https://www.fogolf.com/1143345/p53-acquires-golf-club-manufacturing-and-chroming-assets-from-arizona-based-the-iron-factory-inc/ P53 Acquires Golf Club Manufacturing and Chroming Assets from Arizona-based The Iron Factory, Inc. #AssetAcquisition #ChristopherGriffin #chroming #Golf #GolfIrons #GolfNews #IronFactory #JimKronus #P53

I hope everyone's watching #CancerDetectives on Channel 4!
My team has sweated over various aspects of this. It's a big passion project, my colleague's second baby, and hopefully will help more people understand what it means to do #CancerResearch today, and indeed what it means to have cancer now, compared to some decades ago.

#channel4 #cancer #cancerVaccines #BrainTumours #LiquidBiopsy #cancerOfUnknownPrimary #LungCancer #P53 #liFraumeni #5GTrial #MILITrial #DETECTION2Trial #CancerResearchUK

@aral @Rawan_kh22 @alaa123 @salemgaza @Hackingsocial @RichardMonvoisin @defakator

For me there is a striking resemblance between humans trying to do social manipulation and p53 protein theme.

Like carcinogenic viruses, perversion, indoctrination and other problems, people who do power abuses need to fight against safeguards

P53 is often one of the first safeguard with harmful mutation in cancers..

#hackingsocial #biology #technofascism #technofeudalism #checksandbalances #p53 #carcinogenesis

#TP53 ist ein Gen, welches #Krebs bekämpft: es eliminiert kranke Zellen, bevor diese Krebs entwickeln. Wir Menschen haben wie fast alle Säugetiere eine Kopie dieses #P53 Gens, welches Tumore verhindert und DNA repariert. Afrikanische Elefanten haben 20 von diesen Tumorkillern. Folglich sind sie bestens vor Krebs geschützt https://pmc.ncbi.nlm.nih.gov/articles/PMC5061548/

New Publication Alert!
"The Effective Stress Response Role of p53 in Inducing Ferroptotic Cell Death"

Link:
https://lnkd.in/gPA6qVdC

#p53 #ferroptosis #stress #celldeath

Elephants evolved to beat cancer, and how we could too

https://newatlas.com/biology/elephants-beat-evolution-cancer-p53-gene-petos-paradox/

#HackerNews #Elephants #Cancer #Evolution #P53 #Gene #Petos #Paradox

The protein #p53, known as the "guardian of the genome," plays a crucial role in preventing #cancer. When it malfunctions, tumors can form. Scientists are developing drugs to restore or mimic p53's function in cancer cells. A #biology researcher explains:
https://theconversation.com/p53-is-both-your-genomes-guardian-and-weakness-against-cancer-scientists-are-trying-to-repair-or-replace-it-when-it-goes-awry-248674 #science

Vous avez vu passer ça ?

https://xcancel.com/elonmusk/status/1890612949368058118#m

Il utilise le terme !

C'est exactement ce que sont tous les tarés autour de Trump: des virus cancérigènes, qui font sauter tous les garde-fous jusqu'à la réalité elle-même pour proliférer

#trump #musk #virus #maga #mega #usa #postverite #complotisme #bullshit #manipulation #psychologie #sociologie #croyances #espritcritique #intelligence #factchecking #p53 #cancer #racisme #antifa #antifascisme #harcelement #perversion #etatsunis #fascisme

my qubes laptop has about as many vms defined as my kubernetes cluster has pods. my thinkpad has as much or more memory than all of my servers

#qubesOS #qubes #kubernetes #k8s #thinkpad #p53

Company that plans to bring back the mammoth takes a key step
https://arstechnica.com/science/2024/03/de-extinction-company-manages-to-generate-first-elephant-stem-cells/ #rewilding #deextinction #mammoth #Colossal #mastodon?🦣 #manuscript #elephant #genome #p53

Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

[thread] CRISPR
CRISPR gene editing: https://en.wikipedia.org/wiki/CRISPR_gene_editing

Eliminating extra chromosomes in cancer cells prevents tumor growth
https://www.sciencedaily.com/releases/2023/07/230706152349.htm

* Cancer cells w. extra chromosomes depend on those chromosomes for tumor growth
* eliminating them prevents those cells f. forming tumors
* suggests selectively targeting extra chromosomes may offer a new route for treating cancer

Comment: basic research, not treatment!

#cancer #CancerCells #TumorGrowth #aneuploidy #CRISPR #p53 #TP53 #MDM4

Tatsuki Tsuruoka, Kazuyasu Sakaguchi, Toshiaki Imagawa and colleagues share their reporter system for visualising transcriptional activity of p53 at the single cell level.

https://journals.biologists.com/jcs/article/136/12/jcs260918/316739/Development-of-a-fluorescence-reporter-system-to

#cellbiology #p53

TIL (from #ChatGPT 's imagination) that one of our people at @GordianBio discovered the importance of #p53 and is moonlighting as a #Caltech professor 🤣

In single pancreatic cells responding to oxidative stress, JNK dynamics regulate an early trigger of cell death, #p53 controls late maintenance of cell cycle arrest &p38 controls a switch between JNK- and p53-dependent cell fate➡️ http://bit.ly/3UPf6YM E Batchelor (UMN Medical School) #QBio #cellfate #SystemsBiology

Hi #ScienceMastodon - my lab's most recent findings just hit preprint here: https://www.sciencedirect.com/science/article/pii/S0022202X22018887?via%3Dihub

We discovered a #mousemodel for examining #cSCC where #mice with epidermal deficiency of #KDM6A and #P53 show 100% penetrant, spontaneous cSCC development within a year!

#dermatology and #skincancer have very few models to study cSCC in mice and our lab found one!

#cancer #epigenetics #academicchatter #derm #tumorsuppressors #tumor #scicomm

[#Actu] « Cancer : les éléphants préservés grâce à un gène zombie » https://www.futura-sciences.com/sante/actualites/cancer-cancer-elephants-preserves-grace-gene-zombie-70422/#xtor=RSS-8 #gènenonfonctionnel #éléphantdafrique #réparationdeladn #adnpoubelle #non-codant #gènezombie #éléphant #mutation #cancer #génome #taille #gêne #lif6 #p53