#TP53 ist ein Gen, welches #Krebs bekämpft: es eliminiert kranke Zellen, bevor diese Krebs entwickeln. Wir Menschen haben wie fast alle Säugetiere eine Kopie dieses #P53 Gens, welches Tumore verhindert und DNA repariert. Afrikanische Elefanten haben 20 von diesen Tumorkillern. Folglich sind sie bestens vor Krebs geschützt https://pmc.ncbi.nlm.nih.gov/articles/PMC5061548/

New Publication Alert!
"The Effective Stress Response Role of p53 in Inducing Ferroptotic Cell Death"

Link:
https://lnkd.in/gPA6qVdC

#p53 #ferroptosis #stress #celldeath

Anh Chàng May Mắn P53 – nửa Đêm

Anh Chàng May Mắn P53 - nửa Đêm Nửa Đêm Your browser does not support HTML video. Anh Chàng May Mắn P53 - nửa Đêm #Anh #Chàng #Mắn #P53 #nửa #Đêm

https://simsothantai.com/2025/05/27/anh-chang-may-man-p53-nua-dem/

Elephants evolved to beat cancer, and how we could too

https://newatlas.com/biology/elephants-beat-evolution-cancer-p53-gene-petos-paradox/

#HackerNews #Elephants #Cancer #Evolution #P53 #Gene #Petos #Paradox

The protein #p53, known as the "guardian of the genome," plays a crucial role in preventing #cancer. When it malfunctions, tumors can form. Scientists are developing drugs to restore or mimic p53's function in cancer cells. A #biology researcher explains:
https://theconversation.com/p53-is-both-your-genomes-guardian-and-weakness-against-cancer-scientists-are-trying-to-repair-or-replace-it-when-it-goes-awry-248674 #science

Vous avez vu passer ça ?

https://xcancel.com/elonmusk/status/1890612949368058118#m

Il utilise le terme !

C'est exactement ce que sont tous les tarés autour de Trump: des virus cancérigènes, qui font sauter tous les garde-fous jusqu'à la réalité elle-même pour proliférer

#trump #musk #virus #maga #mega #usa #postverite #complotisme #bullshit #manipulation #psychologie #sociologie #croyances #espritcritique #intelligence #factchecking #p53 #cancer #racisme #antifa #antifascisme #harcelement #perversion #etatsunis #fascisme

my qubes laptop has about as many vms defined as my kubernetes cluster has pods. my thinkpad has as much or more memory than all of my servers

#qubesOS #qubes #kubernetes #k8s #thinkpad #p53

Company that plans to bring back the mammoth takes a key step
https://arstechnica.com/science/2024/03/de-extinction-company-manages-to-generate-first-elephant-stem-cells/ #rewilding #deextinction #mammoth #Colossal #mastodon?🦣 #manuscript #elephant #genome #p53

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

[thread] CRISPR
CRISPR gene editing: https://en.wikipedia.org/wiki/CRISPR_gene_editing

Eliminating extra chromosomes in cancer cells prevents tumor growth
https://www.sciencedaily.com/releases/2023/07/230706152349.htm

* Cancer cells w. extra chromosomes depend on those chromosomes for tumor growth
* eliminating them prevents those cells f. forming tumors
* suggests selectively targeting extra chromosomes may offer a new route for treating cancer

Comment: basic research, not treatment!

#cancer #CancerCells #TumorGrowth #aneuploidy #CRISPR #p53 #TP53 #MDM4

Tatsuki Tsuruoka, Kazuyasu Sakaguchi, Toshiaki Imagawa and colleagues share their reporter system for visualising transcriptional activity of p53 at the single cell level.

https://journals.biologists.com/jcs/article/136/12/jcs260918/316739/Development-of-a-fluorescence-reporter-system-to

#cellbiology #p53

TIL (from #ChatGPT 's imagination) that one of our people at @GordianBio discovered the importance of #p53 and is moonlighting as a #Caltech professor 🤣

In single pancreatic cells responding to oxidative stress, JNK dynamics regulate an early trigger of cell death, #p53 controls late maintenance of cell cycle arrest &p38 controls a switch between JNK- and p53-dependent cell fate➡️ http://bit.ly/3UPf6YM E Batchelor (UMN Medical School) #QBio #cellfate #SystemsBiology

Hi #ScienceMastodon - my lab's most recent findings just hit preprint here: https://www.sciencedirect.com/science/article/pii/S0022202X22018887?via%3Dihub

We discovered a #mousemodel for examining #cSCC where #mice with epidermal deficiency of #KDM6A and #P53 show 100% penetrant, spontaneous cSCC development within a year!

#dermatology and #skincancer have very few models to study cSCC in mice and our lab found one!

#cancer #epigenetics #academicchatter #derm #tumorsuppressors #tumor #scicomm

[#Actu] « Cancer : les éléphants préservés grâce à un gène zombie » https://www.futura-sciences.com/sante/actualites/cancer-cancer-elephants-preserves-grace-gene-zombie-70422/#xtor=RSS-8 #gènenonfonctionnel #éléphantdafrique #réparationdeladn #adnpoubelle #non-codant #gènezombie #éléphant #mutation #cancer #génome #taille #gêne #lif6 #p53