be considerate about.'
"As organizations weigh safety concerns, scientists turn to the water release process to determine potential effects."
#WaterIsLife #NoDumping #Hormesis #TEPCOLies #Corruption #Bioaccumulation #RethinkNotRestart #NoNukes #NoNewNukes
Planetary electromagnetic pollution: it is time to assess its impact
by Priyanka Bandara and David O Carpenter
Published December, 2018
"As the #PlanetaryHealthAlliance moves forward after a productive second annual meeting, a discussion on the rapid global proliferation of artificial #electromagnetic fields would now be apt. The most notable is the blanket of radiofrequency electromagnetic radiation, largely microwave radiation generated for wireless communication and surveillance technologies, as mounting scientific evidence suggests that prolonged exposure to radiofrequency electromagnetic radiation has serious biological and health effects. However, public exposure regulations in most countries continue to be based on the guidelines of the International Commission on Non-Ionizing Radiation Protection and Institute of Electrical and Electronics Engineers, which were established in the 1990s on the belief that only acute thermal effects are hazardous.
"Prevention of tissue heating by radiofrequency electromagnetic radiation is now proven to be ineffective in preventing biochemical and physiological interference. For example, acute non-thermal exposure has been shown to alter human brain metabolism by NIH scientists, electrical activity in the #brain, and systemic immune responses.
Chronic exposure has been associated with increased oxidative stress and #DNADamage, and cancer risk.
"Laboratory studies, including large rodent studies by the US National Toxicology Program and Ramazzini Institute of Italy, confirm these biological and health effects in vivo. As we address the threats to human health from the changing environmental conditions due to human activity, the increasing exposure to artificial electromagnetic radiation needs to be included in this discussion.
"Due to the exponential increase in the use of wireless personal communication devices (eg, mobile or cordless phones and WiFi or Bluetooth-enabled devices) and the infrastructure facilitating them, levels of exposure to radiofrequency electromagnetic radiation around the 1 GHz frequency band, which is mostly used for modern wireless communications, have increased from extremely low natural levels by about 1018 times. Radiofrequency electromagnetic radiation is also used for #radar, security scanners, #SmartMeters, and medical equipment (#MRI, diathermy, and #radiofrequency ablation). It is plausibly the most rapidly increasing #anthropogenic #environmental exposure since the mid-20th century, and levels will surge considerably again, as technologies like the Internet of Things and 5G add millions more radiofrequency transmitters around us.
"Unprecedented human exposure to radiofrequency electromagnetic radiation from conception until death has been occurring in the past two decades. Evidence of its effects on the #CNS, including altered #neurodevelopment and increased risk of some #neurodegenerative diseases, is a major concern considering the steady increase in their incidence. Evidence exists for an association between neurodevelopmental or behavioural disorders in children and exposure to wireless devices, and experimental evidence, such as the Yale finding, shows that prenatal exposure could cause structural and functional changes in the brain associated with #ADHD-like behaviour. These findings deserve urgent attention.
"At the Oceania Radiofrequency Scientific Advisory Association, an independent scientific organisation, volunteering scientists have constructed the world's largest categorised online database of peer-reviewed studies on radiofrequency electromagnetic radiation and other man-made electromagnetic fields of lower frequencies. A recent evaluation of 2266 studies (including in-vitro and in-vivo studies in human, animal, and plant experimental systems and population studies) found that most studies (n=1546, 68·2%) have demonstrated significant biological or health effects associated with exposure to anthropogenic electromagnetic fields. We have published our preliminary data on radiofrequency electromagnetic radiation, which shows that 89% (216 of 242) of experimental studies that investigated oxidative stress endpoints showed significant effects.
This weight of scientific evidence refutes the prominent claim that the deployment of wireless technologies poses no health risks at the currently permitted non-thermal radiofrequency exposure levels. Instead, the evidence supports the International EMF Scientist Appeal by 244 scientists from 41 countries who have published on the subject in peer-reviewed literature and collectively petitioned the WHO and the UN for immediate measures to reduce public exposure to artificial electromagnetic fields and radiation.
"Evidence also exists of the effects of radiofrequency electromagnetic radiation on #flora and #fauna. For example, the reported global reduction in #bees and other insects is plausibly linked to the increased radiofrequency electromagnetic radiation in the environment. #Honeybees are among the species that use magnetoreception, which is sensitive to anthropogenic electromagnetic fields, for navigation.
"Man-made electromagnetic fields range from extremely low frequency (associated with electricity supplies and #electrical appliances) to low, medium, high, and extremely high frequency (mostly associated with wireless communication). The potential effects of these anthropogenic electromagnetic fields on natural electromagnetic fields, such as the Schumann Resonance that controls the weather and climate, have not been properly studied. Similarly, we do not adequately understand the effects of anthropogenic radiofrequency electromagnetic radiation on other natural and man-made atmospheric components or the ionosphere. It has been widely claimed that radiofrequency electromagnetic radiation, being non-ionising radiation, does not possess enough photon energy to cause DNA damage. This has now been proven wrong experimentally.
"#RadiofrequencyElectromagneticRadiation causes DNA damage apparently through oxidative stress, similar to near-UV radiation, which was also long thought to be harmless.
"At a time when environmental health scientists tackle serious global issues such as #ClimateChange and chemical #toxicants in public health, there is an urgent need to address so-called #electrosmog. A genuine evidence-based approach to the risk assessment and regulation of anthropogenic electromagnetic fields will help the health of us all, as well as that of our planetary home. Some government health authorities have recently taken steps to reduce public exposure to radiofrequency electromagnetic radiation by regulating use of wireless devices by children and recommending preferential use of wired communication devices in general, but this ought to be a coordinated international effort.
We declare no competing interests. We thank Alasdair Philips for assistance with the figure and Victor Leach and Steve Weller for assistance with the ORSAA Database, which has enabled our overview of the scientific evidence in this area of research."
https://www.thelancet.com/journals/lanplh/article/PIIS2542-5196(18)30221-3/fulltext
"We summarize the toxic effects of #microplastics in cells, organoids, and animals. These effects consist of oxidative stress, #DNADamage, organ dysfunction, metabolic disorder, immune response, #neurotoxicity, as well as #reproductive and developmental toxicity. In addition, the epidemiological evidence suggests that a variety of #ChronicDiseases may be related to microplastics exposure."
SARS-CoV-2 infection induces DNA damage through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
NATURE CELL BIOLOGY • MAR 9, 2023
Addendum 2
Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation
https://www.biorxiv.org/content/10.1101/2023.09.07.556677v1?rss=1
* tardigrades survive doses of ionizing radiation 1000x human lethal dose
* specific, robust response to ionizing radiation
* irradiation induces rapid dramatic upregulation of DNA repair genes
#nematodes #cryptobiosis #tardigrades #permafrost #DNArepair #MolecularBiology #MolecularGenetics #DNAdamage
