Oleic acid from olive oil reduces infection-related bone loss with age
New re…
#dining #cooking #diet #food #MediterraneanOliveOil #OliveOil ##inflammation #aging #Antibiotic #Bacterial #Bone #cardiovasculardisease #Diabetes #ImmuneResponse #Mediterranean #MediterraneanDiet #Microbiome #MouseModel #Olive #Osteoclast #osteoporosis #Periodontitis #Research #saturatedfats #stress #teeth
https://www.diningandcooking.com/2154139/oleic-acid-from-olive-oil-reduces-infection-related-bone-loss-with-age/
"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."
https://doi.org/10.1177/0960327119877460
#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology
Our new #preprint on #ThreePhoton in vivo #imaging of #neurons and #glia 🔬 in the medial prefrontal cortex (#mPFC) 🧠 with sub-cellular resolution 🔍 is out! Check it out on #biorxiv:
🌍 https://www.biorxiv.org/content/10.1101/2024.08.28.610026v1
#Neuroscience #multiphoton #3p vs. #2p #twophoton #hippocampus #drosophila #MouseModel #DeepImaging #preprintalert #DZNE @dzne
DAMM, Detect Any #MouseModel 🐭, has just been released 👌 It’s a robustly validated mouse detector that excels in generalization, tracking mice in complex social and experimental settings with zero to minimal setup-specific training
🌍 http://web.eecs.umich.edu/gkaul/DAMM
🌍 GitHub: http://github.com/backprop64/DAMM
📒 Kaul et al. (2024) http://biorxiv.org/content/10.1101/2024.01.18.576153v1
#BehavioralScience #behavioralanalysis #neuroscience #machinelearning
this is: "not good"
Chinese scientists create COVID-19 strain that is 100% lethal to ‘humanized’ mice, report says
https://www.silive.com/news/2024/01/chinese-scientists-create-covid-19-strain-that-is-100-lethal-to-humanized-mice-report-says.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987100/
#Covid19 #Epidemiology #InfectiousDiseases #PublicHealth #MouseModel
Macrophages are essential immune cells that reside in all tissues. Some macrophages arise from monocytes in the blood, but during fetal development they also come from a unique pathway!
We still have a lot to learn, but here I'll describe how Zhao et al. (2023) used mouse models to uncover hints about which progenitor cells create tissue-macrophages.
https://doi.org/10.1016/j.celrep.2023.113364
#Macrophages #MouseModel #Immunology #Immunity #scRNAseq #FlowCytometry #Research #JournalArticle #JournalClub
1/9🧵
Really cool application of Infinity Flow to #MouseModel #Tcells, which allows readout/prediction of >200 surface epitopes on single cells via #FlowCytometry.
A novel orthotopic mouse model replicates human lung cancer cachexia. https://doi.org/10.1002/jcsm.13222 #CancerCachexia #LungCancer #MuscleWasting #MouseModel #OrthotopicMouseModel
New results in a mouse model "demonstrate the rapid and potent effects of [artificial light at night] on cerebrovascular networks, highlighting the importance of ALAN mitigation in the context of health and cerebrovascular disease."
https://www.cell.com/iscience/fulltext/S2589-0042(23)01073-8
#Neuroscience #Chronobiology #MouseModel #ModelOrganism #Cerebrovascular #ALAN
#scientists previously believed silent synapses were only present during early development; however, #mousemodel research found that about 30% of all synapses in the cortex are silent.
#scientists previously believed silent synapses were only present during early development; however, #mousemodel research found that about 30% of all synapses in the cortex are silent.
With new data analysis coming out showing 4 main subtypes of #longcovid, we're always here to help #mousemodel development to address these areas specifically.
Meet Dr Emily Warren, 1st author of new #OpenAccess paper from Dr Eric Morrow's lab at #BrownUniversity
They developed the 1st lab model of 17q12 deletion syndrome, a copy number variant disorder associated with #neurodevelopmental disorders and #RenalCysts and #diabetes syndrome. The #MouseModel recapitulated many features of the human disorder & will be used to guide #clinical & #mechanistic studies
Interview & research article:
👩🏻🔬https://journals.biologists.com/dmm/article/15/12/dmm050017/285934/
📰https://journals.biologists.com/dmm/article/15/12/dmm049752/285935/
#introduction I am Peggy Wei, an #NewPI (3 years old) at #DKFZ . I am also a mother with two children, and a cooking lover. We use #omics and #mousemodel to understand genome integrity and somatic mosaicism in the developing #brain. Other interests include but not limited to #neuropsychiatric disorders , #cancer origin, DNA #replication, #CNV, and #singlemolecule view of DNA damage. I transferred from the other server (@braingenome@scicomm.xyz) because I feel closer to genomics.
#introduction I am Peggy Wei, an #NewPI (3 years old) at #DKFZ . I am also a mother with two children, and a cooking lover. We use #omics and #mousemodel to understand genome integrity and somatic mosaicism in the developing #brain. Other interests include but not limited to #neuropsychiatric disorders , #cancer origin, DNA #replication, #CNV, and #singlemolecule view of DNA damage.
Hi #ScienceMastodon - my lab's most recent findings just hit preprint here: https://www.sciencedirect.com/science/article/pii/S0022202X22018887?via%3Dihub
We discovered a #mousemodel for examining #cSCC where #mice with epidermal deficiency of #KDM6A and #P53 show 100% penetrant, spontaneous cSCC development within a year!
#dermatology and #skincancer have very few models to study cSCC in mice and our lab found one!
#cancer #epigenetics #academicchatter #derm #tumorsuppressors #tumor #scicomm
